SNRPE Recombinant Protein

Name: SNRPE Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204018
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204018

SNRPE, also known as SME, aids in the cytoplasmic construction of the usnRNPs by binding to a conserved Sm site on usnRNA and forming a stable snRNP core complex. As a core protein to usnRNP, the SNRPE associates with the entire u family of snRNAs including… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SNRPE, Recombinant Protein

Full Product Name

SNRPE, 1-92aa, Human, His tag, E Coli

Product Gene Name

SNRPE recombinant protein

Product Synonym Names

Small nuclear ribonucleoprotein E; B-raf; Sm-E; SME

Sequence

MGSSHHHHHH SSGLVPRGSH MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 1mM EDTA, 30% glycerol

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

12.9 kDa (112aa), confirmed by MALDI-TOF

OMIM

M37716 mRNA

3D Structure

ModBase 3D Structure for P62304

Antigen Species

Human

Tag Information

His-tag

Applications Tested/Suitable for SNRPE recombinant protein

SDS-PAGE

Product References and Citations for SNRPE recombinant protein

Campion Y., et al. (2010) EMBO J. 29 (11):1817-29.; Dong X., et al. (2009) Nature. 458 (7242):1136-41.

Other Notes

Small volumes of SNRPE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNRPE purchase

MBS204018 is a recombinant protein targeting SNRPE. Also known as SNRPE, 1-92aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SNRPE. It may not necessarily be applicable to this product.

NCBI GI #

4507129

NCBI GeneID

6635

NCBI Accession #

NP_003085

UniProt Primary Accession #

P62304

UniProt Secondary Accession #

P08578; Q15498; Q5BKT2; B2R5B9

UniProt Related Accession #

P62304

GenBank Nucleotide #

NM_003094.3

NCBI Official Full Name

small nuclear ribonucleoprotein E isoform 1

NCBI Official Synonym Full Names

small nuclear ribonucleoprotein polypeptide E

NCBI Official Symbol

SNRPE

NCBI Official Synonym Symbols

SME; Sm-E; HYPT11; snRNP-E

UniProt Protein Name

Small nuclear ribonucleoprotein E

UniProt Synonym Protein Names

Sm protein E; Sm-E; SmE

Protein Family

Small nuclear ribonucleoprotein

UniProt Gene Name

SNRPE

UniProt Synonym Gene Names

snRNP-E; Sm-E; SmE

NCBI Protein Information

small nuclear ribonucleoprotein E

NCBI Summary for SNRPE

The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]

UniProt Comments for SNRPE

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.

Research Articles on SNRPE

1. Overexpression of SNRPE is associated with highly aggressive breast cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SNRPE recombinant protein

Reference Product	PubMed Publications
SNRPF recombinant protein	>9 publications with SNRPE and SNRPF
SNRPD1 recombinant protein	>3 publications with SNRPE and SNRPD1
SNRPB recombinant protein	>2 publications with SNRPE and SNRPB
SNRPD3 recombinant protein	>1 publications with SNRPE and SNRPD3

Pathways associated with SNRPE recombinant protein

Products by Pathway	Pathway Diagram
Cleavage Of Growing Transcript In The Termination Region Pathway antibodies	Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Metabolism Of Non-coding RNA Pathway antibodies	Metabolism Of Non-coding RNA Pathway Diagram
Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies	Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
Processing Of Capped Intronless Pre-mRNA Pathway antibodies	Processing Of Capped Intronless Pre-mRNA Pathway Diagram
RNA Polymerase II Transcription Pathway antibodies	RNA Polymerase II Transcription Pathway Diagram
RNA Polymerase II Transcription Termination Pathway antibodies	RNA Polymerase II Transcription Termination Pathway Diagram
SLBP Dependent Processing Of Replication-Dependent Histone Pre-mRNAs Pathway antibodies	SLBP Dependent Processing Of Replication-Dependent Histone Pre-mRNAs Pathway Diagram
SLBP Independent Processing Of Histone Pre-mRNAs Pathway antibodies	SLBP Independent Processing Of Histone Pre-mRNAs Pathway Diagram
Sm Core Complex Pathway antibodies	Sm Core Complex Pathway Diagram

Diseases associated with SNRPE recombinant protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>3 publications with SNRPE and Adenocarcinoma
Liver Diseases Antibodies	>3 publications with SNRPE and Liver Diseases
Lung Neoplasms Antibodies	>2 publications with SNRPE and Lung Neoplasms
Carcinoma, Hepatocellular Antibodies	>2 publications with SNRPE and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>2 publications with SNRPE and Liver Neoplasms
Hypotrichosis Antibodies	>2 publications with SNRPE and Hypotrichosis
Infertility, Male Antibodies	>1 publications with SNRPE and Infertility, Male
Urinary Bladder Neoplasms Antibodies	>1 publications with SNRPE and Urinary Bladder Neoplasms
Breast Neoplasms Antibodies	>1 publications with SNRPE and Breast Neoplasms
Fatty Liver Antibodies	>1 publications with SNRPE and Fatty Liver

Organs/Tissues associated with SNRPE recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with SNRPE and Liver
Lung Antibodies	>2 publications with SNRPE and Lung
Prostate Antibodies	>2 publications with SNRPE and Prostate
Blood Antibodies	>2 publications with SNRPE and Blood
Bladder Antibodies	>1 publications with SNRPE and Bladder
Connective Tissue Antibodies	>1 publications with SNRPE and Connective Tissue
Thyroid Antibodies	>1 publications with SNRPE and Thyroid
Skin Antibodies	>1 publications with SNRPE and Skin
Muscle Antibodies	>1 publications with SNRPE and Muscle
Testis Antibodies	>1 publications with SNRPE and Testis