TP53I3 Recombinant Protein

Name: TP53I3 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203682
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203682

TP53I3, also known as quinone oxidoreductase PIG3, is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. It is localized to the cytoplasm and induced in primary, non-transformed and transformed… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TP53I3, Recombinant Protein

Full Product Name

TP53I3, 1-332aa, Human, His tag, E Coli

Product Gene Name

TP53I3 recombinant protein

Product Synonym Names

Quinone oxidoreductase PIG3; PIG3; Quinone oxidoreductase PIG3 p53 induced gene 3 protein; Putative quinone oxidoreductase; quinone oxidoreductase homolog; TP53I3; Tumor protein p53 inducible protein 3.

Sequence

MGSSHHHHHH SSGLVPRGSH MLAVHFDKPG GPENLYVKEV AKPSPGEGEV LLKVAASALN RADLMQRQGQ YDPPPGASNI LGLEASGHVA ELGPGCQGHW KIGDTAMALL PGGGQAQYVT VPEGLLMPIP EGLTLTQAAA IPEAWLTAFQ LLHLVGNVQA GDYVLIHAGL SGVGTAAIQL TRMAGAIPLV TAGSQKKLQM AEKLGAAAGF NYKKEDFSEA TLKFTKGAGV NLILDCIGGS YWEKNVNCLA LDGRWVLYGL MGGGDINGPL FSKLLFKRGS LITSLLRSRD NKYKQMLVNA FTEQILPHFS TEGPQRLLPV LDRIYPVTEI QEAHKYMEAN KNIGKIVLEL PQ

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

37.6 kDa (352aa), confirmed by MALDI-TOF

OMIM

AF010309 mRNA

3D Structure

ModBase 3D Structure for Q53FA7

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for TP53I3 recombinant protein

Cancer

Applications Tested/Suitable for TP53I3 recombinant protein

SDS-PAGE

Product References and Citations for TP53I3 recombinant protein

Flatt PM. et al. (2000) Cancer Lett. 156 (1):63-72.; Porte S, et al. (2009) J Biol Chem.. 284 (25):17194-205;

Other Notes

Small volumes of TP53I3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TP53I3 purchase

MBS203682 is a recombinant protein targeting TP53I3. Also known as TP53I3, 1-332aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TP53I3. It may not necessarily be applicable to this product.

NCBI GI #

22538446

NCBI GeneID

9540

NCBI Accession #

NP_671713

UniProt Primary Accession #

Q53FA7

UniProt Secondary Accession #

O14679; O14685; Q38G78; Q6JLE7; Q9BWB8; D6W533

UniProt Related Accession #

Q53FA7

GenBank Nucleotide #

NM_147184.3

NCBI Official Full Name

quinone oxidoreductase PIG3 isoform 1

NCBI Official Synonym Full Names

tumor protein p53 inducible protein 3

NCBI Official Symbol

TP53I3

NCBI Official Synonym Symbols

PIG3

UniProt Protein Name

Quinone oxidoreductase PIG3

UniProt Synonym Protein Names

Tumor protein p53-inducible protein 3; p53-induced gene 3 protein

Protein Family

Quinone oxidoreductase

UniProt Gene Name

TP53I3

UniProt Synonym Gene Names

PIG3

NCBI Protein Information

quinone oxidoreductase PIG3

NCBI Summary for TP53I3

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

UniProt Comments for TP53I3

May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).

Research Articles on TP53I3

1. Results revealed that PIG3 expression levels positively correlated with poor prognosis of non-small cell lung cancer (NSCLC) patients and indicate that PIG3 promotes NSCLC progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TP53I3 recombinant protein

Reference Product	PubMed Publications
TP53 recombinant protein	>14 publications with TP53I3 and TP53
TP63 recombinant protein	>1 publications with TP53I3 and TP63

Pathways associated with TP53I3 recombinant protein

Products by Pathway	Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
TP53 Regulates Transcription Of Cell Death Genes Pathway antibodies	TP53 Regulates Transcription Of Cell Death Genes Pathway Diagram
TP53 Regulates Transcription Of Several Additional Cell Death Genes Whose Specific Roles In P53-dependent Apoptosis Remain Uncertain Pathway antibodies	TP53 Regulates Transcription Of Several Additional Cell Death Genes Whose Specific Roles In P53-dependent Apoptosis Remain Uncertain Pathway Diagram
Transcriptional Regulation By TP53 Pathway antibodies	Transcriptional Regulation By TP53 Pathway Diagram
P53 Signaling Pathway antibodies	P53 Signaling Pathway Diagram
P53 Signaling Pathway antibodies	P53 Signaling Pathway Diagram

Diseases associated with TP53I3 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>15 publications with TP53I3 and Carcinoma
Lung Neoplasms Antibodies	>7 publications with TP53I3 and Lung Neoplasms
Breast Neoplasms Antibodies	>5 publications with TP53I3 and Breast Neoplasms
Adenocarcinoma Antibodies	>4 publications with TP53I3 and Adenocarcinoma
Cell Transformation, Neoplastic Antibodies	>3 publications with TP53I3 and Cell Transformation, Neoplastic
Carcinoma, Hepatocellular Antibodies	>3 publications with TP53I3 and Carcinoma, Hepatocellular
Carcinoma, Squamous Cell Antibodies	>2 publications with TP53I3 and Carcinoma, Squamous Cell
Colonic Neoplasms Antibodies	>2 publications with TP53I3 and Colonic Neoplasms
Nervous System Diseases Antibodies	>1 publications with TP53I3 and Nervous System Diseases
Liver Diseases Antibodies	>1 publications with TP53I3 and Liver Diseases

Organs/Tissues associated with TP53I3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>7 publications with TP53I3 and Lung
Blood Antibodies	>3 publications with TP53I3 and Blood
Liver Antibodies	>3 publications with TP53I3 and Liver
Bone Antibodies	>3 publications with TP53I3 and Bone
Stomach Antibodies	>2 publications with TP53I3 and Stomach
Skin Antibodies	>2 publications with TP53I3 and Skin
Vascular Antibodies	>2 publications with TP53I3 and Vascular
Brain Antibodies	>2 publications with TP53I3 and Brain
Nerve Antibodies	>1 publications with TP53I3 and Nerve
Kidney Antibodies	>1 publications with TP53I3 and Kidney