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14-3-3 sigma Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Popular Catalog #: MBS203684

14-3-3 sigma,also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and… More details

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Product Overview

Online Datasheet in PDF
Product Name
14-3-3 sigma, Recombinant Protein
Full Product Name
14-3-3 sigma, 1-248aa, Human, E Coli
Product Gene Name
14-3-3 sigma recombinant protein
Product Synonym Names
stratifin; Epithelial cell marker protein 1; HME1; YWHAS; SFN; 14-3-3 sigma
Sequence
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 50mM NaCl, 10% glycerol
Purity/Purification
> 95% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
27.7 kDa (248aa), confirmed by MALDI-TOF.
OMIM
M93010 mRNA
3D Structure
ModBase 3D Structure for P31947
Antigen Species
Human
Tag
Non-tagged

Product Categories/Family for 14-3-3 sigma recombinant protein

Apoptosis

SDS-Page of 14-3-3 sigma recombinant protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
14-3-3 sigma Recombinant Protein – Cat# MBS203684

Product References and Citations for 14-3-3 sigma recombinant protein

Benzinger A., et al. (2005) Mol Cell Proteomics. 4 (6): 785-95.; Wilker E W., et al. (2005) J Biol Chem. 280:18891-18898.;

Other Notes

Small volumes of 14-3-3 sigma recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 14-3-3 sigma purchase

MBS203684 is a recombinant protein targeting 14-3-3 sigma. Also known as 14-3-3 sigma, 1-248aa, Human, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for 14-3-3 sigma. It may not necessarily be applicable to this product.

NCBI GI #
5454052
NCBI GeneID
2810
NCBI Accession #
NP_006133
UniProt Primary Accession #
P31947
UniProt Secondary Accession #
Q6FH30; Q6FH51; Q96DH0
UniProt Related Accession #
P31947
GenBank Nucleotide #
NM_006142.4
NCBI Official Full Name
14-3-3 protein sigma
NCBI Official Synonym Full Names
stratifin
NCBI Official Symbol
SFN
NCBI Official Synonym Symbols
YWHAS
UniProt Protein Name
14-3-3 protein sigma
UniProt Synonym Protein Names
Epithelial cell marker protein 1; Stratifin
Protein Family
14-3-3 protein
UniProt Gene Name
SFN
UniProt Synonym Gene Names
HME1
NCBI Protein Information
14-3-3 protein sigma

NCBI Summary for 14-3-3 sigma

This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]

UniProt Comments for 14-3-3 sigma

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
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Research Articles on 14-3-3 sigma

1. 14-3-3sigma has a paracrine effect in educating stromal cells in tumor-associated microenvironment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with 14-3-3 sigma recombinant protein

 Reference Product  PubMed Publications
 TP53 recombinant protein  >19 publications with 14-3-3 sigma and TP53
 CDC25C recombinant protein  >6 publications with 14-3-3 sigma and CDC25C
 AKT1 recombinant protein  >4 publications with 14-3-3 sigma and AKT1
 YWHAZ recombinant protein  >4 publications with 14-3-3 sigma and YWHAZ
 CDC25B recombinant protein  >2 publications with 14-3-3 sigma and CDC25B
 TSC2 recombinant protein  >1 publications with 14-3-3 sigma and TSC2
 CBY1 recombinant protein  >1 publications with 14-3-3 sigma and CBY1

Pathways associated with 14-3-3 sigma recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with 14-3-3 sigma recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >231 publications with 14-3-3 sigma and Carcinoma
 Nervous System Diseases Antibodies  >145 publications with 14-3-3 sigma and Nervous System Diseases
 Adenocarcinoma Antibodies  >111 publications with 14-3-3 sigma and Adenocarcinoma
 Breast Neoplasms Antibodies  >101 publications with 14-3-3 sigma and Breast Neoplasms
 Inflammation Antibodies  >98 publications with 14-3-3 sigma and Inflammation
 Disease Models, Animal Antibodies  >75 publications with 14-3-3 sigma and Disease Models, Animal
 Necrosis Antibodies  >70 publications with 14-3-3 sigma and Necrosis
 Cardiovascular Diseases Antibodies  >69 publications with 14-3-3 sigma and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >46 publications with 14-3-3 sigma and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >44 publications with 14-3-3 sigma and Neoplasm Metastasis

Organs/Tissues associated with 14-3-3 sigma recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >169 publications with 14-3-3 sigma and Skin
 Blood Antibodies  >146 publications with 14-3-3 sigma and Blood
 Nerve Antibodies  >128 publications with 14-3-3 sigma and Nerve
 Lung Antibodies  >87 publications with 14-3-3 sigma and Lung
 Brain Antibodies  >81 publications with 14-3-3 sigma and Brain
 Thyroid Antibodies  >79 publications with 14-3-3 sigma and Thyroid
 Prostate Antibodies  >77 publications with 14-3-3 sigma and Prostate
 Liver Antibodies  >77 publications with 14-3-3 sigma and Liver
 Muscle Antibodies  >49 publications with 14-3-3 sigma and Muscle
 Heart Antibodies  >32 publications with 14-3-3 sigma and Heart
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