CDCA8 Recombinant Protein

Name: CDCA8 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204057
Price: 255 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204057

CDCA8, also known as Borealin, is a component of the chromosomal passenger complex (CPC). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CDCA8, Recombinant Protein

Full Product Name

CDCA8, 19-280aa, Human, His tag, E Coli

Product Gene Name

CDCA8 recombinant protein

Product Synonym Names

Cell division cycle-associated protein 8; Borealin; Dasra-B; PESCRG3

Sequence

MGSSHHHHHH SSGLVPRGSH MRKLASFLKD FDREVEIRIK QIESDRQNLL KEVDNLYNIE ILRLPKALRE MNWLDYFALG GNKQALEEAA TADLDITEIN KLTAEAIQTP LKSAKTRKVI QVDEMIVEEE EEEENERKNL QTARVKRCPP SKKRTQSIQG KGKGKRSSRA NTVTPAVGRL EVSMVKPTPG LTPRFDSRVF KTPGLRTPAA GERIYNISGN GSPLADSKEI FLTVPVGGGE SLRLLASDLQ RHSIAQLDPE ALGNIKKLSN RLAQICSSIR THK

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 1mM EDTA, 0.2M NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

31.6 kDa (283aa) confirmed by MALDI-TOF

OMIM

BG354581 mRNA

3D Structure

ModBase 3D Structure for Q53HL2

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for CDCA8 recombinant protein

Cell Cycle

Applications Tested/Suitable for CDCA8 recombinant protein

SDS-PAGE

Product References and Citations for CDCA8 recombinant protein

Gassmann R., et al. (2004) J Cell Biol.166:179-191.; Chang J L., et al. (2006) EXP Cell Res. 312:962-973.

Other Notes

Small volumes of CDCA8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDCA8 purchase

MBS204057 is a recombinant protein targeting CDCA8. Also known as CDCA8, 19-280aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CDCA8. It may not necessarily be applicable to this product.

NCBI GI #

8922438

NCBI GeneID

55143

NCBI Accession #

NP_060571

UniProt Primary Accession #

Q53HL2

UniProt Secondary Accession #

Q53HN1; Q96AM3; Q9NVW5; D3DPT4

UniProt Related Accession #

Q53HL2

GenBank Nucleotide #

NM_018101.3

NCBI Official Full Name

borealin

NCBI Official Synonym Full Names

cell division cycle associated 8

NCBI Official Symbol

CDCA8

NCBI Official Synonym Symbols

BOR; DasraB; MESRGP; BOREALIN

UniProt Protein Name

Borealin

UniProt Synonym Protein Names

Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein

UniProt Gene Name

CDCA8

UniProt Synonym Gene Names

PESCRG3; hDasra-B

NCBI Protein Information

borealin

NCBI Summary for CDCA8

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

UniProt Comments for CDCA8

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.

Research Articles on CDCA8

1. These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDCA8 recombinant protein

Reference Product	PubMed Publications
BIRC5 recombinant protein	>33 publications with CDCA8 and BIRC5
AURKB recombinant protein	>31 publications with CDCA8 and AURKB
INCENP recombinant protein	>30 publications with CDCA8 and INCENP
CDK1 recombinant protein	>7 publications with CDCA8 and CDK1
BUB1 recombinant protein	>4 publications with CDCA8 and BUB1
KIF2C recombinant protein	>4 publications with CDCA8 and KIF2C
CDC20 recombinant protein	>3 publications with CDCA8 and CDC20
CCNB1 recombinant protein	>2 publications with CDCA8 and CCNB1
KIF20A recombinant protein	>1 publications with CDCA8 and KIF20A
CENPE recombinant protein	>1 publications with CDCA8 and CENPE

Pathways associated with CDCA8 recombinant protein

Products by Pathway	Pathway Diagram
Aurora B Signaling Pathway antibodies	Aurora B Signaling Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Mitotic Anaphase Pathway antibodies	Mitotic Anaphase Pathway Diagram
Mitotic Metaphase And Anaphase Pathway antibodies	Mitotic Metaphase And Anaphase Pathway Diagram
Mitotic Prometaphase Pathway antibodies	Mitotic Prometaphase Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
RHO GTPase Effectors Pathway antibodies	RHO GTPase Effectors Pathway Diagram

Diseases associated with CDCA8 recombinant protein

Disease Name	Pubmed Publications
Ovarian Neoplasms Antibodies	>4 publications with CDCA8 and Ovarian Neoplasms
Carcinoma, Hepatocellular Antibodies	>3 publications with CDCA8 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>3 publications with CDCA8 and Liver Diseases
Liver Neoplasms Antibodies	>3 publications with CDCA8 and Liver Neoplasms
Lung Diseases Antibodies	>2 publications with CDCA8 and Lung Diseases
Cell Transformation, Neoplastic Antibodies	>2 publications with CDCA8 and Cell Transformation, Neoplastic
Lung Neoplasms Antibodies	>2 publications with CDCA8 and Lung Neoplasms
Neoplasm Metastasis Antibodies	>2 publications with CDCA8 and Neoplasm Metastasis
Anemia Antibodies	>1 publications with CDCA8 and Anemia
Breast Neoplasms Antibodies	>1 publications with CDCA8 and Breast Neoplasms

Organs/Tissues associated with CDCA8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>4 publications with CDCA8 and Embryonic Tissue
Blood Antibodies	>3 publications with CDCA8 and Blood
Uterus Antibodies	>2 publications with CDCA8 and Uterus
Bone Antibodies	>2 publications with CDCA8 and Bone
Lung Antibodies	>2 publications with CDCA8 and Lung
Stomach Antibodies	>2 publications with CDCA8 and Stomach
Liver Antibodies	>2 publications with CDCA8 and Liver
Cervix Antibodies	>1 publications with CDCA8 and Cervix
Lymph Node Antibodies	>1 publications with CDCA8 and Lymph Node
Kidney Antibodies	>1 publications with CDCA8 and Kidney