FBP1 Recombinant Protein

Name: FBP1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203602
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203602

Fructose-1,6-bisphosphatase 1 (FBP1) is a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FBP1, Recombinant Protein

Full Product Name

FBP1, 1-338aa, Human, His tag, E Coli

Product Gene Name

FBP1 recombinant protein

Product Synonym Names

FBPase1; FBP; FBP1; D fructose 1 6 bisphosphate 1 phosphohydrolase 1; EC 3.1.3.11; FBP 1; FBPase 1; Fructose 1 6 bisphosphatase 1 Fructose bisphosphatase 1; Growth inhibiting protein 17; Liver fructose bisphosphatase.

Sequence

MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Molecular Weight

39.0 kDa (358aa), confirmed by MALDI-TOF.

OMIM

M19922 mRNA

3D Structure

ModBase 3D Structure for P09467

Antigen Species

Human

Tag Information

His-tag

Domain

1-338aa

Product Categories/Family for FBP1 recombinant protein

Metabolism

Applications Tested/Suitable for FBP1 recombinant protein

SDS-PAGE

Product References and Citations for FBP1 recombinant protein

Rabenhorst u., et al. (2009) Hepatology. 50 (4):1121-9. ; Hirota K., et al. (2008) Nature. 456 (7218):130-4.;

Other Notes

Small volumes of FBP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBP1 purchase

MBS203602 is a recombinant protein targeting FBP1. Also known as FBP1, 1-338aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FBP1. It may not necessarily be applicable to this product.

NCBI GI #

16579888

NCBI GeneID

2203

NCBI Accession #

NP_000498.2

UniProt Primary Accession #

P09467

UniProt Secondary Accession #

O75571; Q53F94; Q96E46

UniProt Related Accession #

P09467

GenBank Nucleotide #

NM_000507.3

NCBI Official Full Name

fructose-1,6-bisphosphatase 1

NCBI Official Synonym Full Names

fructose-bisphosphatase 1

NCBI Official Symbol

FBP1

NCBI Official Synonym Symbols

FBP

UniProt Protein Name

Fructose-1,6-bisphosphatase 1

UniProt Synonym Protein Names

D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase

Protein Family

Fat-body protein

UniProt Gene Name

FBP1

UniProt Synonym Gene Names

FBP; FBPase 1

NCBI Protein Information

fructose-1,6-bisphosphatase 1

NCBI Summary for FBP1

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

UniProt Comments for FBP1

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Research Articles on FBP1

1. Here, the first crystal structure of human liver FBPase in the R-state conformation is presented, determined at a resolution of 2.2 A in a tetragonal setting that exhibits an unusual arrangement of noncrystallographic symmetry (NCS) elements.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FBP1 recombinant protein

Reference Product	PubMed Publications
GPI recombinant protein	>8 publications with FBP1 and GPI
ALDOB recombinant protein	>4 publications with FBP1 and ALDOB
ALDOA recombinant protein	>3 publications with FBP1 and ALDOA
TKT recombinant protein	>2 publications with FBP1 and TKT
PFKP recombinant protein	>1 publications with FBP1 and PFKP
ALDOC recombinant protein	>1 publications with FBP1 and ALDOC
PFKL recombinant protein	>1 publications with FBP1 and PFKL

Pathways associated with FBP1 recombinant protein

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AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Angiopoietin Like Protein 8 Regulatory Pathway antibodies	Angiopoietin Like Protein 8 Regulatory Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Glucagon Signaling Pathway antibodies	Glucagon Signaling Pathway Diagram
Glucagon Signaling Pathway antibodies	Glucagon Signaling Pathway Diagram
Gluconeogenesis Pathway antibodies	Gluconeogenesis Pathway Diagram

Diseases associated with FBP1 recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>21 publications with FBP1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>13 publications with FBP1 and Carcinoma, Hepatocellular
Fructose-1,6-Diphosphatase Deficiency Antibodies	>12 publications with FBP1 and Fructose-1,6-Diphosphatase Deficiency
Liver Neoplasms Antibodies	>11 publications with FBP1 and Liver Neoplasms
Kidney Diseases Antibodies	>8 publications with FBP1 and Kidney Diseases
Inflammation Antibodies	>7 publications with FBP1 and Inflammation
Neoplasms, Experimental Antibodies	>6 publications with FBP1 and Neoplasms, Experimental
Lung Diseases Antibodies	>5 publications with FBP1 and Lung Diseases
Fatty Liver Antibodies	>5 publications with FBP1 and Fatty Liver
Hepatomegaly Antibodies	>4 publications with FBP1 and Hepatomegaly

Organs/Tissues associated with FBP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>40 publications with FBP1 and Liver
Blood Antibodies	>33 publications with FBP1 and Blood
Kidney Antibodies	>12 publications with FBP1 and Kidney
Lung Antibodies	>7 publications with FBP1 and Lung
Stomach Antibodies	>4 publications with FBP1 and Stomach
Bone Antibodies	>4 publications with FBP1 and Bone
Bone Marrow Antibodies	>3 publications with FBP1 and Bone Marrow
Intestine Antibodies	>3 publications with FBP1 and Intestine
Prostate Antibodies	>2 publications with FBP1 and Prostate
Pancreas Antibodies	>2 publications with FBP1 and Pancreas