DHPS Recombinant Protein

Name: DHPS Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203593
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203593

DHPS, which belongs to the deoxyhypusine synthase family of proteins, is important for the first step in the hypusine biosynthesis pathway. This protein catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DHPS, Recombinant Protein

Full Product Name

DHPS, 1-369aa, Human, His tag, E Coli

Product Gene Name

DHPS recombinant protein

Product Synonym Names

Deoxyhypusine synthase; MIG13; Deoxyhypusine synthase DHS; DS; Migration inducing gene 13.

Sequence

MGSSHHHHHH SSGLVPRGSH MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG TTGFQATNFG RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF LGYTSNLISS GIRETIRYLV QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE FSLRGKELRE NGINRIGNLL VPNENYCKFE DWLMPILDQM VMEQNTEGVK WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS LGDMIFFHSY KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL VAETFAQKMD AFMHEKNED

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl

Purity/Purification

> 95% by SDS-PAGE

Concentration

1.0 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

43.1 kDa (389aa), confirmed by MALDI-TOF.

OMIM

L39068 mRNA

3D Structure

ModBase 3D Structure for P49366

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for DHPS recombinant protein

Enzymes & Proteases

Applications Tested/Suitable for DHPS recombinant protein

SDS-PAGE

Product References and Citations for DHPS recombinant protein

umland TC, et al. (2004) J. Biol. Chem. 279 (27): 28697-705; Jones T, et al. (1996) Genomics. 35 (3): 635-7.;

Other Notes

Small volumes of DHPS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DHPS purchase

MBS203593 is a recombinant protein targeting DHPS. Also known as DHPS, 1-369aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DHPS. It may not necessarily be applicable to this product.

NCBI GI #

4503325

NCBI GeneID

1725

NCBI Accession #

NP_001921

UniProt Primary Accession #

P49366

UniProt Secondary Accession #

Q13184; Q13276; Q9UDG0; A8K688; M0R1I5

UniProt Related Accession #

P49366

GenBank Nucleotide #

NM_001930.3

NCBI Official Full Name

deoxyhypusine synthase isoform a

NCBI Official Synonym Full Names

deoxyhypusine synthase

NCBI Official Symbol

DHPS

NCBI Official Synonym Symbols

DS; DHS; MIG13

UniProt Protein Name

Deoxyhypusine synthase

Protein Family

Dihydropteroate synthase

UniProt Gene Name

DHPS

UniProt Synonym Gene Names

DS; DHS

NCBI Protein Information

deoxyhypusine synthase

NCBI Summary for DHPS

This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

UniProt Comments for DHPS

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

Research Articles on DHPS

1. the use of N1-Guanyl-1,7-diaminoheptane, a DHPS inhibitor, resulted in a significant decrease in tumor formation in vivo. In patients with esophageal squamous cell carcinoma (ESCC), overexpression of DHPS in ESCC tumors was significantly associated with worse recurrence-free survival, and correlated with distant metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DHPS recombinant protein

Reference Product	PubMed Publications
DHFR recombinant protein	>326 publications with DHPS and DHFR
EIF5A recombinant protein	>7 publications with DHPS and EIF5A
DOHH recombinant protein	>4 publications with DHPS and DOHH
EIF5A2 recombinant protein	>3 publications with DHPS and EIF5A2

Pathways associated with DHPS recombinant protein

Products by Pathway	Pathway Diagram
Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies	Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
Hypusine Synthesis From EIF5A-lysine Pathway antibodies	Hypusine Synthesis From EIF5A-lysine Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Hypusine Biosynthesis Pathway antibodies	Hypusine Biosynthesis Pathway Diagram

Diseases associated with DHPS recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>21 publications with DHPS and Nervous System Diseases
Inflammation Antibodies	>17 publications with DHPS and Inflammation
Central Nervous System Diseases Antibodies	>17 publications with DHPS and Central Nervous System Diseases
Kidney Diseases Antibodies	>13 publications with DHPS and Kidney Diseases
Brain Diseases Antibodies	>13 publications with DHPS and Brain Diseases
Fibrosis Antibodies	>10 publications with DHPS and Fibrosis
Disease Models, Animal Antibodies	>7 publications with DHPS and Disease Models, Animal
Edema Antibodies	>7 publications with DHPS and Edema
Necrosis Antibodies	>6 publications with DHPS and Necrosis
Liver Diseases Antibodies	>5 publications with DHPS and Liver Diseases

Organs/Tissues associated with DHPS recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>133 publications with DHPS and Blood
Muscle Antibodies	>80 publications with DHPS and Muscle
Vascular Antibodies	>57 publications with DHPS and Vascular
Heart Antibodies	>52 publications with DHPS and Heart
Brain Antibodies	>45 publications with DHPS and Brain
Kidney Antibodies	>23 publications with DHPS and Kidney
Nerve Antibodies	>12 publications with DHPS and Nerve
Liver Antibodies	>12 publications with DHPS and Liver
Lung Antibodies	>10 publications with DHPS and Lung
Ganglia Antibodies	>6 publications with DHPS and Ganglia