DNAJB11 Recombinant Protein

Name: DNAJB11 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203750
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203750

DNAJB11 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. It serves as a co-chaperone for HSPA5 and binds directly to both unfolded proteins that are substrates… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DNAJB11, Recombinant Protein

Full Product Name

DNAJB11, 23-358aa, Human, His tag, E Coli

Product Gene Name

DNAJB11 recombinant protein

Product Synonym Names

DnaJ homolog subfamily B member 11; ABBP-2; ABBP2; DJ9; EDJ; ERdj3; ERj3; hDj9; HEDJ; PRO1080; uNQ537

Sequence

MGSSHHHHHH SSGLVPRGSH MGRDFYKILG VPRSASIKDI KKAYRKLALQ LHPDRNPDDP QAQEKFQDLG AAYEVLSDSE KRKQYDTYGE EGLKDGHQSS HGDIFSHFFG DFGFMFGGTP RQQDRNIPRG SDIIVDLEVT LEEVYAGNFV EVVRNKPVAR QAPGKRKCNC RQEMRTTQLG PGRFQMTQEV VCDECPNVKL VNEERTLEVE IEPGVRDGME YPFIGEGEPH VDGEPGDLRF RIKVVKHPIF ERRGDDLYTN VTISLVESLV GFEMDITHLD GHKVHISRDK ITRPGAKLWK KGEGLPNFDN NNIKGSLIIT FDVDFPKEQL TEEAREGIKQ LLKQGSVQKV YNGLQGY

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

40.5 kDa (357aa), confirmed by MALDI-TOF

OMIM

AB028859 mRNA

3D Structure

ModBase 3D Structure for Q9UBS4

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for DNAJB11 recombinant protein

Heat Shock Proteins

Applications Tested/Suitable for DNAJB11 recombinant protein

SDS-PAGE

Product References and Citations for DNAJB11 recombinant protein

Nakanishi K., et al. (2004) Cell Stress Chaperones. 9 (3):253-64. ; Yu M., et al. (2000) J Biol Chem. 275 (32):24984-92.

Other Notes

Small volumes of DNAJB11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNAJB11 purchase

MBS203750 is a recombinant protein targeting DNAJB11. Also known as DNAJB11, 23-358aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAJB11. It may not necessarily be applicable to this product.

NCBI GI #

7706495

NCBI GeneID

51726

NCBI Accession #

NP_057390

UniProt Primary Accession #

Q9UBS4

UniProt Secondary Accession #

Q542Y5; Q542Y9; Q6IAQ8; Q96JC6

UniProt Related Accession #

Q9UBS4

GenBank Nucleotide #

NM_016306.5

NCBI Official Full Name

dnaJ homolog subfamily B member 11

NCBI Official Synonym Full Names

DnaJ heat shock protein family (Hsp40) member B11

NCBI Official Symbol

DNAJB11

NCBI Official Synonym Symbols

DJ9; EDJ; Dj-9; ERj3; ABBP2; ERdj3; ERj3p; ABBP-2; UNQ537; PRO1080

UniProt Protein Name

DnaJ homolog subfamily B member 11

UniProt Synonym Protein Names

APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; Endoplasmic reticulum DNA J domain-containing protein 3; ER-resident protein ERdj3; ERdj3; ERj3p; HEDJ; Human DnaJ protein 9; hDj-9; PWP1-interacting protein 4

Protein Family

DnaJ homolog subfamily

UniProt Gene Name

DNAJB11

UniProt Synonym Gene Names

EDJ; ERJ3; HDJ9; ABBP-2; ER-resident protein ERdj3; ERdj3; ERj3p; hDj-9

NCBI Protein Information

dnaJ homolog subfamily B member 11

NCBI Summary for DNAJB11

This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]

UniProt Comments for DNAJB11

Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.

Research Articles on DNAJB11

1. ZAAT ER clearance resulted from enhancing ERdj3-mediated ZAAT degradation by silencing ERdj3 while simultaneously enhancing autophagy. In this context, ERdj3 suppression may eliminate the toxic gain of function associated with polymerization of ZAAT

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DNAJB11 recombinant protein

Reference Product	PubMed Publications
DNAJC3 recombinant protein	>4 publications with DNAJB11 and DNAJC3
SDF2L1 recombinant protein	>2 publications with DNAJB11 and SDF2L1

Pathways associated with DNAJB11 recombinant protein

Products by Pathway	Pathway Diagram
IRE1alpha Activates Chaperones Pathway antibodies	IRE1alpha Activates Chaperones Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Photodynamic Therapy-induced Unfolded Protein Response Pathway antibodies	Photodynamic Therapy-induced Unfolded Protein Response Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Unfolded Protein Response (UPR) Pathway antibodies	Unfolded Protein Response (UPR) Pathway Diagram
XBP1(S) Activates Chaperone Genes Pathway antibodies	XBP1(S) Activates Chaperone Genes Pathway Diagram

Diseases associated with DNAJB11 recombinant protein

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>1 publications with DNAJB11 and Insulin Resistance

Organs/Tissues associated with DNAJB11 recombinant protein

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>4 publications with DNAJB11 and Pancreas
Kidney Antibodies	>1 publications with DNAJB11 and Kidney
Muscle Antibodies	>1 publications with DNAJB11 and Muscle
Ovary Antibodies	>1 publications with DNAJB11 and Ovary
Mouth Antibodies	>1 publications with DNAJB11 and Mouth
Blood Antibodies	>1 publications with DNAJB11 and Blood
Liver Antibodies	>1 publications with DNAJB11 and Liver
Stomach Antibodies	>1 publications with DNAJB11 and Stomach
Placenta Antibodies	>1 publications with DNAJB11 and Placenta