RGS2 Recombinant Protein

Name: RGS2 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203962
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203962

RGS2, also known as G0S8, is a RGS family member and regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha… More details

$280 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RGS2, Recombinant Protein

Full Product Name

RGS2, 1-211aa, Human, His tag, E Coli

Product Gene Name

RGS2 recombinant protein

Product Synonym Names

Regulator of G-protein signaling 2 24kDa; G0S8

Sequence

MGSSHHHHHH SSGLVPRGSH MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK KPQITTEPHA T

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

26.5 kDa (231aa) confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appear higher)

OMIM

L13391 Genomic DNA

3D Structure

ModBase 3D Structure for P41220

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for RGS2 recombinant protein

Signal Transduction

Applications Tested/Suitable for RGS2 recombinant protein

SDS-PAGE

Product References and Citations for RGS2 recombinant protein

Tang KM., et al. (2003) Nat Med. 9 (12):1506-12. ; Santos de Araujo RM., et al. (2007) Cell Biochem Funct. 25 (6):753-8.

Other Notes

Small volumes of RGS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RGS2 purchase

MBS203962 is a recombinant protein targeting RGS2. Also known as RGS2, 1-211aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RGS2. It may not necessarily be applicable to this product.

NCBI GI #

4506517

NCBI GeneID

5997

NCBI Accession #

NP_002914

UniProt Primary Accession #

P41220

UniProt Secondary Accession #

Q6I9U5

UniProt Related Accession #

P41220

GenBank Nucleotide #

NM_002923.3

NCBI Official Full Name

regulator of G-protein signaling 2

NCBI Official Synonym Full Names

regulator of G protein signaling 2

NCBI Official Symbol

RGS2

NCBI Official Synonym Symbols

G0S8

UniProt Protein Name

Regulator of G-protein signaling 2

UniProt Synonym Protein Names

Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8

Protein Family

Regulator of G-protein signaling

UniProt Gene Name

RGS2

UniProt Synonym Gene Names

G0S8; RGS2

NCBI Protein Information

regulator of G-protein signaling 2

NCBI Summary for RGS2

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

UniProt Comments for RGS2

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).

Research Articles on RGS2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RGS2 recombinant protein

Reference Product	PubMed Publications
ADCY3 recombinant protein	>2 publications with RGS2 and ADCY3
PRKG1 recombinant protein	>2 publications with RGS2 and PRKG1
GNA14 recombinant protein	>1 publications with RGS2 and GNA14

Pathways associated with RGS2 recombinant protein

Products by Pathway	Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
Olfactory Transduction Pathway antibodies	Olfactory Transduction Pathway Diagram
Olfactory Transduction Pathway antibodies	Olfactory Transduction Pathway Diagram
Oxytocin Signaling Pathway antibodies	Oxytocin Signaling Pathway Diagram
Oxytocin Signaling Pathway antibodies	Oxytocin Signaling Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with RGS2 recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>80 publications with RGS2 and Cardiovascular Diseases
Hypertension Antibodies	>69 publications with RGS2 and Hypertension
Nervous System Diseases Antibodies	>25 publications with RGS2 and Nervous System Diseases
Heart Diseases Antibodies	>25 publications with RGS2 and Heart Diseases
Disease Models, Animal Antibodies	>23 publications with RGS2 and Disease Models, Animal
Inflammation Antibodies	>21 publications with RGS2 and Inflammation
Brain Diseases Antibodies	>17 publications with RGS2 and Brain Diseases
Fibrosis Antibodies	>8 publications with RGS2 and Fibrosis
Necrosis Antibodies	>7 publications with RGS2 and Necrosis
Kidney Diseases Antibodies	>7 publications with RGS2 and Kidney Diseases

Organs/Tissues associated with RGS2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>98 publications with RGS2 and Blood
Muscle Antibodies	>95 publications with RGS2 and Muscle
Brain Antibodies	>84 publications with RGS2 and Brain
Vascular Antibodies	>66 publications with RGS2 and Vascular
Heart Antibodies	>66 publications with RGS2 and Heart
Kidney Antibodies	>31 publications with RGS2 and Kidney
Nerve Antibodies	>20 publications with RGS2 and Nerve
Bone Antibodies	>16 publications with RGS2 and Bone
Lung Antibodies	>15 publications with RGS2 and Lung
Ovary Antibodies	>14 publications with RGS2 and Ovary