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LSM1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203432

u6 snRNA-associated Sm-like protein LSm1, also known as LSM1 plays a role in replication-dependent histone mRNA degradation and binds specifically to the 3'-terminal u-tract of u6 snRNA. LSM1 protein facilitates RNA protein interactions and structural changes… More details

$230 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LSM1, Recombinant Protein
Full Product Name
LSM1, 1-133aa, Human, His tag, E Coli
Product Gene Name
Product Synonym Names
u6 snRNA-associated Sm-like protein LSm1; CASM; Small nuclear ribonuclear CaSm; u6 snRNA-associated Sm-like protein LSm1
Sequence
MGSSHHHHHH SSGLVPRGSH MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI HVGKKYGDIP RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR VEQQTKLEAE KLKVQALKDR GLSIPRADTL DEY
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 7.5) containing 1mM DTT, 10% glycerol, 0.1M NaCl
Purity/Purification
> 95% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
17.3kDa (153aa), confirmed by MALDI-TOF
OMIM
AF000177 mRNA
3D Structure
ModBase 3D Structure for O15116
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for LSM1 recombinant protein

Applications Tested/Suitable for LSM1 recombinant protein
SDS-PAGE

Product References and Citations for LSM1 recombinant protein

Noueiry A O., et al. (2003) Mol Cell Biol. 23:4094-4106.; Kufel J., et al. (2003) J Biol Chem. 278:2147-2156.;

Other Notes

Small volumes of LSM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LSM1 purchase

MBS203432 is a recombinant protein targeting LSM1. Also known as LSM1, 1-133aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LSM1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
U6 snRNA-associated Sm-like protein LSm1
NCBI Official Synonym Full Names
LSM1 homolog, mRNA degradation associated
NCBI Official Symbol
LSM1
NCBI Official Synonym Symbols
CASM; YJL124C
UniProt Protein Name
U6 snRNA-associated Sm-like protein LSm1
UniProt Synonym Protein Names
Cancer-associated Sm-like; Small nuclear ribonuclear CaSm
UniProt Gene Name
LSM1
UniProt Synonym Gene Names
CASM
NCBI Protein Information
U6 snRNA-associated Sm-like protein LSm1

NCBI Summary for LSM1

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
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UniProt Comments for LSM1

Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation ().

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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