NuDT2 Recombinant Protein

Name: NuDT2 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203765
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203765

NuDT2 is a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NuDIX hydrolase family. This protein maintains homeostasis by using water to cleave the metabolite NuDT symmetrically back into its original ATP and AMP molecules.… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NuDT2, Recombinant Protein

Full Product Name

NuDT2, 1-147aa, Human, His tag, E Coli

Product Gene Name

NuDT2 recombinant protein

Product Synonym Names

bis (5'-nucleosyl)-tetraphosphatase [asymmetrical]; APAH1; MGC10404

Sequence

MGSSHHHHHH SSGLVPRGSH MALRACGLII FRRCLIPKVD NNAIEFLLLQ ASDGIHHWTP PKGHVEPGED DLETALRETQ EEAGIEAGQL TIIEGFKREL NYVARNKPKT VIYWLAEVKD YDVEIRLSHE HQAYRWLGLE EACQLAQFKE MKAALQEGHQ FLCSIEA

Host

E Coli

Form/Format

Liquid. In 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

19.0 kDa (167aa), confirmed by MALDI-TOF

OMIM

U30313 mRNA

3D Structure

ModBase 3D Structure for P50583

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for NuDT2 recombinant protein

Enzymes & Proteases

Applications Tested/Suitable for NuDT2 recombinant protein

SDS-PAGE

Product References and Citations for NuDT2 recombinant protein

Swarbrick JD., et al. (2005) J Biol Chem. 280 (9):8471-81.

Other Notes

Small volumes of NuDT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NuDT2 purchase

MBS203765 is a recombinant protein targeting NuDT2. Also known as NuDT2, 1-147aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NuDT2. It may not necessarily be applicable to this product.

NCBI GI #

22219467

NCBI GeneID

318

NCBI Accession #

NP_671702

UniProt Primary Accession #

P50583

UniProt Secondary Accession #

Q5T589; D3DRM0

UniProt Related Accession #

P50583

GenBank Nucleotide #

NM_147173.2

NCBI Official Full Name

NUDT2 gene product

NCBI Official Synonym Full Names

nudix hydrolase 2

NCBI Official Symbol

NUDT2

NCBI Official Synonym Symbols

APAH1

UniProt Protein Name

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

UniProt Synonym Protein Names

Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Ap4A hydrolase; Ap4Aase; Diadenosine tetraphosphatase; Nucleoside diphosphate-linked moiety X motif 2; Nudix motif 2

Protein Family

Nudix hydrolase

UniProt Gene Name

NUDT2

UniProt Synonym Gene Names

APAH1; Ap4A hydrolase; Ap4Aase; Diadenosine tetraphosphatase; Nudix motif 2

NCBI Protein Information

bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

NCBI Summary for NuDT2

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

UniProt Comments for NuDT2

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

Research Articles on NuDT2

1. NUDT2 is a novel complex formation enhancing factor regulating mTORC1-Rag GTPase signaling that is crucial for cell growth control.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NuDT2 recombinant protein

Products by Pathway	Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram

Diseases associated with NuDT2 recombinant protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>2 publications with NuDT2 and Breast Neoplasms
Neoplasm Metastasis Antibodies	>1 publications with NuDT2 and Neoplasm Metastasis
Neoplasm Invasiveness Antibodies	>1 publications with NuDT2 and Neoplasm Invasiveness
Adenocarcinoma Antibodies	>1 publications with NuDT2 and Adenocarcinoma
Inflammation Antibodies	>1 publications with NuDT2 and Inflammation