MAGEA6 Recombinant Protein

Name: MAGEA6 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204180
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204180

MAGEA6 is a member of the MAGEA family, which directs the expression of tumor antigens that are recognized on a human melanoma by autologous cytolytic T lymphocytes (CTL). The MAGE genes were initially isolated from different kinds of tumors, and based on… More details

$230 / 0.004 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAGEA6, Recombinant Protein

Full Product Name

MAGEA6, 1-314aa, Human, His tag, E Coli

Product Gene Name

MAGEA6 recombinant protein

Product Synonym Names

Melanoma-associated antigen 6; CT1.6; MAGE-3b; MAGE3B; MAGE6

Sequence

MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS YPLLHEWALR EGEELEHHHH HH

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

35.9 kDa (322aa), confirmed by MALDI-TOF

OMIM

U10691 Genomic DNA

3D Structure

ModBase 3D Structure for P43360

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for MAGEA6 recombinant protein

Cancer

Applications Tested/Suitable for MAGEA6 recombinant protein

SDS-PAGE

Product References and Citations for MAGEA6 recombinant protein

Kobayasshi Y., et al. (2000) J Hepatol. 32:612-617.; Klein C., et al. (2000) J Exp Med. 191: 1699-1708.

Other Notes

Small volumes of MAGEA6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAGEA6 purchase

MBS204180 is a recombinant protein targeting MAGEA6. Also known as MAGEA6, 1-314aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGEA6. It may not necessarily be applicable to this product.

NCBI GI #

4885469

NCBI GeneID

4105

NCBI Accession #

NP_005354

UniProt Primary Accession #

P43360

UniProt Secondary Accession #

Q6NW44; A8IF93

UniProt Related Accession #

P43360

GenBank Nucleotide #

NM_005363.3

NCBI Official Full Name

melanoma-associated antigen 6

NCBI Official Synonym Full Names

MAGE family member A6

NCBI Official Symbol

MAGEA6

NCBI Official Synonym Symbols

CT1.6; MAGE6; MAGE3B; MAGE-3b

UniProt Protein Name

Melanoma-associated antigen 6

UniProt Synonym Protein Names

Cancer/testis antigen 1.6; CT1.6; MAGE-6 antigen; MAGE3B antigen

Protein Family

Melanoma-associated antigen

UniProt Gene Name

MAGEA6

UniProt Synonym Gene Names

MAGE6; CT1.6

NCBI Protein Information

melanoma-associated antigen 6

NCBI Summary for MAGEA6

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

UniProt Comments for MAGEA6

Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

Research Articles on MAGEA6

1. MAGEA6 promotes glioma cell survival possibly via targeting AMPKalpha1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.