MAPKSP1 Recombinant Protein

Name: MAPKSP1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203768
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203768

MAPKSP1 (Mitogen-activated protein kinase scaffold protein 1) is a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAPKSP1, Recombinant Protein

Full Product Name

MAPKSP1, 1-124aa, Human, His tag, E Coli

Product Gene Name

MAPKSP1 recombinant protein

Product Synonym Names

Mitogen-activated protein kinase scaffold protein 1; MAP2K1IP1; MAPBP; MP1

Sequence

MGSSHHHHHH SSGLVPRGSH MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDNA PEHALRPGFL STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT GLIVSLEKEL APLFEELRQV VEVS

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 5mM DTT, 100mM NaCl

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

15.8kDa (144aa) confirmed by MALDI-TOF

OMIM

AF201947 mRNA

3D Structure

ModBase 3D Structure for Q9UHA4

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for MAPKSP1 recombinant protein

Signal Transduction

Applications Tested/Suitable for MAPKSP1 recombinant protein

SDS-PAGE

Product References and Citations for MAPKSP1 recombinant protein

Wunderlich, et al. (2001) J. Cell Biol. (united States) 152 (4): 765-76.; Schaeffer HJ, et al. (1998) Science 281 (5383): 1668-71.

Other Notes

Small volumes of MAPKSP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAPKSP1 purchase

MBS203768 is a recombinant protein targeting MAPKSP1. Also known as MAPKSP1, 1-124aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MAPKSP1. It may not necessarily be applicable to this product.

NCBI GI #

11496277

NCBI GeneID

8649

NCBI Accession #

NP_068805

UniProt Primary Accession #

Q9UHA4

UniProt Secondary Accession #

Q9H364; B2R4A1; J3KMX4

UniProt Related Accession #

Q9UHA4

GenBank Nucleotide #

NM_021970.3

NCBI Official Full Name

ragulator complex protein LAMTOR3 isoform 1

NCBI Official Synonym Full Names

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

NCBI Official Symbol

LAMTOR3

NCBI Official Synonym Symbols

MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3

UniProt Protein Name

Ragulator complex protein LAMTOR3

UniProt Synonym Protein Names

Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MEK-binding partner 1; Mp1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1

UniProt Gene Name

LAMTOR3

UniProt Synonym Gene Names

MAP2K1IP1; MAPKSP1; Mp1

NCBI Protein Information

ragulator complex protein LAMTOR3

NCBI Summary for MAPKSP1

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

UniProt Comments for MAPKSP1

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Research Articles on MAPKSP1

1. BCL2 expression in mesennchymal lung cancer cells was induced by ERK1 activity through the upregulation of the MEK1/ERK1 scaffold protein MEK partner-1. Interfering with the MEK1/MP1/ERK1 axis using a MEK1 inhibitor or MP1 depletion repressed BCL2 expression and sensitized MLCCs to chemoradiotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MAPKSP1 recombinant protein

Reference Product	PubMed Publications
LAMTOR2 recombinant protein	>12 publications with MAPKSP1 and LAMTOR2
LAMTOR1 recombinant protein	>4 publications with MAPKSP1 and LAMTOR1
LAMTOR4 recombinant protein	>3 publications with MAPKSP1 and LAMTOR4
MAP2K1 recombinant protein	>3 publications with MAPKSP1 and MAP2K1
MAPK1 recombinant protein	>1 publications with MAPKSP1 and MAPK1

Pathways associated with MAPKSP1 recombinant protein

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies	Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
FCERI Mediated MAPK Activation Pathway antibodies	FCERI Mediated MAPK Activation Pathway Diagram

Diseases associated with MAPKSP1 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>1 publications with MAPKSP1 and Inflammation

Organs/Tissues associated with MAPKSP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Stomach Antibodies	>2 publications with MAPKSP1 and Stomach
Skin Antibodies	>2 publications with MAPKSP1 and Skin
Brain Antibodies	>2 publications with MAPKSP1 and Brain
Lymph Node Antibodies	>1 publications with MAPKSP1 and Lymph Node
Blood Antibodies	>1 publications with MAPKSP1 and Blood
Muscle Antibodies	>1 publications with MAPKSP1 and Muscle
Embryonic Tissue Antibodies	>1 publications with MAPKSP1 and Embryonic Tissue
Lung Antibodies	>1 publications with MAPKSP1 and Lung