PA2G4 Recombinant Protein

Name: PA2G4 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203652
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203652

PA2G4, also known as EBP1 (ErbB-3-binding protein 1), is a member of the peptidase M24C family and functions as an RNA-binding protein involved in cellular proliferation and differentiation processes. It is a component of pre-ribosomal ribonucleoprotein… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PA2G4, Recombinant Protein

Full Product Name

PA2G4, 1-394aa, Human, His tag, E Coli

Product Gene Name

PA2G4 recombinant protein

Product Synonym Names

Proliferation-associated protein 2G4; EBP1; HG4-1; p38-2G4; Proliferation-associated protein 2G4 38kDa; AA672939; Cell cycle protein p38 2G4 homolog; ErbB-3 binding protein 1; ErbB3 binding protein 1 ErbB3-binding protein Ebp1; hG4 1; IRES-specific cellular trans-acting factor 45 kDa; MGC81621; MGC94070; Mpp1.M545; p38 2G4; PA2G4; Plfap; Proliferation associated 2G4; zgc:86732; Proliferation associated 2G4; 38-KD; Proliferation-associated 2G4; 38kDa; Proliferation-associated 2G4; a; Proliferation-associated protein 1 Protein p38-2G4; si:dz150i12.2; wu:fb19b11; wu:ft56d05

Sequence

MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN VAHTFVVDVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS SASRKTQKKK KKKASKTAEN ATSGETLEEN EAGDLEHHHH HH

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol

Purity/Purification

> 95% by SDS-PAGE

Concentration

1.0 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

44.8kDa (402aa), confirmed by MALDI-TOF

OMIM

U59435 mRNA

3D Structure

ModBase 3D Structure for Q9UQ80

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for PA2G4 recombinant protein

Transcription & Translation

Applications Tested/Suitable for PA2G4 recombinant protein

SDS-PAGE

Product References and Citations for PA2G4 recombinant protein

Lamartine J. et al. (1997) Cytogenet Cell Genet. 78 (1):31-5; Yoo JY. et al. (2000) Br J Cancer. 82 (3):683-90.;

Other Notes

Small volumes of PA2G4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PA2G4 purchase

MBS203652 is a recombinant protein targeting PA2G4. Also known as PA2G4, 1-394aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PA2G4. It may not necessarily be applicable to this product.

NCBI GI #

124494254

NCBI GeneID

5036

NCBI Accession #

NP_006182

UniProt Primary Accession #

Q9UQ80

UniProt Secondary Accession #

O43846; Q9UM59

UniProt Related Accession #

Q9UQ80

GenBank Nucleotide #

NM_006191.2

NCBI Official Full Name

proliferation-associated protein 2G4

NCBI Official Synonym Full Names

proliferation-associated 2G4

NCBI Official Symbol

PA2G4

NCBI Official Synonym Symbols

EBP1; HG4-1; p38-2G4

UniProt Protein Name

Proliferation-associated protein 2G4

UniProt Synonym Protein Names

Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1

Protein Family

Proliferation-associated protein

UniProt Gene Name

PA2G4

UniProt Synonym Gene Names

EBP1; hG4-1

NCBI Protein Information

proliferation-associated protein 2G4

NCBI Summary for PA2G4

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for PA2G4

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation ().

Research Articles on PA2G4

1. The results demonstrate an important role of Ebp1 in promoting cell proliferation in Acute Myelogenous Leukemic Cells through the regulation of both rRNA synthesis and Proliferating Cell Nuclear Antigen expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PA2G4 recombinant protein

Products by Pathway	Pathway Diagram
Coregulation Of Androgen Receptor Activity Pathway antibodies	Coregulation Of Androgen Receptor Activity Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Neutrophil Degranulation Pathway antibodies	Neutrophil Degranulation Pathway Diagram

Diseases associated with PA2G4 recombinant protein

Disease Name	Pubmed Publications
Disease Progression Antibodies	>10 publications with PA2G4 and Disease Progression
Adenocarcinoma Antibodies	>8 publications with PA2G4 and Adenocarcinoma
Neoplasm Invasiveness Antibodies	>7 publications with PA2G4 and Neoplasm Invasiveness
Neoplasms, Experimental Antibodies	>4 publications with PA2G4 and Neoplasms, Experimental
Inflammation Antibodies	>4 publications with PA2G4 and Inflammation
Disease Models, Animal Antibodies	>4 publications with PA2G4 and Disease Models, Animal
Liver Diseases Antibodies	>3 publications with PA2G4 and Liver Diseases
Liver Neoplasms Antibodies	>3 publications with PA2G4 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>3 publications with PA2G4 and Carcinoma, Hepatocellular
Lung Diseases Antibodies	>3 publications with PA2G4 and Lung Diseases

Organs/Tissues associated with PA2G4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>15 publications with PA2G4 and Prostate
Blood Antibodies	>10 publications with PA2G4 and Blood
Muscle Antibodies	>5 publications with PA2G4 and Muscle
Liver Antibodies	>4 publications with PA2G4 and Liver
Salivary Gland Antibodies	>4 publications with PA2G4 and Salivary Gland
Mouth Antibodies	>4 publications with PA2G4 and Mouth
Lung Antibodies	>4 publications with PA2G4 and Lung
Brain Antibodies	>4 publications with PA2G4 and Brain
Embryonic Tissue Antibodies	>3 publications with PA2G4 and Embryonic Tissue
Kidney Antibodies	>2 publications with PA2G4 and Kidney