HSD17B10 Recombinant Protein

Name: HSD17B10 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203699
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203699

HSD17B10 is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. HSD17B10 plays an important role in processing steroid hormones and fats,… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HSD17B10, Recombinant Protein

Full Product Name

HSD17B10, 12-261aa, Human, His tag, E Coli

Product Gene Name

HSD17B10 recombinant protein

Product Synonym Names

3-hydroxyacyl-CoA dehydrogenase type-2; Hydroxyacyl Coenzyme A dehydrogenase type II; Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase; 17 beta hydroxysteroid dehydrogenase 10; 17 beta hydroxysteroid dehydrogenase type 10; 17b HSD10; 3 hydroxy 2 methylbutyryl CoA dehydrogenase; 3 hydroxyacyl CoA dehydrogenase type 2; 3 hydroxyacyl CoA dehydrogenase type II; AB binding alcohol dehydrogenase; ABAD; Ads9; Amyloid beta binding polypeptide; Amyloid beta peptide binding alcohol dehydrogenase; Amyloid beta peptide binding protein; CAMR; DuPXp11.22; Endoplasmic Reticulum Amyloid Binding Protein; Endoplasmic reticulum associated amyloid beta peptide binding protein; ER associated amyloid beta-binding protein; ERAB; HADH 2; HADH2; HCD 2; HCD2; HSD17B10; Hydroxyacyl CoA Dehydrogenase type II; Hydroxysteroid (17 beta) dehydrogenase 10; Mental retardation X linked syndromic 11; MHBD; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; MRPP2; MRX17; SCHAD; SDR5C1; Short chain dehydrogenase/reductase family 5C member 1; Short chain L 3 hydroxyacyl CoA dehydrogenase type 2; Short chain type dehydrogenase/reductase XH98G2; Type 10 17b HSD; Type 10 17beta hydroxysteroid dehydrogenase; Type II HADH; XH98G2; 3-hydroxyacyl-CoA dehydrogenase type-2

Sequence

MGSSHHHHHH SSGLVPRGSH MVAVITGGAS GLGLATAERL VGQGASAVLL DLPNSGGEAQ AKKLGNNCVF APADVTSEKD VQTALALAKG KFGRVDVAVN CAGIAVASKT YNLKKGQTHT LEDFQRVLDV NLMGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL PIARDLAPIG IRVMTIAPGL FGTPLLTSLP EKVCNFLASQ VPFPSRLGDP AEYAHLVQAI IENPFLNGEV IRLDGAIRMQ P

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 1mM DTT, and 100 mM NaCl.

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

28.1 kDa (271aa), confirmed by MALDI-TOF.

OMIM

U96132 mRNA

3D Structure

ModBase 3D Structure for Q99714

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for HSD17B10 recombinant protein

Redox Proteins

Applications Tested/Suitable for HSD17B10 recombinant protein

SDS-PAGE

Product References and Citations for HSD17B10 recombinant protein

Hoizmann J., et al. (2008) Cell. 135 (3):462-74. ; Yan SD., et al. (1997) Nature. 389 (6652):689-95. ;

Other Notes

Small volumes of HSD17B10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSD17B10 purchase

MBS203699 is a recombinant protein targeting HSD17B10. Also known as HSD17B10, 12-261aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD17B10. It may not necessarily be applicable to this product.

NCBI GI #

4758504

NCBI GeneID

3028

NCBI Accession #

NP_004484

UniProt Primary Accession #

Q99714

UniProt Secondary Accession #

Q5H927; Q6IBS9; Q8TCV9; Q96HD5

UniProt Related Accession #

Q99714

GenBank Nucleotide #

NM_004493.2

NCBI Official Full Name

3-hydroxyacyl-CoA dehydrogenase type-2 isoform 1

NCBI Official Synonym Full Names

hydroxysteroid 17-beta dehydrogenase 10

NCBI Official Symbol

HSD17B10

NCBI Official Synonym Symbols

ABAD; CAMR; ERAB; HCD2; MHBD; HADH2; MRPP2; MRX17; MRX31; SCHAD; MRXS10; SDR5C1; HSD10MD; 17b-HSD10; DUPXp11.22

UniProt Protein Name

3-hydroxyacyl-CoA dehydrogenase type-2

UniProt Synonym Protein Names

17-beta-hydroxysteroid dehydrogenase 10 (EC:1.1.1.51

Protein Family

3-hydroxyacyl-CoA dehydrogenase

UniProt Gene Name

HSD17B10

UniProt Synonym Gene Names

ERAB; HADH2; MRPP2; SCHAD; SDR5C1; XH98G2; Mitochondrial RNase P protein 2

NCBI Protein Information

3-hydroxyacyl-CoA dehydrogenase type-2

NCBI Summary for HSD17B10

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

UniProt Comments for HSD17B10

Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426).

Research Articles on HSD17B10

1. in addition to being an essential component of the RNase P reaction, MRPP1/2 serves as a processing platform for several down-stream tRNA maturation steps in human mitochondria.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HSD17B10 recombinant protein

Reference Product	PubMed Publications
TRMT10C recombinant protein	>7 publications with HSD17B10 and TRMT10C
ACAT1 recombinant protein	>2 publications with HSD17B10 and ACAT1
ACAT2 recombinant protein	>1 publications with HSD17B10 and ACAT2
ECHS1 recombinant protein	>1 publications with HSD17B10 and ECHS1

Pathways associated with HSD17B10 recombinant protein

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimers Disease Pathway antibodies	Alzheimers Disease Pathway Diagram
Branched-chain Amino Acid Catabolism Pathway antibodies	Branched-chain Amino Acid Catabolism Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
L-isoleucine Degradation I Pathway antibodies	L-isoleucine Degradation I Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Tryptophan Metabolism Pathway antibodies	Tryptophan Metabolism Pathway Diagram

Diseases associated with HSD17B10 recombinant protein

Disease Name	Pubmed Publications
Neurobehavioral Manifestations Antibodies	>14 publications with HSD17B10 and Neurobehavioral Manifestations
Disease Models, Animal Antibodies	>7 publications with HSD17B10 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>5 publications with HSD17B10 and Cardiovascular Diseases
Mental Retardation, X-Linked, Syndromic 10 Antibodies	>5 publications with HSD17B10 and Mental Retardation, X-Linked, Syndromic 10
Liver Diseases Antibodies	>3 publications with HSD17B10 and Liver Diseases
Fatty Liver Antibodies	>3 publications with HSD17B10 and Fatty Liver
Heart Diseases Antibodies	>3 publications with HSD17B10 and Heart Diseases
Dyslipidemias Antibodies	>2 publications with HSD17B10 and Dyslipidemias
Neoplasms, Experimental Antibodies	>2 publications with HSD17B10 and Neoplasms, Experimental
Abnormalities, Multiple Antibodies	>2 publications with HSD17B10 and Abnormalities, Multiple

Organs/Tissues associated with HSD17B10 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>33 publications with HSD17B10 and Brain
Blood Antibodies	>9 publications with HSD17B10 and Blood
Prostate Antibodies	>8 publications with HSD17B10 and Prostate
Muscle Antibodies	>7 publications with HSD17B10 and Muscle
Liver Antibodies	>7 publications with HSD17B10 and Liver
Heart Antibodies	>4 publications with HSD17B10 and Heart
Testis Antibodies	>3 publications with HSD17B10 and Testis
Nerve Antibodies	>3 publications with HSD17B10 and Nerve
Vascular Antibodies	>3 publications with HSD17B10 and Vascular
Bone Antibodies	>3 publications with HSD17B10 and Bone