Galectin-3 (LGALS3) Active Protein

Name: LGALS3 Active Protein; Galectin-3; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203603
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203603

Galectin-3 is a member of the family of animal lectins, which selectively binds beta-galactoside residues. This protein is secreted from cells by ectocytosis, which is independent of the classical secretory pathway through the endoplasmic reticulum/Golgi… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Galectin-3 (LGALS3), Active Protein

Full Product Name

Galectin-3, 1-250aa, Human, His tag, E Coli (Bioactivity Validated)

Product Gene Name

LGALS3 active protein

Product Synonym Names

CBP35; GAL3; GALBP; GALIG; LGALS2; MAC2.; 35 kDa lectin; Carbohydrate binding protein 35; Galactose-specific lectin 3; Galactoside-binding protein; Galectin 3 internal gene,included; Galectin-3; Galectin3; GBP; IgE binding protein; IgE-binding protein; L 31; L 34; L-34 galactoside-binding lectin; L31; LGALS3; Laminin-binding protein; Lectin L-29; MAC 2 antigen; Lectin; galactose binding; soluble 3; Mac-2; Macrophage galactose-specific lectin; MGC105387.

Sequence

MGSSHHHHHH SSGLVPRGSH MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI DLTSASYTMI

Host

E Coli

Form/Format

20 mM Tris-HCl Buffer, (pH 8.0), 10% glycerol, 1mM DTT, 0.1M NaCl

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

28.3 kDa (270aa), confirmed by MALDI-TOF.

OMIM

M57710 mRNA

3D Structure

ModBase 3D Structure for P17931

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Antigen Species

Human

Tag Information

His-tag

Biological Activity

The ED50 for this effect is less or equal to 15 ug/ml. Measured by its ability to agglutinate human red blood cells.

Product Categories/Family for LGALS3 active protein

Differentiation & Regeneration

Applications Tested/Suitable for LGALS3 active protein

SDS-PAGE

Product References and Citations for LGALS3 active protein

Barondes SH., et al. (1994) J Biol Chem. 269 (33):20807-10. ; Kadrofske MM., et al. (1998) Arch Biochem Biophys. 349 (1):7-20.

Other Notes

Small volumes of LGALS3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LGALS3 purchase

MBS203603 is an active protein targeting LGALS3. Also known as Galectin-3, 1-250aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LGALS3. It may not necessarily be applicable to this product.

NCBI GI #

115430223

NCBI GeneID

3958

NCBI Accession #

NP_002297

UniProt Primary Accession #

P17931

UniProt Secondary Accession #

Q16005; Q6IBA7; Q96J47; B2RC38

UniProt Related Accession #

P17931

GenBank Nucleotide #

NM_002306.3

NCBI Official Full Name

galectin-3 isoform 1

NCBI Official Synonym Full Names

galectin 3

NCBI Official Symbol

LGALS3

NCBI Official Synonym Symbols

L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2

UniProt Protein Name

Galectin-3

UniProt Synonym Protein Names

35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen

Protein Family

Galectin-3-binding protein

UniProt Gene Name

LGALS3

UniProt Synonym Gene Names

MAC2; Gal-3; CBP 35; GALBP

NCBI Protein Information

galectin-3

NCBI Summary for LGALS3

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

UniProt Comments for LGALS3

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Research Articles on LGALS3

1. Available experimental binding affinities for a small number of the tested compounds show very good agreement with the calculated energies and provide the rational approach for design of Gal-3 ligands with even higher affinity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LGALS3 active protein

Reference Product	PubMed Publications
LGALS3BP active protein	>56 publications with LGALS3 and LGALS3BP
MUC1 active protein	>36 publications with LGALS3 and MUC1
MMP2 active protein	>14 publications with LGALS3 and MMP2
BCL2 active protein	>12 publications with LGALS3 and BCL2
GEMIN4 active protein	>5 publications with LGALS3 and GEMIN4
NRAS active protein	>4 publications with LGALS3 and NRAS
HRAS active protein	>2 publications with LGALS3 and HRAS
DBI active protein	>1 publications with LGALS3 and DBI
SUFU active protein	>1 publications with LGALS3 and SUFU

Pathways associated with LGALS3 active protein

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies	Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies	Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Neutrophil Degranulation Pathway antibodies	Neutrophil Degranulation Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram

Diseases associated with LGALS3 active protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>638 publications with LGALS3 and Carcinoma
Inflammation Antibodies	>491 publications with LGALS3 and Inflammation
Fibrosis Antibodies	>369 publications with LGALS3 and Fibrosis
Adenocarcinoma Antibodies	>273 publications with LGALS3 and Adenocarcinoma
Disease Models, Animal Antibodies	>240 publications with LGALS3 and Disease Models, Animal
Neoplasm Metastasis Antibodies	>189 publications with LGALS3 and Neoplasm Metastasis
Adenoma Antibodies	>160 publications with LGALS3 and Adenoma
Breast Neoplasms Antibodies	>135 publications with LGALS3 and Breast Neoplasms
Necrosis Antibodies	>115 publications with LGALS3 and Necrosis
Liver Diseases Antibodies	>112 publications with LGALS3 and Liver Diseases

Organs/Tissues associated with LGALS3 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1000 publications with LGALS3 and Blood
Heart Antibodies	>488 publications with LGALS3 and Heart
Thyroid Antibodies	>357 publications with LGALS3 and Thyroid
Brain Antibodies	>287 publications with LGALS3 and Brain
Vascular Antibodies	>280 publications with LGALS3 and Vascular
Kidney Antibodies	>187 publications with LGALS3 and Kidney
Muscle Antibodies	>176 publications with LGALS3 and Muscle
Liver Antibodies	>174 publications with LGALS3 and Liver
Lung Antibodies	>173 publications with LGALS3 and Lung
Bone Antibodies	>149 publications with LGALS3 and Bone