FTH1 Recombinant Protein

Name: FTH1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203294
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203294

Ferritin, heavy polypeptide 1 (FTH1) is a ubiquitous protein which plays a major role in iron sequestration, detoxification and storage. FTH1 is found in all living species. FTH1 encodes the heavy subunit of ferritin, the major intracellular iron storage… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FTH1, Recombinant Protein

Full Product Name

FTH1, 1-183aa, Human, E Coli

Product Gene Name

FTH1 recombinant protein

Product Synonym Names

Ferritin heavy polypeptide 1; FTH; PLIF; FTHL6; PIG15; Ferritin heavy polypeptide 1; FTH1; Ferritin; heavy polypeptide 1 Apoferritin Cell proliferation inducing gene 15 protein; F HC; Ferritin H subunit; Ferritin heavy chain; FHC; FRIH; FTH 1; FTH1 protein; FTHL 6; Iron overload autosomal dominant; MGC104426; PIG 15; Placenta immunoregulatory factor; Proliferation inducing gene 15 protein; Proliferation inducing protein 15.

Sequence

MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA MECALHLEKN VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKAIKELG DHVTNLRKMG APESGLAEYL FDKHTLGDSD NES

Host

E Coli

Form/Format

Liquid in 20mM Tris pH 7.5, 1mM DTT, 10% glycerol

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

21kDa (183aa), confirmed by MALDI-TOF.

OMIM

X00318 mRNA

3D Structure

ModBase 3D Structure for P02794

Antigen Species

Human

Product Categories/Family for FTH1 recombinant protein

Serology

Applications Tested/Suitable for FTH1 recombinant protein

SDS-PAGE

Product References and Citations for FTH1 recombinant protein

Percy ME., et al. (1998).Analyst. 123 (1):41-50; Levens E., et al. (2005).Mol Hum Reprod. 11; (7):489-94;

Other Notes

Small volumes of FTH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FTH1 purchase

MBS203294 is a recombinant protein targeting FTH1. Also known as FTH1, 1-183aa, Human, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FTH1. It may not necessarily be applicable to this product.

NCBI GI #

56682959

NCBI GeneID

2495

NCBI Accession #

NP_002023

UniProt Primary Accession #

P02794

UniProt Secondary Accession #

Q3KRA8; Q3SWW1; B3KNR5

UniProt Related Accession #

P02794

GenBank Nucleotide #

NM_002032.2

NCBI Official Full Name

ferritin heavy chain

NCBI Official Synonym Full Names

ferritin heavy chain 1

NCBI Official Symbol

FTH1

NCBI Official Synonym Symbols

FHC; FTH; HFE5; PLIF; FTHL6; PIG15

UniProt Protein Name

Ferritin heavy chain

UniProt Synonym Protein Names

Cell proliferation-inducing gene 15 protein

Protein Family

Iron transporter

UniProt Gene Name

FTH1

UniProt Synonym Gene Names

FTH; FTHL6; Ferritin H subunit

NCBI Protein Information

ferritin heavy chain

NCBI Summary for FTH1

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

UniProt Comments for FTH1

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney ().

Research Articles on FTH1

1. The H-ferritin could bind up to 24 NCOA4(383-522) fragments forming highly stable and insoluble complexes. The binding was partially inhibited only by Fe(II) among the various divalent metal ions analyzed. The iron-dependent, highly-specific formation of the remarkably stable H-ferritin-NCOA4 complex shown in this work may be important for the characterization of the mechanism of ferritinophagy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FTH1 recombinant protein

Reference Product	PubMed Publications
FTL recombinant protein	>16 publications with FTH1 and FTL
TFRC recombinant protein	>7 publications with FTH1 and TFRC
MYC recombinant protein	>2 publications with FTH1 and MYC
MAX recombinant protein	>1 publications with FTH1 and MAX

Pathways associated with FTH1 recombinant protein

Products by Pathway	Pathway Diagram
Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies	Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
Clathrin Derived Vesicle Budding Pathway antibodies	Clathrin Derived Vesicle Budding Pathway Diagram
Ferroptosis Pathway antibodies	Ferroptosis Pathway Diagram
Ferroptosis Pathway antibodies	Ferroptosis Pathway Diagram
Golgi Associated Vesicle Biogenesis Pathway antibodies	Golgi Associated Vesicle Biogenesis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Iron Metabolism In Placenta Pathway antibodies	Iron Metabolism In Placenta Pathway Diagram
Iron Uptake And Transport Pathway antibodies	Iron Uptake And Transport Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram

Diseases associated with FTH1 recombinant protein

Disease Name	Pubmed Publications
Death Antibodies	>12 publications with FTH1 and Death
Inflammation Antibodies	>9 publications with FTH1 and Inflammation
Nervous System Diseases Antibodies	>9 publications with FTH1 and Nervous System Diseases
Liver Diseases Antibodies	>7 publications with FTH1 and Liver Diseases
Iron Overload Antibodies	>5 publications with FTH1 and Iron Overload
Necrosis Antibodies	>4 publications with FTH1 and Necrosis
Neurodegenerative Diseases Antibodies	>3 publications with FTH1 and Neurodegenerative Diseases
Lung Diseases Antibodies	>2 publications with FTH1 and Lung Diseases
Atherosclerosis Antibodies	>2 publications with FTH1 and Atherosclerosis
Carcinoma, Hepatocellular Antibodies	>2 publications with FTH1 and Carcinoma, Hepatocellular

Organs/Tissues associated with FTH1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>21 publications with FTH1 and Blood
Brain Antibodies	>14 publications with FTH1 and Brain
Liver Antibodies	>12 publications with FTH1 and Liver
Bone Antibodies	>9 publications with FTH1 and Bone
Nerve Antibodies	>8 publications with FTH1 and Nerve
Bone Marrow Antibodies	>7 publications with FTH1 and Bone Marrow
Muscle Antibodies	>6 publications with FTH1 and Muscle
Placenta Antibodies	>5 publications with FTH1 and Placenta
Skin Antibodies	>4 publications with FTH1 and Skin
Adipose Tissue Antibodies	>4 publications with FTH1 and Adipose Tissue