Dicer 1, Ribonuclease Type III (DICER1) Antibody – Rabbit Polyclonal

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described.

Protein type: Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: axon; cytoplasm; cytosol; dendrite; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; growth cone; nucleus; RISC complex

Molecular Function: ATP binding; deoxyribonuclease I activity; DNA binding; double-stranded RNA binding; endoribonuclease activity; helicase activity; metal ion binding; protein binding; protein domain specific binding; ribonuclease III activity; siRNA binding

Biological Process: apoptotic DNA fragmentation; conversion of ds siRNA to ss siRNA; miRNA metabolic process; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; negative regulation of Schwann cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nerve development; neuron projection morphogenesis; peripheral nervous system myelin formation; positive regulation of myelination; positive regulation of Schwann cell differentiation; pre-microRNA processing; RNA interference, conversion of ds siRNA to ss siRNA; RNA interference, production of siRNA; RNA interference, targeting of mRNA for destruction; RNA phosphodiester bond hydrolysis, endonucleolytic; siRNA loading onto RISC involved in RNA interference

Disease: Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Pleuropulmonary Blastoma; Rhabdomyosarcoma, Embryonal, 2