CHGA Recombinant Protein – Cat# MBS203324

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Chromogranin-A (CHGA) Recombinant Protein

Name: CHGA Recombinant Protein; Chromogranin-A; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203324
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203324

Chromogranin A is a member of the chromogranin/secretogranin (granins) family of neuroendocrine secretory proteins. Chromogranin A (CgA) represents the major soluble protein co-stored and co-released with catecholamines, within chromaffin cells secretory… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Chromogranin-A (CHGA), Recombinant Protein

Full Product Name

Chromogranin-A, 19-457aa, Human, His tag, E Coli

Product Gene Name

CHGA recombinant protein

Product Synonym Names

CgA; CHGA; Pituitary secretory protein I (SP1); Chromogranin-A; beta Granin; CHG A; Chromogranin A precursor; SP I; Chromogranin A parathyroid secretory protein 1; ChromograninA; Pancreastatin; Parastatin; Parathyroid secretory protein 1; SP1; SPI; Vasostatin; Pituitary secretory protein I

Sequence

MGSSHHHHHH SSGLVPRGSH MLPVNSPMNK GDTEVMKCIV EVISDTLSKP SPMPVSQECF ETLRGDERIL SILRHQNLLK ELQDLALQGA KERAHQQKKH SGFEDELSEV LENQSSQAEL KEAVEEPSSK DVMEKREDSK EAEKSGEATD GARPQALPEP MQESKAEGNN QAPGEEEEEE EEATNTHPPA SLPSQKYPGP QAEGDSEGLS QGLVDREKGL SAEPGWQAKR EEEEEEEEEA EAGEEAVPEE EGPTVVLNPH PSLGYKEIRK GESRSEALAV DGAGKPGAEE AQDPEGKGEQ EHSQQKEEEE EMAVVPQGLF RGGKSGELEQ EEERLSKEWE DSKRWSKMDQ LAKELTAEKR LEGQEEEEDN RDSSMKLSFR ARAYGFRGPG PQLRRGWRPS SREDSLEAGL PLQVRGYPEE KKEEEGSANR RPEDQELESL SAIEAELEKV AHQLQALRRG

Host

E Coli

Form/Format

Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 2mM EDTA, 0.1mM PMSF, 10% glycerol

Purity/Purification

> 80% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 2°C to 8°C for 1 week.
For long term storage, aliquot and store at -20°C to -80°C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

51.2 kDa (460aa) (Molecular weight on SDS-PAGE will appear higher)

OMIM

J03483 mRNA

3D Structure

ModBase 3D Structure for P10645

Tag Information

His-tag

Product Categories/Family for CHGA recombinant protein

Cancer

Applications Tested/Suitable for CHGA recombinant protein

SDS-PAGE

Product References and Citations for CHGA recombinant protein

Montero-Hadjadje M., et al. (2009). J Biol Chem. 284 (18):12420-31.; Hendy GN., et al. (1995). Clin Invest Med. 18 (1):47-65;

Other Notes

Small volumes of CHGA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHGA purchase

MBS203324 is a recombinant protein targeting CHGA. Also known as Chromogranin-A, 19-457aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CHGA. It may not necessarily be applicable to this product.

NCBI GI #

4502805

NCBI GeneID

1113

NCBI Accession #

NP_001266

UniProt Primary Accession #

P10645

UniProt Secondary Accession #

Q53FA8; Q6NR84; Q96E84; Q96GL7; Q9BQB5; B2R9E9

UniProt Related Accession #

P10645

GenBank Nucleotide #

NM_001275.3

NCBI Official Full Name

chromogranin-A isoform 1 preproprotein

NCBI Official Synonym Full Names

chromogranin A

NCBI Official Symbol

CHGA

NCBI Official Synonym Symbols

CGA

UniProt Protein Name

Chromogranin-A

UniProt Synonym Protein Names

SL21

Protein Family

Chromogranin

UniProt Gene Name

CHGA

UniProt Synonym Gene Names

CgA; SP-I

NCBI Protein Information

chromogranin-A

NCBI Summary for CHGA

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

UniProt Comments for CHGA

Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).

Research Articles on CHGA

1. Results show that chronic lymphocytic leukemia (CLL) patients had increased plasma levels of chromogranin A (CgA), compared to normal subjects, particularly those >70-year-old or those treated with proton pump inhibitors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CHGA recombinant protein

Reference Product	PubMed Publications
CHGB recombinant protein	>32 publications with CHGA and CHGB
SYP recombinant protein	>25 publications with CHGA and SYP
SCG2 recombinant protein	>3 publications with CHGA and SCG2
GAST recombinant protein	>2 publications with CHGA and GAST
CALCA recombinant protein	>1 publications with CHGA and CALCA
SST recombinant protein	>1 publications with CHGA and SST
SCG3 recombinant protein	>1 publications with CHGA and SCG3

Pathways associated with CHGA recombinant protein

Products by Pathway	Pathway Diagram
Antimicrobial Peptides Pathway antibodies	Antimicrobial Peptides Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram

Diseases associated with CHGA recombinant protein

Disease Name	Pubmed Publications
Hypertension Antibodies	>69 publications with CHGA and Hypertension
Cardiovascular Diseases Antibodies	>66 publications with CHGA and Cardiovascular Diseases
Pheochromocytoma Antibodies	>64 publications with CHGA and Pheochromocytoma
Nervous System Diseases Antibodies	>47 publications with CHGA and Nervous System Diseases
Hyperplasia Antibodies	>30 publications with CHGA and Hyperplasia
Kidney Diseases Antibodies	>27 publications with CHGA and Kidney Diseases
Carcinoma, Non-Small-Cell Lung Antibodies	>25 publications with CHGA and Carcinoma, Non-Small-Cell Lung
Diabetes Mellitus Antibodies	>21 publications with CHGA and Diabetes Mellitus
Liver Diseases Antibodies	>21 publications with CHGA and Liver Diseases
Inflammation Antibodies	>15 publications with CHGA and Inflammation

Organs/Tissues associated with CHGA recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>105 publications with CHGA and Nerve
Adrenal Gland Antibodies	>87 publications with CHGA and Adrenal Gland
Prostate Antibodies	>58 publications with CHGA and Prostate
Lung Antibodies	>53 publications with CHGA and Lung
Stomach Antibodies	>53 publications with CHGA and Stomach
Brain Antibodies	>53 publications with CHGA and Brain
Thyroid Antibodies	>45 publications with CHGA and Thyroid
Pancreas Antibodies	>41 publications with CHGA and Pancreas
Intestine Antibodies	>33 publications with CHGA and Intestine
Parathyroid Antibodies	>29 publications with CHGA and Parathyroid