HNRNPC Recombinant Protein

Name: HNRNPC Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203834
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203834

HNRNPC, also known as hnRNP C1/C2, belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HNRNPC, Recombinant Protein

Full Product Name

HNRNPC, 1-293aa, Human, His tag, E Coli

Product Gene Name

HNRNPC recombinant protein

Product Synonym Names

Heterogeneous nuclear ribonucleoprotein C (C1/C2); C1; C2; HNRNP; HNRPC; SNRPC

Sequence

MGSSHHHHHH SSGLVPRGSH MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSSFD LDYDFQRDYY DRMYSYPARV PPPPPIARAV VPSKRQRVSG NTSRRGKSGF NSKSGQRGSS KSGKLKGDDL QAIKKELTQI KQKVDSLLEN LEKIEKEQSK QAVEMKNDKS EEEQSSSSVK KDETNVKMES EGGADDSAEE GDLLDDDDNE DRGDDQLELI KDDEKEAEEG EDDRDSANGE DDS

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 30% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

34.5 kDa (313aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

OMIM

M29063 mRNA

3D Structure

ModBase 3D Structure for P07910

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for HNRNPC recombinant protein

Signal Transduction

Applications Tested/Suitable for HNRNPC recombinant protein

SDS-PAGE

Product References and Citations for HNRNPC recombinant protein

Hayakawa H., et al. (2010) Biochem Biophys Res Commun. 403 (2):220-4.; Stone JR., et al. (2002) J Biol Chem. 277 (18):15621-8.

Other Notes

Small volumes of HNRNPC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HNRNPC purchase

MBS203834 is a recombinant protein targeting HNRNPC. Also known as HNRNPC, 1-293aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HNRNPC. It may not necessarily be applicable to this product.

NCBI GI #

117190174

NCBI GeneID

3183

NCBI Accession #

NP_004491

UniProt Primary Accession #

P07910

UniProt Secondary Accession #

P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; D3DS19; D3DS22

UniProt Related Accession #

P07910

GenBank Nucleotide #

NM_004500.3

NCBI Official Full Name

heterogeneous nuclear ribonucleoproteins C1/C2 isoform b

NCBI Official Synonym Full Names

heterogeneous nuclear ribonucleoprotein C (C1/C2)

NCBI Official Symbol

HNRNPC

NCBI Official Synonym Symbols

C1; C2; HNRNP; HNRPC; SNRPC

UniProt Protein Name

Heterogeneous nuclear ribonucleoproteins C1/C2

Protein Family

Heterogeneous nuclear ribonucleoprotein

UniProt Gene Name

HNRNPC

UniProt Synonym Gene Names

HNRPC; hnRNP C1/C2

NCBI Protein Information

heterogeneous nuclear ribonucleoproteins C1/C2

NCBI Summary for HNRNPC

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for HNRNPC

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

Research Articles on HNRNPC

1. APP levels then decrease progressively as a function of age in close relationship with the gradual normalization of FMRP and hnRNP C levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HNRNPC recombinant protein

Reference Product	PubMed Publications
DHX9 recombinant protein	>3 publications with HNRNPC and DHX9
HNRNPD recombinant protein	>1 publications with HNRNPC and HNRNPD
U2AF2 recombinant protein	>1 publications with HNRNPC and U2AF2
HNRNPA1 recombinant protein	>1 publications with HNRNPC and HNRNPA1

Pathways associated with HNRNPC recombinant protein

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies	Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
Regulation Of Telomerase Pathway antibodies	Regulation Of Telomerase Pathway Diagram
SUMO E3 Ligases SUMOylate Target Proteins Pathway antibodies	SUMO E3 Ligases SUMOylate Target Proteins Pathway Diagram
SUMOylation Pathway antibodies	SUMOylation Pathway Diagram
SUMOylation Of RNA Binding Proteins Pathway antibodies	SUMOylation Of RNA Binding Proteins Pathway Diagram
Spliceosome Pathway antibodies	Spliceosome Pathway Diagram
Spliceosome Pathway antibodies	Spliceosome Pathway Diagram

Diseases associated with HNRNPC recombinant protein

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>3 publications with HNRNPC and Lung Diseases
Lung Neoplasms Antibodies	>3 publications with HNRNPC and Lung Neoplasms
Breast Neoplasms Antibodies	>3 publications with HNRNPC and Breast Neoplasms
Adenocarcinoma Antibodies	>3 publications with HNRNPC and Adenocarcinoma
Carcinoma, Hepatocellular Antibodies	>2 publications with HNRNPC and Carcinoma, Hepatocellular
Inflammation Antibodies	>2 publications with HNRNPC and Inflammation
Neurobehavioral Manifestations Antibodies	>1 publications with HNRNPC and Neurobehavioral Manifestations
Abnormalities, Multiple Antibodies	>1 publications with HNRNPC and Abnormalities, Multiple
Liver Neoplasms Antibodies	>1 publications with HNRNPC and Liver Neoplasms
Hemorrhage Antibodies	>1 publications with HNRNPC and Hemorrhage

Organs/Tissues associated with HNRNPC recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>8 publications with HNRNPC and Lung
Liver Antibodies	>7 publications with HNRNPC and Liver
Brain Antibodies	>6 publications with HNRNPC and Brain
Kidney Antibodies	>2 publications with HNRNPC and Kidney
Embryonic Tissue Antibodies	>2 publications with HNRNPC and Embryonic Tissue
Nerve Antibodies	>2 publications with HNRNPC and Nerve
Ovary Antibodies	>2 publications with HNRNPC and Ovary
Testis Antibodies	>2 publications with HNRNPC and Testis
Stomach Antibodies	>1 publications with HNRNPC and Stomach
Lymph Antibodies	>1 publications with HNRNPC and Lymph