YARS Recombinant Protein

Name: YARS Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204026
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204026

Tyrosyl-tRNA synthetase, also known as YARS, belongs to the class I tRNA synthetase family. YARS is essential enzyme that catalyze the aminoacylation of tRNATrp with tryptophan, an essential function of the cell's protein synthesis machinery. Expression of… More details

$265 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

YARS, Recombinant Protein

Full Product Name

YARS, 1-528aa, Human, His tag, E Coli

Product Gene Name

YARS recombinant protein

Product Synonym Names

Tyrosyl-tRNA synthetase; CMTDIC; TYRRS; YRS; YTS

Sequence

MGSSHHHHHH SSGLVPRGSH MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM AKGPAKNSEP EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCK SLKGGNIS

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

61.3 kDa (548aa)

OMIM

U40714 mRNA

3D Structure

ModBase 3D Structure for P54577

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for YARS recombinant protein

Signal Transduction

Applications Tested/Suitable for YARS recombinant protein

SDS-PAGE

Product References and Citations for YARS recombinant protein

Kise Y., et al. (2004) Nat Struct Mol Biol. 11:149-156.; Wakasugi K., et al. (2002) Proc Natl Acad Sci. 99:173-177.

Other Notes

Small volumes of YARS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YARS purchase

MBS204026 is a recombinant protein targeting YARS. Also known as YARS, 1-528aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for YARS. It may not necessarily be applicable to this product.

NCBI GI #

4507947

NCBI GeneID

8565

NCBI Accession #

NP_003671

UniProt Primary Accession #

P54577

UniProt Secondary Accession #

O43276; Q53EN1; B3KWK4; D3DPQ4

UniProt Related Accession #

P54577

GenBank Nucleotide #

NM_003680.3

NCBI Official Full Name

tyrosine--tRNA ligase, cytoplasmic

NCBI Official Synonym Full Names

tyrosyl-tRNA synthetase

NCBI Official Symbol

YARS

NCBI Official Synonym Symbols

YRS; YTS; TYRRS; CMTDIC

UniProt Protein Name

Tyrosine--tRNA ligase, cytoplasmic

UniProt Synonym Protein Names

Tyrosyl-tRNA synthetase; TyrRS

Protein Family

Tyrosine--tRNA ligase

UniProt Gene Name

YARS

UniProt Synonym Gene Names

TyrRS

NCBI Protein Information

tyrosine--tRNA ligase, cytoplasmic

NCBI Summary for YARS

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

UniProt Comments for YARS

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Research Articles on YARS

1. These YARS variants occur in the catalytic domain and the C-terminal domain, respectively. Mutations in YARS have been previously associated with an autosomal dominant form of Charcot-Marie-Tooth (CMT); our findings suggest the disease spectrum associated with YARS dysregulation is broader than peripheral neuropathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with YARS recombinant protein

Reference Product	PubMed Publications
GARS recombinant protein	>6 publications with YARS and GARS
AARS recombinant protein	>3 publications with YARS and AARS
QARS recombinant protein	>1 publications with YARS and QARS
MARS recombinant protein	>1 publications with YARS and MARS
EPRS recombinant protein	>1 publications with YARS and EPRS

Pathways associated with YARS recombinant protein

Products by Pathway	Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Cytosolic TRNA Aminoacylation Pathway antibodies	Cytosolic TRNA Aminoacylation Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
TRNA Aminoacylation Pathway antibodies	TRNA Aminoacylation Pathway Diagram

Diseases associated with YARS recombinant protein

Disease Name	Pubmed Publications
Nerve Degeneration Antibodies	>5 publications with YARS and Nerve Degeneration
Disease Models, Animal Antibodies	>5 publications with YARS and Disease Models, Animal
Cardiovascular Diseases Antibodies	>5 publications with YARS and Cardiovascular Diseases
Brain Diseases Antibodies	>3 publications with YARS and Brain Diseases
Pain Antibodies	>3 publications with YARS and Pain
Inflammation Antibodies	>2 publications with YARS and Inflammation
Lung Diseases Antibodies	>2 publications with YARS and Lung Diseases
Hypertension Antibodies	>1 publications with YARS and Hypertension
Liver Neoplasms Antibodies	>1 publications with YARS and Liver Neoplasms
Heart Diseases Antibodies	>1 publications with YARS and Heart Diseases

Organs/Tissues associated with YARS recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>9 publications with YARS and Nerve
Blood Antibodies	>5 publications with YARS and Blood
Brain Antibodies	>5 publications with YARS and Brain
Liver Antibodies	>3 publications with YARS and Liver
Vascular Antibodies	>2 publications with YARS and Vascular
Lung Antibodies	>2 publications with YARS and Lung
Heart Antibodies	>2 publications with YARS and Heart
Ovary Antibodies	>1 publications with YARS and Ovary
Embryonic Tissue Antibodies	>1 publications with YARS and Embryonic Tissue
Skin Antibodies	>1 publications with YARS and Skin