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WWOX Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203331

WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
WWOX, Recombinant Protein
Full Product Name
WWOX, 1-234aa, Human, His tag, E Coli
Product Gene Name
WWOX recombinant protein
Product Synonym Names
WW domain containing oxidoreductase; WW domain containing oxidoreductase; D16S432E; FOR; FRA16D; HHCMA56; PRO0128; SDR41C1; WOX1; WW domain containing oxidoreductase 5330426P09Rik; 9030416C10Rik; EC 1.1.1.- Fragile site FRA16D Oxireductase; MGC55975; PRO0128; Putative oxidoreductase; zgc:55975; Short chain dehydrogenase/reductase family 41C; member 1; WW domain-containing protein WWOX.
Sequence
MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG
Host
E Coli
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
Purity/Purification
> 85% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
28.3 kDa (254aa), confirmed by MALDI-TOF.
OMIM
AF211943 mRNA
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for WWOX recombinant protein

Redox Proteins
Applications Tested/Suitable for WWOX recombinant protein
SDS-PAGE

SDS-Page of WWOX recombinant protein

WWOX Recombinant Protein – Cat# MBS203331

Product References and Citations for WWOX recombinant protein

Bouteille N., et al. (2009), Oncogene. 28 (28):2569-80.; Gourley C., et al. (2009). Cancer Res. 69 (11):4835-42.;

Other Notes

Small volumes of WWOX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WWOX purchase

MBS203331 is a recombinant protein targeting WWOX. Also known as WWOX, 1-234aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for WWOX. It may not necessarily be applicable to this product.

NCBI GI #
13112021
NCBI GeneID
51741
NCBI Accession #
AAH03184
UniProt Secondary Accession #
Q5MYT5; Q96KM3; Q96RF2; Q9BTT8; Q9NPC9; Q9NRF4; Q9NRF5; Q9NRF6; Q9NRK1; Q9NZC5; A8K323
UniProt Related Accession #
Q9NZC7
NCBI Official Full Name
WWOX protein
NCBI Official Synonym Full Names
WW domain containing oxidoreductase
NCBI Official Symbol
WWOX
NCBI Official Synonym Symbols
FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E
UniProt Protein Name
WW domain-containing oxidoreductase
UniProt Synonym Protein Names
Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1
Protein Family
WW domain-containing oxidoreductase
UniProt Gene Name
WWOX
UniProt Synonym Gene Names
FOR; SDR41C1; WOX1
NCBI Protein Information
WW domain-containing oxidoreductase

NCBI Summary for WWOX

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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UniProt Comments for WWOX

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
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Research Articles on WWOX

1. WWOX expression was strongly inhibited in human lung cancers and lung cancer cell lines. Reintroducing WWOX into lung cancer cells inhibited their invasive phenotype through downregulating RUNX2 and its target genes including MMP-9 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with WWOX recombinant protein

 Reference Product  PubMed Publications
 TP53 recombinant protein  >13 publications with WWOX and TP53
 SMAD4 recombinant protein  >11 publications with WWOX and SMAD4
 MAPK8 recombinant protein  >6 publications with WWOX and MAPK8
 TFAP2C recombinant protein  >5 publications with WWOX and TFAP2C
 SRC recombinant protein  >3 publications with WWOX and SRC
 YAP1 recombinant protein  >3 publications with WWOX and YAP1

Pathways associated with WWOX recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of The TFAP2 (AP-2) Family Of Transcription Factors Pathway antibodies  Activation Of The TFAP2 (AP-2) Family Of Transcription Factors Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Negative Regulation Of Activity Of TFAP2 (AP-2) Family Transcription Factors Pathway antibodies  Negative Regulation Of Activity Of TFAP2 (AP-2) Family Transcription Factors Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By ERBB4 Pathway antibodies  Signaling By ERBB4 Pathway Diagram
 Transcriptional Regulation By The AP-2 (TFAP2) Family Of Transcription Factors Pathway antibodies  Transcriptional Regulation By The AP-2 (TFAP2) Family Of Transcription Factors Pathway Diagram

Diseases associated with WWOX recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >64 publications with WWOX and Breast Neoplasms
 Adenocarcinoma Antibodies  >52 publications with WWOX and Adenocarcinoma
 Lung Neoplasms Antibodies  >36 publications with WWOX and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >30 publications with WWOX and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >25 publications with WWOX and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >24 publications with WWOX and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >22 publications with WWOX and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >20 publications with WWOX and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >19 publications with WWOX and Liver Neoplasms
 Disease Models, Animal Antibodies  >18 publications with WWOX and Disease Models, Animal

Organs/Tissues associated with WWOX recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >49 publications with WWOX and Lung
 Brain Antibodies  >34 publications with WWOX and Brain
 Prostate Antibodies  >32 publications with WWOX and Prostate
 Bone Antibodies  >31 publications with WWOX and Bone
 Blood Antibodies  >24 publications with WWOX and Blood
 Liver Antibodies  >24 publications with WWOX and Liver
 Lymph Antibodies  >15 publications with WWOX and Lymph
 Kidney Antibodies  >9 publications with WWOX and Kidney
 Ovary Antibodies  >8 publications with WWOX and Ovary
 Nerve Antibodies  >6 publications with WWOX and Nerve
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