3 ug by SDS-PAGE under reducing coditions and visualized by coomassie blue stain.

RAC2 Recombinant Protein

Name: RAC2 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203366
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203366

Rac2 is a small signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. Rac proteins play important roles in multiple cellular events, including actin cytoskeletal organization, cell… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RAC2, Recombinant Protein

Full Product Name

RAC2, 1-189aa, Human, His tag, E Coli

Product Gene Name

RAC2 recombinant protein

Product Synonym Names

Ras-related C3 botulinum toxin substrate 2.; EN-7; Gx; HSPC022; Ras-related C3 botulinum toxin substrate 2; EN 7; EN7; HSPC 022; p21 Rac 2; p21 Rac2; p21Rac2; RAC 2; Ras related C3 botulinum toxin substrate 2; Ras related C3 botulinum toxin substrate 3; Rho family small GTP binding protein Rac 2; Rho family small GTP binding protein Rac2; Small G protein.

Sequence

MGSSHHHHHH SSGLVPRGSH MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKEID SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRAC

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol 2mM EDTA, 2mM DTT, 0.1 M NaCl.

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 2-8°C for 1 week.
For long term storage, aliquot and store at -20°C or -80°C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

23.3 kDa (209aa), confirmed by MALDI-TOF.

Sequence Positions

1-189aa

OMIM

M29871 mRNA

3D Structure

ModBase 3D Structure for P15153

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for RAC2 recombinant protein

Signal Transduction

Applications Tested/Suitable for RAC2 recombinant protein

SDS-PAGE

Product References and Citations for RAC2 recombinant protein

Ambruso DR., et al. (2000) Proc Natl Acad Sci u S A. 97 (9):4654-9. ; Faure J., et al. (2001) Biochimie. 83 (5):409-14.;

Other Notes

Small volumes of RAC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAC2 purchase

MBS203366 is a recombinant protein targeting RAC2. Also known as RAC2, 1-189aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RAC2. It may not necessarily be applicable to this product.

NCBI GI #

4506381

NCBI GeneID

5880

NCBI Accession #

NP_002863

UniProt Primary Accession #

P15153

UniProt Secondary Accession #

Q9UDJ4

UniProt Related Accession #

P15153

GenBank Nucleotide #

NM_002872.4

NCBI Official Full Name

ras-related C3 botulinum toxin substrate 2

NCBI Official Synonym Full Names

Rac family small GTPase 2

NCBI Official Symbol

RAC2

NCBI Official Synonym Symbols

Gx; EN-7; HSPC022; p21-Rac2

UniProt Protein Name

Ras-related C3 botulinum toxin substrate 2

UniProt Synonym Protein Names

GX; Small G protein; p21-Rac2

Protein Family

Rac-like GTP-binding protein

UniProt Gene Name

RAC2

NCBI Protein Information

ras-related C3 botulinum toxin substrate 2

NCBI Summary for RAC2

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

UniProt Comments for RAC2

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.

Research Articles on RAC2

1. We found both the rs229527 allele within C1QTNF6 (odds ratio [OR] = 1.23, confidence interval [95% CI]: 1.12-1.33, pAllelic = 4.60 . 10-6) and the rs2284038 allele within RAC2 (OR = 1.10, 95% CI: 1.01-0.19, pAllelic = 3.00 . 10-2) showed significant associations with Graves' Disease susceptibility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RAC2 recombinant protein

Reference Product	PubMed Publications
VAV1 recombinant protein	>26 publications with RAC2 and VAV1
CYBB recombinant protein	>21 publications with RAC2 and CYBB
PAK1 recombinant protein	>13 publications with RAC2 and PAK1
DOCK2 recombinant protein	>6 publications with RAC2 and DOCK2
PAK2 recombinant protein	>5 publications with RAC2 and PAK2
NCF2 recombinant protein	>5 publications with RAC2 and NCF2
ARHGDIB recombinant protein	>5 publications with RAC2 and ARHGDIB
PIK3CB recombinant protein	>3 publications with RAC2 and PIK3CB
ARHGDIA recombinant protein	>2 publications with RAC2 and ARHGDIA
ARHGDIG recombinant protein	>1 publications with RAC2 and ARHGDIG

Pathways associated with RAC2 recombinant protein

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B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Beta-catenin Independent WNT Signaling Pathway antibodies	Beta-catenin Independent WNT Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram

Diseases associated with RAC2 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>66 publications with RAC2 and Inflammation
Neutrophil Immunodeficiency Syndrome Antibodies	>19 publications with RAC2 and Neutrophil Immunodeficiency Syndrome
Lymphoma Antibodies	>17 publications with RAC2 and Lymphoma
Disease Models, Animal Antibodies	>16 publications with RAC2 and Disease Models, Animal
Lung Diseases Antibodies	>12 publications with RAC2 and Lung Diseases
Necrosis Antibodies	>11 publications with RAC2 and Necrosis
Neoplasm Metastasis Antibodies	>11 publications with RAC2 and Neoplasm Metastasis
Cell Transformation, Neoplastic Antibodies	>10 publications with RAC2 and Cell Transformation, Neoplastic
Breast Neoplasms Antibodies	>7 publications with RAC2 and Breast Neoplasms
Heart Diseases Antibodies	>7 publications with RAC2 and Heart Diseases

Organs/Tissues associated with RAC2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>283 publications with RAC2 and Blood
Bone Antibodies	>83 publications with RAC2 and Bone
Bone Marrow Antibodies	>68 publications with RAC2 and Bone Marrow
Vascular Antibodies	>30 publications with RAC2 and Vascular
Lung Antibodies	>20 publications with RAC2 and Lung
Brain Antibodies	>18 publications with RAC2 and Brain
Heart Antibodies	>15 publications with RAC2 and Heart
Spleen Antibodies	>14 publications with RAC2 and Spleen
Liver Antibodies	>12 publications with RAC2 and Liver
Eye Antibodies	>12 publications with RAC2 and Eye