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FBL Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203507

FBL is a key small nucleolar protein in eukaryotes, which has an important role in pre-rRNA processing during ribosomal biogenesis. It is associated with the u3, u8, and u13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FBL, Recombinant Protein
Full Product Name
FBL, 83-321aa, Human, His tag, E Coli
Product Gene Name
FBL recombinant protein
Product Synonym Names
rRNA 2'-O-methyltransferase fibrillarin; FIB; FLRN; RNu3IP1; rRNA 2'-O-methyltransferase fibrillarin
Sequence
MGSSHHHHHH SSGLVPRGSH RSMGKNVMVE PHRHEGVFIC RGKEDALVTK NLVPGESVYG EKRVSISEGD DKIEYRAWNP FRSKLAAAIL GGVDQIHIKP GAKVLYLGAA SGTTVSHVSD IVGPDGLVYA VEFSHRSGRD LINLAKKRTN IIPVIEDARH PHKYRMLIAM VDVIFADVAQ PDQTRIVALN AHTFLRNGGH FVISIKANCI DSTASAEAVF ASEVKKMQQE NMKPQEQLTL EPYERDHAVV VGVYRPPPKV KN
Host
E Coli
Form/Format
Liquid. In phosphate buffered saline (pH 7.4)containing 30% glycerol, 1mM EDTA.
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
28.9 kDa (262aa), confirmed by MALDI-TOF
OMIM
M59849 mRNA
3D Structure
ModBase 3D Structure for P22087
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for FBL recombinant protein

Enzymes & Proteases
Applications Tested/Suitable for FBL recombinant protein
SDS-PAGE

SDS-Page of FBL recombinant protein

FBL Recombinant Protein – Cat# MBS203507

Product References and Citations for FBL recombinant protein

Amin MA, et al. (2007) Biochem Biophys Res Commun. 360 (2):320-6; Jansen RP, et al. (1991) J Cell Biol 113 (4): 715-29;

Other Notes

Small volumes of FBL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBL purchase

MBS203507 is a recombinant protein targeting FBL. Also known as FBL, 83-321aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FBL. It may not necessarily be applicable to this product.

NCBI GI #
12056465
NCBI GeneID
2091
NCBI Accession #
NP_001427
UniProt Primary Accession #
P22087
UniProt Secondary Accession #
O75259; Q6IAT5; Q9UPI6; B5BUE8
UniProt Related Accession #
P22087
GenBank Nucleotide #
NM_001436.3
NCBI Official Full Name
rRNA 2'-O-methyltransferase fibrillarin
NCBI Official Synonym Full Names
fibrillarin
NCBI Official Symbol
FBL
NCBI Official Synonym Symbols
FIB; FLRN; Nop1; RNU3IP1
UniProt Protein Name
rRNA 2'-O-methyltransferase fibrillarin
UniProt Synonym Protein Names
34 kDa nucleolar scleroderma antigen; Histone-glutamine methyltransferase
Protein Family
rRNA 2'-O-methyltransferase fibrillarin
UniProt Gene Name
FBL
UniProt Synonym Gene Names
FIB1; FLRN
NCBI Protein Information
rRNA 2'-O-methyltransferase fibrillarin

NCBI Summary for FBL

This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
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UniProt Comments for FBL

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).
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Research Articles on FBL

1. Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FBL recombinant protein

 Reference Product  PubMed Publications
 NOP56 recombinant protein  >4 publications with FBL and NOP56
 NOP58 recombinant protein  >3 publications with FBL and NOP58
 DKC1 recombinant protein  >1 publications with FBL and DKC1
 NHP2L1 recombinant protein  >1 publications with FBL and NHP2L1

Pathways associated with FBL recombinant protein

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Major Pathway Of RRNA Processing In The Nucleolus And Cytosol antibodies  Major Pathway Of RRNA Processing In The Nucleolus And Cytosol Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 RRNA Modification In The Nucleus And Cytosol Pathway antibodies  RRNA Modification In The Nucleus And Cytosol Pathway Diagram
 RRNA Processing Pathway antibodies  RRNA Processing Pathway Diagram
 RRNA Processing In The Nucleus And Cytosol Pathway antibodies  RRNA Processing In The Nucleus And Cytosol Pathway Diagram

Diseases associated with FBL recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >63 publications with FBL and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >10 publications with FBL and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >9 publications with FBL and Nervous System Diseases
 Brain Diseases Antibodies  >8 publications with FBL and Brain Diseases
 Breast Neoplasms Antibodies  >6 publications with FBL and Breast Neoplasms
 Necrosis Antibodies  >5 publications with FBL and Necrosis
 Heart Diseases Antibodies  >4 publications with FBL and Heart Diseases
 Lung Diseases Antibodies  >4 publications with FBL and Lung Diseases
 Hemorrhage Antibodies  >4 publications with FBL and Hemorrhage
 Fibrosis Antibodies  >2 publications with FBL and Fibrosis

Organs/Tissues associated with FBL recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >105 publications with FBL and Blood
 Spleen Antibodies  >48 publications with FBL and Spleen
 Brain Antibodies  >17 publications with FBL and Brain
 Muscle Antibodies  >16 publications with FBL and Muscle
 Lymph Antibodies  >16 publications with FBL and Lymph
 Lymph Node Antibodies  >16 publications with FBL and Lymph Node
 Bone Antibodies  >12 publications with FBL and Bone
 Lung Antibodies  >10 publications with FBL and Lung
 Liver Antibodies  >8 publications with FBL and Liver
 Thymus Antibodies  >6 publications with FBL and Thymus
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