CIB2 Recombinant Protein

Name: CIB2 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203779
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203779

CIB2 belongs to calcium and integrin-binding family. CIB2 may be a Ca2+-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In skeletal muscle, CIB2 colocalizes with the integrin alpha7B subunit at the… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CIB2, Recombinant Protein

Full Product Name

CIB2, 1-187aa, Human, His tag, E Coli

Product Gene Name

CIB2 recombinant protein

Product Synonym Names

calcium and integrin binding family member 2; KIP2

Sequence

MGSSHHHHHH SSGLVPRGSH MGNKQTIFTE EQLDNYQDCT FFNKKDILKL HSRFYELAPN LVPMDYRKSP IVHVPMSLII QMPELRENPF KERIVAAFSE DGEGNLTFND FVDMFSVLCE SAPRELKANY AFKIYDFNTD NFICKEDLEL TLARLTKSEL DEEEVVLVCD KVIEEADLDG DGKLGFADFE DMIAKAPDFL STFHIRI

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 100mM NaCl, 1mM PMSF

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

23.8kDa (207aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

OMIM

AB012955 mRNA

3D Structure

ModBase 3D Structure for O75838

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for CIB2 recombinant protein

Signal Transduction

Applications Tested/Suitable for CIB2 recombinant protein

SDS-PAGE

Product References and Citations for CIB2 recombinant protein

Yu Y., et al. (2009) Mol Biol Rep. 36 (7):1799-809.; Hager M., et al. (2008) J Biol Chem. 5;283 (36):24760-9.

Other Notes

Small volumes of CIB2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CIB2 purchase

MBS203779 is a recombinant protein targeting CIB2. Also known as CIB2, 1-187aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CIB2. It may not necessarily be applicable to this product.

NCBI GI #

5453708

NCBI GeneID

10518

NCBI Accession #

NP_006374

UniProt Primary Accession #

O75838

UniProt Secondary Accession #

Q05BT6; B4DDF0; H0YM71

UniProt Related Accession #

O75838

GenBank Nucleotide #

NM_006383.3

NCBI Official Full Name

calcium and integrin-binding family member 2 isoform 1

NCBI Official Synonym Full Names

calcium and integrin binding family member 2

NCBI Official Symbol

CIB2

NCBI Official Synonym Symbols

KIP2; USH1J; DFNB48

UniProt Protein Name

Calcium and integrin-binding family member 2

UniProt Synonym Protein Names

Kinase-interacting protein 2; KIP 2

Protein Family

Calcium and integrin-binding family

UniProt Gene Name

CIB2

UniProt Synonym Gene Names

KIP2; KIP 2

NCBI Protein Information

calcium and integrin-binding family member 2

NCBI Summary for CIB2

The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

UniProt Comments for CIB2

Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331, PubMed:26173970, PubMed:26426422). May be involved in the mechanotransduction process ().

Research Articles on CIB2

1. results suggest that GJB2 and CIB2 are common cause of hearing loss in different Pakistani ethnicities

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with CIB2 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>16 publications with CIB2 and Nervous System Diseases
Disease Models, Animal Antibodies	>2 publications with CIB2 and Disease Models, Animal
Deafness, Autosomal Recessive 48 Antibodies	>2 publications with CIB2 and Deafness, Autosomal Recessive 48
Cell Transformation, Neoplastic Antibodies	>1 publications with CIB2 and Cell Transformation, Neoplastic
USHER SYNDROME, TYPE IJ Antibodies	>1 publications with CIB2 and USHER SYNDROME, TYPE IJ

Organs/Tissues associated with CIB2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>3 publications with CIB2 and Muscle
Eye Antibodies	>2 publications with CIB2 and Eye
Testis Antibodies	>2 publications with CIB2 and Testis
Brain Antibodies	>2 publications with CIB2 and Brain
Skin Antibodies	>1 publications with CIB2 and Skin