3ug by SDS-PAGE under reducing condition and visualized fby coomassie blue stain.

Peroxiredoxin 6 (PRDX6) Active Protein

Name: PRDX6 Active Protein; Peroxiredoxin 6; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203357
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203357

Specific activity is >2,000 pmol/min/ug. Enzymatic activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for 1minute. More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Peroxiredoxin 6 (PRDX6), Active Protein

Full Product Name

Peroxiredoxin 6, 1-224aa, Human, His tag, E Coli (Bioactivity Validated)

Product Gene Name

PRDX6 active protein

Product Synonym Names

1-Cys; aiPLA2; AOP2; NSGPx; p29; PRX; Peroxiredoxin6; PRDX6; PRDX 6; PRDX-6; AA690119; Prdx6 rs3; 1 Cys; 1 Cys peroxiredoxin; 1 Cys PRX; 1 cysPrx; 24 kDa protein; 9430088D19Rik; Acidic calcium independent phospholipase A2; Antioxidant protein 2; Aop2 rs3; Brp 12; mKIAA0106; Ciliary body glutathione peroxidase; CP 3; EC 1.11.1.15; EC 1.11.1.7; EC 3.1.1; GPx; KIAA0106; Liver 2D page spot 40; Ltw4; Lvtw 4; MGC46173; Non selenium glutathione peroxidase; NSGPx; ORF06; OTTHuMP00000032693; Peroxiredoxin6; PHGPx; Phospholipase A2 lysosomal; PLA2; Prdx5; PRX; Red blood cells page spot 12; Thiol specific antioxidant protein

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Molecular Weight

27.1 kDa (244aa), confirmed by MALDI-TOF.

OMIM

D14662 mRNA

3D Structure

ModBase 3D Structure for P30041

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Domain

1-224aa

Tag Information

His-tag

Product Categories/Family for PRDX6 active protein

Redox Proteins

Applications Tested/Suitable for PRDX6 active protein

Enzyme Activity, SDS-PAGE

Product References and Citations for PRDX6 active protein

Davison EJ., et al. (2009). Proteomics. 9 (18):4284-97.; Wu J., et al. (2009). Chem Res Toxicol. 22 (4):668-75.;

Other Notes

Small volumes of PRDX6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX6 purchase

MBS203357 is an active protein targeting PRDX6. Also known as Peroxiredoxin 6, 1-224aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX6. It may not necessarily be applicable to this product.

NCBI GI #

4758638

NCBI GeneID

9588

NCBI Accession #

NP_004896

UniProt Primary Accession #

P30041

UniProt Secondary Accession #

P32077; Q5TAH4; Q5ZEZ8; A8JZY7

UniProt Related Accession #

P30041

GenBank Nucleotide #

NM_004905.2

NCBI Official Full Name

peroxiredoxin-6

NCBI Official Synonym Full Names

peroxiredoxin 6

NCBI Official Symbol

PRDX6

NCBI Official Synonym Symbols

PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m

UniProt Protein Name

Peroxiredoxin-6

UniProt Synonym Protein Names

1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2 (EC:3.1.1.4

Protein Family

Peroxiredoxin

UniProt Gene Name

PRDX6

UniProt Synonym Gene Names

AOP2; KIAA0106; aiPLA2; NSGPx

NCBI Protein Information

peroxiredoxin-6

NCBI Summary for PRDX6

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

UniProt Comments for PRDX6

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.

Research Articles on PRDX6

1. the transition-state substrate analogue inhibitor of Prdx6 phospholipase A2 activity (MJ-33) was shown to suppress Nox1 activity, suggesting Nox1 activity is regulated by the phospholipase activity of Prdx6. Finally, wild type Prdx6, but not lipase or peroxidase mutant forms, supports Nox1-mediated cell migration in the HCT-116 colon epithelial cell model of wound closure

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRDX6 active protein

Reference Product	PubMed Publications
PRDX2 active protein	>19 publications with PRDX6 and PRDX2
PRDX5 active protein	>14 publications with PRDX6 and PRDX5
CAT active protein	>9 publications with PRDX6 and CAT
GSTP1 active protein	>8 publications with PRDX6 and GSTP1
TXN active protein	>3 publications with PRDX6 and TXN
TXN2 active protein	>2 publications with PRDX6 and TXN2
PDIA3 active protein	>2 publications with PRDX6 and PDIA3

Pathways associated with PRDX6 active protein

Products by Pathway	Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
NRF2 Pathway antibodies	NRF2 Pathway Diagram
Neutrophil Degranulation Pathway antibodies	Neutrophil Degranulation Pathway Diagram

Diseases associated with PRDX6 active protein

Disease Name	Pubmed Publications
Death Antibodies	>42 publications with PRDX6 and Death
Nervous System Diseases Antibodies	>30 publications with PRDX6 and Nervous System Diseases
Disease Models, Animal Antibodies	>28 publications with PRDX6 and Disease Models, Animal
Inflammation Antibodies	>25 publications with PRDX6 and Inflammation
Lung Injury Antibodies	>17 publications with PRDX6 and Lung Injury
Lung Neoplasms Antibodies	>12 publications with PRDX6 and Lung Neoplasms
Necrosis Antibodies	>11 publications with PRDX6 and Necrosis
Liver Diseases Antibodies	>10 publications with PRDX6 and Liver Diseases
Atherosclerosis Antibodies	>8 publications with PRDX6 and Atherosclerosis
Liver Neoplasms Antibodies	>8 publications with PRDX6 and Liver Neoplasms

Organs/Tissues associated with PRDX6 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>65 publications with PRDX6 and Lung
Brain Antibodies	>45 publications with PRDX6 and Brain
Blood Antibodies	>44 publications with PRDX6 and Blood
Liver Antibodies	>37 publications with PRDX6 and Liver
Eye Antibodies	>21 publications with PRDX6 and Eye
Vascular Antibodies	>20 publications with PRDX6 and Vascular
Muscle Antibodies	>16 publications with PRDX6 and Muscle
Nerve Antibodies	>15 publications with PRDX6 and Nerve
Kidney Antibodies	>15 publications with PRDX6 and Kidney
Skin Antibodies	>8 publications with PRDX6 and Skin