CASQ2 Recombinant Protein – Cat# MBS203543

Calsequestrin-2 (CASQ2) Recombinant Protein

Name: CASQ2 Recombinant Protein; Calsequestrin-2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203543
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203543

Calsequestrin2 is a calcium-binding protein of the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Calsequestrin-2 (CASQ2), Recombinant Protein

Full Product Name

Calsequestrin-2, 20-399aa, Human, His tag, E Coli

Product Gene Name

CASQ2 recombinant protein

Product Synonym Names

PDIB2; CASQ2; Calsequestrin 2 (cardiac muscle); Calsequestrin 2 fast twitch cardiac muscle; Calsequestrin cardiac muscle isoform; Calsequestrin fast twitch cardiac muscle; Calsequestrin2; Cardiac calsequestrin 2; CASQ 2; ESTM52; FLJ26321; FLJ93514; PDIB2.

Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEEG LNFPTYDGKD RVVSLSEKNF KQVLKKYDLL CLYYHEPVSS DKVTQKQFQL KEIVLELVAQ VLEHKAIGFV MVDAKKEAKL AKKLGFDEEG SLYILKGDRT IEFDGEFAAD VLVEFLLDLI EDPVEIISSK LEVQAFERIE DYIKLIGFFK SEDSEYYKAF EEAAEHFQPY IKFFATFDKG VAKKLSLKMN EVDFYEPFMD EPIAIPNKPY TEEELVEFVK EHQRPTLRRL RPEEMFETWE DDLNGIHIVA FAEKSDPDGY EFLEILKQVA RDNTDNPDLS ILWIDPDDFP LLVAYWEKTF KIDLFRPQIG VVNVTDADSV WMEIPDDDDL PTAEELEDWI EDVLSGKINT EDDDEDDDDD DNSDEEDNDD SDDDDDE

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

48.4 kDa (417aa), confirmed by MALDI-TOF.

OMIM

D55655 mRNA

3D Structure

ModBase 3D Structure for O14958

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for CASQ2 recombinant protein

Signal Transduction

Applications Tested/Suitable for CASQ2 recombinant protein

SDS-PAGE

Product References and Citations for CASQ2 recombinant protein

Wang S, et al. (1998) Nat. Struct. Biol.. 5 (6):476-83.; Lahat H, et al. (2001) Am J Hum Genet. 69 (6):1378-84.;

Other Notes

Small volumes of CASQ2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASQ2 purchase

MBS203543 is a recombinant protein targeting CASQ2. Also known as Calsequestrin-2, 20-399aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CASQ2. It may not necessarily be applicable to this product.

NCBI GI #

119395727

NCBI GeneID

845

NCBI Accession #

NP_001223

UniProt Primary Accession #

O14958

UniProt Secondary Accession #

Q5T1D2; Q8TBW8; B2R7M6; B4DIB0

UniProt Related Accession #

O14958

GenBank Nucleotide #

NM_001232.3

NCBI Official Full Name

calsequestrin-2

NCBI Official Synonym Full Names

calsequestrin 2

NCBI Official Symbol

CASQ2

NCBI Official Synonym Symbols

PDIB2

UniProt Protein Name

Calsequestrin-2

UniProt Synonym Protein Names

Calsequestrin, cardiac muscle isoform

Protein Family

Calsequestrin

UniProt Gene Name

CASQ2

NCBI Protein Information

calsequestrin-2

NCBI Summary for CASQ2

The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]

UniProt Comments for CASQ2

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.

Research Articles on CASQ2

1. We show for the first time a heterozygous CASQ2 variant causing autosomal dominant CPVT in a large family with a severe phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CASQ2 recombinant protein

Reference Product	PubMed Publications
RYR2 recombinant protein	>107 publications with CASQ2 and RYR2
TRDN recombinant protein	>16 publications with CASQ2 and TRDN
ASPH recombinant protein	>8 publications with CASQ2 and ASPH
CACNA1C recombinant protein	>3 publications with CASQ2 and CACNA1C
FKBP1B recombinant protein	>2 publications with CASQ2 and FKBP1B
CACNB2 recombinant protein	>1 publications with CASQ2 and CACNB2
CACNA1S recombinant protein	>1 publications with CASQ2 and CACNA1S

Pathways associated with CASQ2 recombinant protein

Products by Pathway	Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram

Diseases associated with CASQ2 recombinant protein

Disease Name	Pubmed Publications
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY Antibodies	>21273 publications with CASQ2 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY
Tachycardia, Ventricular Antibodies	>122 publications with CASQ2 and Tachycardia, Ventricular
Polymorphic catecholergic ventricular tachycardia Antibodies	>49 publications with CASQ2 and Polymorphic catecholergic ventricular tachycardia
Disease Models, Animal Antibodies	>20 publications with CASQ2 and Disease Models, Animal
Cardiomegaly Antibodies	>7 publications with CASQ2 and Cardiomegaly
Inflammation Antibodies	>6 publications with CASQ2 and Inflammation
Heart Defects, Congenital Antibodies	>5 publications with CASQ2 and Heart Defects, Congenital
Congenital Abnormalities Antibodies	>5 publications with CASQ2 and Congenital Abnormalities
Abnormalities, Drug-Induced Antibodies	>4 publications with CASQ2 and Abnormalities, Drug-Induced
Lung Diseases Antibodies	>2 publications with CASQ2 and Lung Diseases

Organs/Tissues associated with CASQ2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>144 publications with CASQ2 and Heart
Muscle Antibodies	>124 publications with CASQ2 and Muscle
Lung Antibodies	>18 publications with CASQ2 and Lung
Brain Antibodies	>6 publications with CASQ2 and Brain
Embryonic Tissue Antibodies	>5 publications with CASQ2 and Embryonic Tissue
Eye Antibodies	>4 publications with CASQ2 and Eye
Skin Antibodies	>2 publications with CASQ2 and Skin
Testis Antibodies	>2 publications with CASQ2 and Testis
Esophagus Antibodies	>1 publications with CASQ2 and Esophagus
Mouth Antibodies	>1 publications with CASQ2 and Mouth