HOMER 1 Recombinant Protein

Name: HOMER 1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203314
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203314

Homer 1 (Homer protein homolog 1) belongs to Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Homer 1, Recombinant Protein

Full Product Name

Homer 1, 1- 354aa, Human, His tag, E Coli

Product Gene Name

Homer 1 recombinant protein

Product Synonym Names

Homer protein homolog 1; HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47; Homer protein homolog 1; Homer 1; Homer protein homolog 1 HOMER 1A; HOMER 1B; HOMER 1C; Homer; neuronal immediate early gene; 1; HOMER1; Ves 1

Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE QPIFSTRAHV FQIDPNTKKN WVPTSKHAVT VSYFYDSTRN VYRIISLDGS KAIINSTITP NMTFTKTSQK FGQWADSRAN TVYGLGFSSE HHLSKFAEKF QEFKEAARLA KEKSQEKMEL TSTPSQESAG GDLQSPLTPE SINGTDDERT PDVTQNSEPR AEPTQNALPF SHSSAISKHW EAELATLKGN NAKLTAALLE STANVKQWKQ QLAAYQEEAE RLHKRVTELE CVSSQANAVH THKTELNQTI QELEETLKLK EEEIERLKQE IDNARELQEQ RDSLTQKLQE VEIRNKDLEG QLSDLEQRLE KSQNEQEAFR NNLKTLLEIL DGKIFELTEL RDNLAKLLEC S

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl 20% glycerol, and 1 mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

1.0 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

44.5 kDa (391 aa), confirmed by MALDI-TOF.

OMIM

AF093262 mRNA

3D Structure

ModBase 3D Structure for Q86YM7

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for Homer 1 recombinant protein

Signal Transduction

Applications Tested/Suitable for Homer 1 recombinant protein

SDS-PAGE

Product References and Citations for Homer 1 recombinant protein

Szumlinski KK., et al. (2008) Biochem Pharmacol. 75 (1):112-133.; Roche KW., et al. (1999) J Biol Chem. 274 (36):25953-7.;

Other Notes

Small volumes of Homer 1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Homer 1 purchase

MBS203314 is a recombinant protein targeting Homer 1. Also known as Homer 1, 1- 354aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Homer 1. It may not necessarily be applicable to this product.

NCBI GI #

4759198

NCBI GeneID

9456

NCBI Accession #

NP_004263

UniProt Primary Accession #

Q86YM7

UniProt Secondary Accession #

O96003; Q86YM5; B2R688

UniProt Related Accession #

Q86YM7

GenBank Nucleotide #

NM_004272.4

NCBI Official Full Name

homer protein homolog 1 isoform 1

NCBI Official Synonym Full Names

homer scaffolding protein 1

NCBI Official Symbol

HOMER1

NCBI Official Synonym Symbols

HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C

UniProt Protein Name

Homer protein homolog 1

Protein Family

Homer protein

UniProt Gene Name

HOMER1

UniProt Synonym Gene Names

SYN47; Homer-1

NCBI Protein Information

homer protein homolog 1

NCBI Summary for Homer 1

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

UniProt Comments for Homer 1

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

Research Articles on Homer 1

1. Study shows that Homer1b/c is constitutively expressed in astrocytes, where it clusters with mGlu5 and endoplasmic reticulum tubules to form sub-plasmalemmal microdomains; propose that Homer1a may represent one of the cellular mechanisms by which inflammatory astrocytic reactions are beneficial for limiting brain injury

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Homer 1 recombinant protein

Reference Product	PubMed Publications
HOMER2 recombinant protein	>18 publications with Homer 1 and HOMER2
GRM5 recombinant protein	>13 publications with Homer 1 and GRM5
DLG4 recombinant protein	>11 publications with Homer 1 and DLG4
HOMER3 recombinant protein	>7 publications with Homer 1 and HOMER3
SHANK3 recombinant protein	>4 publications with Homer 1 and SHANK3
SHANK2 recombinant protein	>3 publications with Homer 1 and SHANK2
SHANK1 recombinant protein	>2 publications with Homer 1 and SHANK1
GRM1 recombinant protein	>1 publications with Homer 1 and GRM1

Pathways associated with Homer 1 recombinant protein

Products by Pathway	Pathway Diagram
BDNF-TrkB Signaling Pathway antibodies	BDNF-TrkB Signaling Pathway Diagram
Circadian Rythm Related Genes Pathway antibodies	Circadian Rythm Related Genes Pathway Diagram
FoxO Signaling Pathway antibodies	FoxO Signaling Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Interactions Of Neurexins And Neuroligins At Synapses Pathway antibodies	Interactions Of Neurexins And Neuroligins At Synapses Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Protein-protein Interactions At Synapses Pathway antibodies	Protein-protein Interactions At Synapses Pathway Diagram

Diseases associated with Homer 1 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>26 publications with Homer 1 and Nervous System Diseases
Brain Diseases Antibodies	>12 publications with Homer 1 and Brain Diseases
Disease Models, Animal Antibodies	>11 publications with Homer 1 and Disease Models, Animal
Learning Disorders Antibodies	>8 publications with Homer 1 and Learning Disorders
Pain Antibodies	>8 publications with Homer 1 and Pain
Cocaine-Related Disorders Antibodies	>8 publications with Homer 1 and Cocaine-Related Disorders
Depressive Disorder Antibodies	>7 publications with Homer 1 and Depressive Disorder
Memory Disorders Antibodies	>6 publications with Homer 1 and Memory Disorders
Inflammation Antibodies	>5 publications with Homer 1 and Inflammation
Sleep Wake Disorders Antibodies	>5 publications with Homer 1 and Sleep Wake Disorders

Organs/Tissues associated with Homer 1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>89 publications with Homer 1 and Brain
Nerve Antibodies	>27 publications with Homer 1 and Nerve
Muscle Antibodies	>15 publications with Homer 1 and Muscle
Blood Antibodies	>8 publications with Homer 1 and Blood
Kidney Antibodies	>3 publications with Homer 1 and Kidney
Adrenal Gland Antibodies	>2 publications with Homer 1 and Adrenal Gland
Vascular Antibodies	>2 publications with Homer 1 and Vascular
Eye Antibodies	>2 publications with Homer 1 and Eye
Heart Antibodies	>2 publications with Homer 1 and Heart
Testis Antibodies	>1 publications with Homer 1 and Testis