GLUL Recombinant Protein

Name: GLUL Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203490
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203490

Glutamine synthetase (GLuL), which is therefore able to regulate intracellular concentrations of glutamate. GLuL catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation,… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GLUL, Recombinant Protein

Full Product Name

GLuL, 1-373aa, Human, His tag, E Coli

Product Gene Name

GLUL recombinant protein

Product Synonym Names

Glutamine synthetase; GS; GLNS; Glutamine synthetase; Glutamate-ammonia ligase; Glutamate decarboxylase

Sequence

MGSSHHHHHH SSGLVPRGSH MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS VTEALIRTCL LNETGDEPFQ YKN

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 5mM DTT, 200mM NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

44.2kDa (393aa), confirmed by MALDI-TOF

OMIM

Y00387 mRNA

3D Structure

ModBase 3D Structure for P15104

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for GLUL recombinant protein

Enzymes & Proteases

Applications Tested/Suitable for GLUL recombinant protein

SDS-PAGE

Product References and Citations for GLUL recombinant protein

Vermeulen T., et al, (2008) Arch Biochem Biophys. 478:96-102; Liaw SH., et al. (1995) Protein Sci. 4 (11): 2358-65.;

Other Notes

Small volumes of GLUL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLUL purchase

MBS203490 is a recombinant protein targeting GLUL. Also known as GLuL, 1-373aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GLUL. It may not necessarily be applicable to this product.

NCBI GI #

74271837

NCBI GeneID

2752

NCBI Accession #

NP_001028216

UniProt Primary Accession #

P15104

UniProt Secondary Accession #

Q499Y9; Q5T9Z1; Q7Z3W4; Q8IZ17

UniProt Related Accession #

P15104

GenBank Nucleotide #

NM_001033044.3

NCBI Official Full Name

glutamine synthetase

NCBI Official Synonym Full Names

glutamate-ammonia ligase

NCBI Official Symbol

GLUL

NCBI Official Synonym Symbols

GS; GLNS; PIG43; PIG59

UniProt Protein Name

Glutamine synthetase

UniProt Synonym Protein Names

Glutamate decarboxylase (EC:4.1.1.15); Glutamate--ammonia ligase

UniProt Gene Name

GLUL

UniProt Synonym Gene Names

GLNS; GS

NCBI Protein Information

glutamine synthetase

NCBI Summary for GLUL

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

UniProt Comments for GLUL

This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (). Essential for proliferation of fetal skin fibroblasts.

Research Articles on GLUL

1. Data show that 1,25-dihydroxyvitamin D (1,25D) downregulation of glutamine synthetase (GLUL; GS)) was sufficient to reduce abundance and enzyme activity of GS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GLUL recombinant protein

Reference Product	PubMed Publications
GLS recombinant protein	>7 publications with GLUL and GLS
GLUD1 recombinant protein	>4 publications with GLUL and GLUD1
CPS1 recombinant protein	>4 publications with GLUL and CPS1
GAD1 recombinant protein	>3 publications with GLUL and GAD1
GAD2 recombinant protein	>2 publications with GLUL and GAD2
ABAT recombinant protein	>1 publications with GLUL and ABAT
CAD recombinant protein	>1 publications with GLUL and CAD

Pathways associated with GLUL recombinant protein

Products by Pathway	Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Amino Acid Metabolism Pathway antibodies	Amino Acid Metabolism Pathway Diagram
Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies	Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
Arginine Biosynthesis Pathway antibodies	Arginine Biosynthesis Pathway Diagram
Arginine Biosynthesis Pathway antibodies	Arginine Biosynthesis Pathway Diagram
Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway antibodies	Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
GABA Shunt Pathway antibodies	GABA Shunt Pathway Diagram

Diseases associated with GLUL recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>14 publications with GLUL and Liver Diseases
Death Antibodies	>10 publications with GLUL and Death
Liver Neoplasms Antibodies	>10 publications with GLUL and Liver Neoplasms
Brain Diseases Antibodies	>9 publications with GLUL and Brain Diseases
Carcinoma, Hepatocellular Antibodies	>8 publications with GLUL and Carcinoma, Hepatocellular
Obesity Antibodies	>5 publications with GLUL and Obesity
Heart Diseases Antibodies	>5 publications with GLUL and Heart Diseases
Weight Loss Antibodies	>4 publications with GLUL and Weight Loss
Breast Neoplasms Antibodies	>4 publications with GLUL and Breast Neoplasms
Disease Models, Animal Antibodies	>3 publications with GLUL and Disease Models, Animal

Organs/Tissues associated with GLUL recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>22 publications with GLUL and Brain
Eye Antibodies	>7 publications with GLUL and Eye