SNuPN Recombinant Protein

Name: SNuPN Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203669
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203669

SNuPN, also known as KPNBL or RNuT1, is a nuclear import adaptor protein belonging to the Snurportin family. Localizing to the cytoplasm and nucleus, Snurportin-1 contains an N-terminal IBB domain and a trimethylguanosine (m3G)-cap binding domain. It… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SNuPN, Recombinant Protein

Full Product Name

SNuPN, 1-360aa, Human, His tag, E Coli

Product Gene Name

SNuPN recombinant protein

Product Synonym Names

Snurportin1; KPNBL; RNuT1; Snurportin1; SPN1; Snurportin1

Sequence

MGSSHHHHHH SSGLVPRGSH MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.1M NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

1.0 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

43.3 (380aa) confirmed by MALDI-TOF

OMIM

AF039029 mRNA

3D Structure

ModBase 3D Structure for O95149

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for SNuPN recombinant protein

Adhesion & Movement

Applications Tested/Suitable for SNuPN recombinant protein

SDS-PAGE

Product References and Citations for SNuPN recombinant protein

Huber J., et al. (1998) EMBO J. 17 (14):4114-26.

Other Notes

Small volumes of SNuPN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNuPN purchase

Transcript factor proteins are classical examples of human proteins which reside in cytoplasm and require transporter 1 to move to DNA in the nucleus. SNuPN - human snurportin 1 - has emerged as a critical RNA transporter regulating gene and protein expression. Drugs compounds and vector virus screens have begun to unravel human mouse rat SNuPN (KPNBL rNUT1) functions. References and SNuPN gene information is found in PubMed ID searches. Determination of more information about possible pathways interactions products proteins for the RNA transporter 1 SNuPN will be aided with a HIS tag SNuPN recombinant human product. Our custom protein production service is considered #1. SNuPN recombinant protein is expressed in E coli mammalian cell free kit and purified by methods similar to other recombinant human proteins in MyBiosource services section of our catalog. Use our Creative Biomart produced protein recombinant to produce antibodies for ELISA assay today.

Additional Details

NCBI/Uniprot data below describe general gene information for SNuPN. It may not necessarily be applicable to this product.

NCBI GI #

110611151

NCBI GeneID

10073

NCBI Accession #

NP_001036053

UniProt Primary Accession #

O95149

UniProt Secondary Accession #

A6NE34; A8K0B0; D3DW76

UniProt Related Accession #

O95149

GenBank Nucleotide #

NM_001042588.1

NCBI Official Full Name

snurportin-1

NCBI Official Synonym Full Names

snurportin 1

NCBI Official Symbol

SNUPN

NCBI Official Synonym Symbols

KPNBL; RNUT1; Snurportin1

UniProt Protein Name

Snurportin-1

UniProt Synonym Protein Names

RNA U transporter 1

UniProt Gene Name

SNUPN

UniProt Synonym Gene Names

RNUT1; SPN1

NCBI Protein Information

snurportin-1

NCBI Summary for SNuPN

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for SNuPN

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Research Articles on SNuPN

1. Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SNuPN recombinant protein

Reference Product	PubMed Publications
XPO1 recombinant protein	>3 publications with SNuPN and XPO1
GEMIN2 recombinant protein	>1 publications with SNuPN and GEMIN2

Pathways associated with SNuPN recombinant protein

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Metabolism Of Non-coding RNA Pathway antibodies	Metabolism Of Non-coding RNA Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
SnRNP Assembly Pathway antibodies	SnRNP Assembly Pathway Diagram

Diseases associated with SNuPN recombinant protein

Disease Name	Pubmed Publications
Atrophy Antibodies	>3 publications with SNuPN and Atrophy
Lung Neoplasms Antibodies	>1 publications with SNuPN and Lung Neoplasms
Ovarian Diseases Antibodies	>1 publications with SNuPN and Ovarian Diseases

Organs/Tissues associated with SNuPN recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4 publications with SNuPN and Blood
Nerve Antibodies	>3 publications with SNuPN and Nerve
Brain Antibodies	>2 publications with SNuPN and Brain
Lung Antibodies	>1 publications with SNuPN and Lung