SORD Active Protein

Name: SORD Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203476
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203476

SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family. It is widely expressed with highest expression in kidney and in the lens of the eye. SORD enzymatically catalyzes the… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SORD, Active Protein

Full Product Name

SORD, 1-357aa, Human, His tag, E Coli (Bioactivity Validated)

Product Gene Name

SORD active protein

Product Synonym Names

Sorbitol dehydrogenase; Sorbitol dehydrogenase L iditol 2 dehydrogenase; SDH; SORD; SORD 1; SORD1

Sequence

MGSSHHHHHH SSGLVPRGSH MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIKGVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

40.4 kDa (377aa) confirmed by MALDI-TOF

OMIM

U07361 mRNA

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Antigen Species

Human

Tag Information

His-tag

Biological Activity

Specific activity is > 20,000 pmol/min/ug, and is defined as the amount of enzyme that catalyze D-fructose to D-sorbitol per minute at pH 7.5 at 37C.

Product Categories/Family for SORD active protein

Metabolism

Applications Tested/Suitable for SORD active protein

SDS-PAGE

Product References and Citations for SORD active protein

Baker MA., et al. (2010) Proteomics. 10 (3):482-95. ; Sorger D., et al. (2009) Nucl Med Biol. 36 (1):17-27.;

Other Notes

Small volumes of SORD active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SORD purchase

MBS203476 is an active protein targeting SORD. Also known as SORD, 1-357aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SORD. It may not necessarily be applicable to this product.

NCBI GI #

19263809

NCBI GeneID

6652

NCBI Accession #

AAH25295

UniProt Secondary Accession #

Q16682; Q9UMD6; B2R655; B7Z3A6; J3JZZ5

UniProt Related Accession #

Q00796

NCBI Official Full Name

Sorbitol dehydrogenase

NCBI Official Synonym Full Names

sorbitol dehydrogenase

NCBI Official Symbol

SORD

NCBI Official Synonym Symbols

SORD1; HEL-S-95n

UniProt Protein Name

Sorbitol dehydrogenase

UniProt Synonym Protein Names

L-iditol 2-dehydrogenase

Protein Family

PTS system sorbose-specific EIID component

UniProt Gene Name

SORD

NCBI Protein Information

sorbitol dehydrogenase

NCBI Summary for SORD

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]

UniProt Comments for SORD

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.

Research Articles on SORD

1. SDH gene expression was increased by hypoxia and oxidative stress, but not extracellular hyperosmolarity. Hyperosmolarity and hypoxia did not alter the SDH protein level.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SORD active protein

Reference Product	PubMed Publications
AKR1B1 active protein	>3 publications with SORD and AKR1B1
HK1 active protein	>2 publications with SORD and HK1
CAT active protein	>1 publications with SORD and CAT
KHK active protein	>1 publications with SORD and KHK

Pathways associated with SORD active protein

Products by Pathway	Pathway Diagram
Catabolism Of Glucuronate To Xylulose-5-phosphate Pathway antibodies	Catabolism Of Glucuronate To Xylulose-5-phosphate Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Fructose Biosynthesis Pathway antibodies	Fructose Biosynthesis Pathway Diagram
Fructose Metabolism Pathway antibodies	Fructose Metabolism Pathway Diagram
Glucuronate Pathway (uronate Pathway) antibodies	Glucuronate Pathway (uronate Pathway) Diagram
Glucuronate Pathway (uronate Pathway) antibodies	Glucuronate Pathway (uronate Pathway) Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Carbohydrates Pathway antibodies	Metabolism Of Carbohydrates Pathway Diagram

Diseases associated with SORD active protein

Disease Name	Pubmed Publications
Infertility, Male Antibodies	>2 publications with SORD and Infertility, Male
Liver Diseases Antibodies	>2 publications with SORD and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with SORD and Carcinoma, Hepatocellular
Neoplasms, Experimental Antibodies	>1 publications with SORD and Neoplasms, Experimental
Lung Neoplasms Antibodies	>1 publications with SORD and Lung Neoplasms
Hyperglycemia Antibodies	>1 publications with SORD and Hyperglycemia
Liver Neoplasms Antibodies	>1 publications with SORD and Liver Neoplasms
Kidney Diseases Antibodies	>1 publications with SORD and Kidney Diseases
Inflammation Antibodies	>1 publications with SORD and Inflammation

Organs/Tissues associated with SORD active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>14 publications with SORD and Blood
Brain Antibodies	>8 publications with SORD and Brain
Eye Antibodies	>4 publications with SORD and Eye
Liver Antibodies	>4 publications with SORD and Liver
Lung Antibodies	>3 publications with SORD and Lung
Kidney Antibodies	>3 publications with SORD and Kidney
Vascular Antibodies	>3 publications with SORD and Vascular
Testis Antibodies	>2 publications with SORD and Testis
Muscle Antibodies	>2 publications with SORD and Muscle
Uterus Antibodies	>1 publications with SORD and Uterus