TSTA3 Recombinant Protein

Name: TSTA3 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203588
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203588

TSTA3 is a NADP (H)-binding protein. It catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TSTA3, Recombinant Protein

Full Product Name

TSTA3, 1-321aa, Human, His tag, E Coli

Product Gene Name

TSTA3 recombinant protein

Product Synonym Names

GDP-L-fucose synthase; FX; P35B; SDR4E1; GDP-L-fucose synthase

Sequence

MGSSHHHHHH SSGLVPRGSH MGEPQGSMRI LVTGGSGLVG KAIQKVVADG AGLPGEDWVF VSSKDADLTD TAQTRALFEK VQPTHVIHLA AMVGGLFRNI KYNLDFWRKN VHMNDNVLHS AFEVGARKVV SCLSTCIFPD KTTYPIDETM IHNGPPHNSN FGYSYAKRMI DVQNRAYFQQ YGCTFTAVIP TNVFGPHDNF NIEDGHVLPG LIHKVHLAKS SGSALTVWGT GNPRRQFIYS LDLAQLFIWV LREYNEVEPI ILSVGEEDEV SIKEAAEAVV EAMDFHGEVT FDTTKSDGQF KKTASNSKLR TYLPDFRFTP FKQAVKETCA WFTDNYEQAR K

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 50mM NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

38.0 kDa (341aa) confirmed by MALDI-TOF

OMIM

U58766 mRNA

3D Structure

ModBase 3D Structure for Q13630

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for TSTA3 recombinant protein

Metabolism

Applications Tested/Suitable for TSTA3 recombinant protein

SDS-PAGE

Product References and Citations for TSTA3 recombinant protein

Camardella L., et al. (1995) Blood 85 (1): 264-7; Tonetti M., et al. (1996) J. Biol. Chem. 271:27274-27279;

Other Notes

Small volumes of TSTA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSTA3 purchase

MBS203588 is a recombinant protein targeting TSTA3. Also known as TSTA3, 1-321aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TSTA3. It may not necessarily be applicable to this product.

NCBI GI #

4507709

NCBI GeneID

7264

NCBI Accession #

NP_003304

UniProt Primary Accession #

Q13630

UniProt Secondary Accession #

Q567Q9; Q9UDG7; B2R8Y7; D3DWK5

UniProt Related Accession #

Q13630

GenBank Nucleotide #

NM_003313.3

NCBI Official Full Name

GDP-L-fucose synthase isoform 2

NCBI Official Synonym Full Names

tissue specific transplantation antigen P35B

NCBI Official Symbol

TSTA3

NCBI Official Synonym Symbols

FX; P35B; SDR4E1

UniProt Protein Name

GDP-L-fucose synthase

UniProt Synonym Protein Names

GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; Protein FX; Red cell NADP(H)-binding protein; Short-chain dehydrogenase/reductase family 4E member 1

UniProt Gene Name

TSTA3

UniProt Synonym Gene Names

SDR4E1

NCBI Protein Information

GDP-L-fucose synthase

NCBI Summary for TSTA3

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

UniProt Comments for TSTA3

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Research Articles on TSTA3

1. The findings suggest that miR-125a-5p/miR-125b suppress the expression of TSTA3, which controls cell proliferation and invasion by regulating CXCR4 expression. In conclusion, a high expression of TSTA3 exerts a proto-oncogenic effect during carcinogenesis and serves as an independent molecular marker for breast cancerpatients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TSTA3 recombinant protein

Reference Product	PubMed Publications
GMDS recombinant protein	>1 publications with TSTA3 and GMDS

Pathways associated with TSTA3 recombinant protein

Products by Pathway	Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies	Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
GDP-L-fucose Biosynthesis I (from GDP-D-mannose) Pathway antibodies	GDP-L-fucose Biosynthesis I (from GDP-D-mannose) Pathway Diagram
GDP-fucose Biosynthesis Pathway antibodies	GDP-fucose Biosynthesis Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram

Diseases associated with TSTA3 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>4 publications with TSTA3 and Inflammation
Liver Diseases Antibodies	>3 publications with TSTA3 and Liver Diseases
Anemia Antibodies	>2 publications with TSTA3 and Anemia
Breast Neoplasms Antibodies	>2 publications with TSTA3 and Breast Neoplasms
Nervous System Diseases Antibodies	>1 publications with TSTA3 and Nervous System Diseases
Ovarian Diseases Antibodies	>1 publications with TSTA3 and Ovarian Diseases
Diabetes Mellitus Antibodies	>1 publications with TSTA3 and Diabetes Mellitus
Atherosclerosis Antibodies	>1 publications with TSTA3 and Atherosclerosis
Cell Transformation, Neoplastic Antibodies	>1 publications with TSTA3 and Cell Transformation, Neoplastic
Fibrosis Antibodies	>1 publications with TSTA3 and Fibrosis

Organs/Tissues associated with TSTA3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>7 publications with TSTA3 and Blood
Liver Antibodies	>2 publications with TSTA3 and Liver
Vascular Antibodies	>1 publications with TSTA3 and Vascular
Heart Antibodies	>1 publications with TSTA3 and Heart
Bone Marrow Antibodies	>1 publications with TSTA3 and Bone Marrow
Bone Antibodies	>1 publications with TSTA3 and Bone
Muscle Antibodies	>1 publications with TSTA3 and Muscle
Eye Antibodies	>1 publications with TSTA3 and Eye
Parathyroid Antibodies	>1 publications with TSTA3 and Parathyroid
Lung Antibodies	>1 publications with TSTA3 and Lung