PRDX1 Active Protein

Name: PRDX1 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203281
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203281

PRDX1 is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. This protein is also known to be important to protect red blood cells against reactive oxygen species and in tumor prevention.… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PRDX1, Active Protein

Full Product Name

PRDX1, 1-199aa, Human, His tag, E Coli (Bioactivity Validated)

Product Gene Name

PRDX1 active protein

Product Synonym Names

Peroxiredoxin 1; MSP23; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2; Thioredoxin peroxidase 2; Peroxiredoxin 1; PRDX1; Peroxiredoxin 1 Hbp23; Heme binding 23 kDa protein; Paga; Prdx 1; Macrophage 23 Kd stress protein; NKEF A; NkefA; OSF3; Macrophage 23kDa stress protein; PrxI; Tdpx 2; TDX2; Macrophase stress protein 22kDa; TPxA Macrophase stress protein 23 kd; Natural killer cell enhancing factor A; Natural killer enhancing factor A; Osteoblast specific factor 3; Proliferation associated gene A; Proliferation associated protein PAG; Thioredoxin dependent peroxide reductase 2

Sequence

MGSSHHHHHH SSGLVPRGSH MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVQK SKEYFSKQK

Host

E Coli

Form/Format

Liquid in 20 mM Tris, pH 7.5, 20% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

24 kDa (219 aa), confirmed by MALDI-TOF.

OMIM

X67951 mRNA

3D Structure

ModBase 3D Structure for Q06830

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Antigen Species

Human

Tag Information

His-tag

Biological Activity

Specific activity is >2,000 pmol/min/ug. Enzymatic activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for minute.

Product Categories/Family for PRDX1 active protein

Redox Proteins

Applications Tested/Suitable for PRDX1 active protein

SDS-PAGE

Product References and Citations for PRDX1 active protein

Iraqui I., et al. (2008) Cancer Res. 68 (4):1055-63.; Parmigiani RB., et al. (2008) Proc Natl Acad Sci u S A. 105 (28):9633-8.; Kim JH., et al. (2008) Clin Cancer Res. 14 (8):2326-33.;

Other Notes

Small volumes of PRDX1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX1 purchase

MBS203281 is an active protein targeting PRDX1. Also known as PRDX1, 1-199aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX1. It may not necessarily be applicable to this product.

NCBI GI #

4505591

NCBI GeneID

5052

NCBI Accession #

NP_002565

UniProt Primary Accession #

Q06830

UniProt Secondary Accession #

P35703; Q2V576; Q5T154; Q5T155; B5BU26; D3DPZ8

UniProt Related Accession #

Q06830

GenBank Nucleotide #

NM_002574.3

NCBI Official Full Name

peroxiredoxin-1

NCBI Official Synonym Full Names

peroxiredoxin 1

NCBI Official Symbol

PRDX1

NCBI Official Synonym Symbols

PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A

UniProt Protein Name

Peroxiredoxin-1

UniProt Synonym Protein Names

Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2

Protein Family

Peroxiredoxin

UniProt Gene Name

PRDX1

UniProt Synonym Gene Names

PAGA; PAGB; TDPX2; NKEF-A; PAG

NCBI Protein Information

peroxiredoxin-1

NCBI Summary for PRDX1

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

UniProt Comments for PRDX1

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2 (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation ().

Research Articles on PRDX1

1. Prx1 might play an oncogenic role in tobacco-related oral squamous cell carcinoma and thus serve as a target for chemopreventive and therapeutic interventions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRDX1 active protein

Reference Product	PubMed Publications
PRDX5 active protein	>20 publications with PRDX1 and PRDX5
CAT active protein	>20 publications with PRDX1 and CAT
SOD1 active protein	>18 publications with PRDX1 and SOD1
TXN active protein	>11 publications with PRDX1 and TXN
SRXN1 active protein	>10 publications with PRDX1 and SRXN1

Pathways associated with PRDX1 active protein

Products by Pathway	Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Coregulation Of Androgen Receptor Activity Pathway antibodies	Coregulation Of Androgen Receptor Activity Pathway Diagram
Deregulated CDK5 Triggers Multiple Neurodegenerative Pathways In Alzheimer's Disease Models antibodies	Deregulated CDK5 Triggers Multiple Neurodegenerative Pathways In Alzheimer's Disease Models Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
NRF2 Pathway antibodies	NRF2 Pathway Diagram
Neurodegenerative Diseases Pathway antibodies	Neurodegenerative Diseases Pathway Diagram

Diseases associated with PRDX1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>30 publications with PRDX1 and Inflammation
Lung Diseases Antibodies	>25 publications with PRDX1 and Lung Diseases
Disease Models, Animal Antibodies	>25 publications with PRDX1 and Disease Models, Animal
Liver Diseases Antibodies	>20 publications with PRDX1 and Liver Diseases
Lung Neoplasms Antibodies	>17 publications with PRDX1 and Lung Neoplasms
Breast Neoplasms Antibodies	>15 publications with PRDX1 and Breast Neoplasms
Necrosis Antibodies	>14 publications with PRDX1 and Necrosis
Lung Injury Antibodies	>11 publications with PRDX1 and Lung Injury
Liver Neoplasms Antibodies	>10 publications with PRDX1 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>8 publications with PRDX1 and Carcinoma, Hepatocellular

Organs/Tissues associated with PRDX1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>53 publications with PRDX1 and Blood
Liver Antibodies	>37 publications with PRDX1 and Liver
Lung Antibodies	>35 publications with PRDX1 and Lung
Vascular Antibodies	>26 publications with PRDX1 and Vascular
Brain Antibodies	>26 publications with PRDX1 and Brain
Muscle Antibodies	>14 publications with PRDX1 and Muscle
Kidney Antibodies	>13 publications with PRDX1 and Kidney
Nerve Antibodies	>12 publications with PRDX1 and Nerve
Heart Antibodies	>11 publications with PRDX1 and Heart
Bone Antibodies	>9 publications with PRDX1 and Bone