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PFKM Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203553

PFKM is regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet.… More details

$245 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PFKM, Recombinant Protein
Full Product Name
PFKM, 1-780aa, Human, His tag, E Coli
Product Gene Name
PFKM recombinant protein
Product Synonym Names
6-Phosphofructokinase muscle type; GSD7; PFK-1; PFK1; PFKA; PFKX; 6-Phosphofructokinase; muscle type 6 Phosphofructokinase Muscle Type; EC 2.7.1.11; MGC8699; PFKL; PFKM; PFKP; Phosphofructo 1 Kinase Isozyme A; Phosphofructokinase 1; Phosphofructokinase M; Phosphofructokinase; muscle; Phosphofructokinase; muscle type; Phosphofructokinase; polypeptide X; Phosphohexokinase.
Sequence
MGSSHHHHHH SSGLVPRGSH MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV
Host
E Coli
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 5mM DTT, 0.2 M NaCl, and 20% glycerol
Purity/Purification
> 80% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
87.3 kDa (800aa), confirmed by MALDI-TOF
3D Structure
ModBase 3D Structure for P08237
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for PFKM recombinant protein

Cancer
Applications Tested/Suitable for PFKM recombinant protein
SDS-PAGE

SDS-Page of PFKM recombinant protein

PFKM Recombinant Protein – Cat# MBS203553

Product References and Citations for PFKM recombinant protein

Martinez-Costa OH., et al. (2007) FEBS Lett. 581 (16):3033-8. ; Kim JW., et al. (2004) Mol Cell Biol. 24 (13):5923-36.;

Other Notes

Small volumes of PFKM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PFKM purchase

MBS203553 is a recombinant protein targeting PFKM. Also known as PFKM, 1-780aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PFKM. It may not necessarily be applicable to this product.

NCBI GI #
4505749
NCBI GeneID
5213
NCBI Accession #
NP_000280
UniProt Primary Accession #
P08237
UniProt Secondary Accession #
Q16814; Q16815; Q6ZTT1; J3KNX3
UniProt Related Accession #
P08237
GenBank Nucleotide #
NM_000289.5
NCBI Official Full Name
ATP-dependent 6-phosphofructokinase, muscle type isoform 2
NCBI Official Synonym Full Names
phosphofructokinase, muscle
NCBI Official Symbol
PFKM
NCBI Official Synonym Symbols
GSD7; PFK1; PFKA; PFKX; PFK-1; PFK-A; ATP-PFK; PPP1R122
UniProt Protein Name
ATP-dependent 6-phosphofructokinase, muscle type
UniProt Synonym Protein Names
6-phosphofructokinase type A; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphohexokinase
Protein Family
ATP-dependent 6-phosphofructokinase
UniProt Gene Name
PFKM
UniProt Synonym Gene Names
PFKX; ATP-PFK; PFK-M
NCBI Protein Information
ATP-dependent 6-phosphofructokinase, muscle type

NCBI Summary for PFKM

Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
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UniProt Comments for PFKM

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Research Articles on PFKM

1. Data indicate that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase3 (PFKFB3) and phosphofructokinase (PFK1) expression allows discrimination between induced pluripotent stem cells (iPS) and cancer stem cells (CSCs).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PFKM recombinant protein

 Reference Product  PubMed Publications
 PFKL recombinant protein  >9 publications with PFKM and PFKL
 HK2 recombinant protein  >6 publications with PFKM and HK2
 HK1 recombinant protein  >3 publications with PFKM and HK1
 PKM recombinant protein  >2 publications with PFKM and PKM
 PFKFB3 recombinant protein  >2 publications with PFKM and PFKFB3
 ALDOA recombinant protein  >2 publications with PFKM and ALDOA
 ALDOC recombinant protein  >1 publications with PFKM and ALDOC
 GPI recombinant protein  >1 publications with PFKM and GPI

Pathways associated with PFKM recombinant protein

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 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram

Diseases associated with PFKM recombinant protein

 Disease Name  Pubmed Publications
 Glycogen Storage Disease Type VII Antibodies  >6 publications with PFKM and Glycogen Storage Disease Type VII
 Liver Diseases Antibodies  >4 publications with PFKM and Liver Diseases
 Abnormalities, Multiple Antibodies  >4 publications with PFKM and Abnormalities, Multiple
 Anemia Antibodies  >4 publications with PFKM and Anemia
 Cardiovascular Diseases Antibodies  >2 publications with PFKM and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with PFKM and Hypertrophy
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with PFKM and Drug-Related Side Effects and Adverse Reactions
 Poisoning Antibodies  >2 publications with PFKM and Poisoning
 Breast Neoplasms Antibodies  >2 publications with PFKM and Breast Neoplasms
 Heart Diseases Antibodies  >2 publications with PFKM and Heart Diseases

Organs/Tissues associated with PFKM recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >45 publications with PFKM and Muscle
 Liver Antibodies  >12 publications with PFKM and Liver
 Blood Antibodies  >11 publications with PFKM and Blood
 Heart Antibodies  >6 publications with PFKM and Heart
 Brain Antibodies  >4 publications with PFKM and Brain
 Lung Antibodies  >3 publications with PFKM and Lung
 Eye Antibodies  >2 publications with PFKM and Eye
 Connective Tissue Antibodies  >2 publications with PFKM and Connective Tissue
 Testis Antibodies  >2 publications with PFKM and Testis
 Prostate Antibodies  >1 publications with PFKM and Prostate
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