CRCP Recombinant Protein

Name: CRCP Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204197
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204197

CRCP, also known as CGRP-RCP, is an ubiquitous coupling protein for the calcitonin gene-related peptide and adrenomedullin receptors. It modulates ligand responsiveness in a variety of tissues. It has been DNA-directed RNA polymerase activity, catalytic… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CRCP, Recombinant Protein

Full Product Name

CRCP, 1-148aa, Human, His, E Coli

Product Gene Name

CRCP recombinant protein

Product Synonym Names

DNA-directed RNA polymerase III subunit RPC9; CGRP-RCP; CGRPRCP; MGC111194; RCP; RCP9

Sequence

MGSSHHHHHH SSGLVPRGSH MEVKDANSAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCRH QSPEIVREFL TALKSHKLTK AEKLQLLNHR PVTAVEIQLM VEESEERLTE EQIEALLHTV TSILPAEPEA EQKKNTNSNV AMDEEDPA

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

19.0 kDa (168aa), confirmed by MALDI-TOF

OMIM

AF073792 mRNA

3D Structure

ModBase 3D Structure for O75575

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for CRCP recombinant protein

Neuroscience

Applications Tested/Suitable for CRCP recombinant protein

SDS-PAGE

Product References and Citations for CRCP recombinant protein

Evans B.N. et al. (2000) J Biol Chem. 275: 31438-31443.; Sams A. et al. (1999) Regul. Pept. 85: 67-75.

Other Notes

Small volumes of CRCP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRCP purchase

MBS204197 is a recombinant protein targeting CRCP. Also known as CRCP, 1-148aa, Human, His, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CRCP. It may not necessarily be applicable to this product.

NCBI GI #

7656977

NCBI GeneID

27297

NCBI Accession #

NP_055293

UniProt Primary Accession #

O75575

UniProt Secondary Accession #

Q3KRA3; Q5HYF1; Q8IXL4; A8MUZ4; A8MW23; B2R4H4; B4E198

UniProt Related Accession #

O75575

GenBank Nucleotide #

NP_055293.1

NCBI Official Full Name

DNA-directed RNA polymerase III subunit RPC9 isoform a

NCBI Official Synonym Full Names

CGRP receptor component

NCBI Official Symbol

CRCP

NCBI Official Synonym Symbols

RCP; RCP9; CGRPRCP; CGRP-RCP

UniProt Protein Name

DNA-directed RNA polymerase III subunit RPC9

UniProt Synonym Protein Names

Calcitonin gene-related peptide-receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17

UniProt Gene Name

CRCP

UniProt Synonym Gene Names

RNA polymerase III subunit C9; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17

NCBI Protein Information

DNA-directed RNA polymerase III subunit RPC9

NCBI Summary for CRCP

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for CRCP

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway ().

Research Articles on CRCP

1. data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CRCP recombinant protein

Products by Pathway	Pathway Diagram
Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies	Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies	RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
RNA Polymerase III Abortive And Retractive Initiation Pathway antibodies	RNA Polymerase III Abortive And Retractive Initiation Pathway Diagram
RNA Polymerase III Chain Elongation Pathway antibodies	RNA Polymerase III Chain Elongation Pathway Diagram
RNA Polymerase III Transcription Pathway antibodies	RNA Polymerase III Transcription Pathway Diagram
RNA Polymerase III Transcription Initiation Pathway antibodies	RNA Polymerase III Transcription Initiation Pathway Diagram

Diseases associated with CRCP recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>44 publications with CRCP and Nervous System Diseases
Cardiovascular Diseases Antibodies	>21 publications with CRCP and Cardiovascular Diseases
Vascular Diseases Antibodies	>20 publications with CRCP and Vascular Diseases
Inflammation Antibodies	>10 publications with CRCP and Inflammation
Prostatic Neoplasms Antibodies	>8 publications with CRCP and Prostatic Neoplasms
Hypertension Antibodies	>8 publications with CRCP and Hypertension
Pain Antibodies	>7 publications with CRCP and Pain
Fibrosis Antibodies	>7 publications with CRCP and Fibrosis
Hemorrhage Antibodies	>5 publications with CRCP and Hemorrhage
Growth Disorders Antibodies	>3 publications with CRCP and Growth Disorders

Organs/Tissues associated with CRCP recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>70 publications with CRCP and Blood
Vascular Antibodies	>48 publications with CRCP and Vascular
Brain Antibodies	>39 publications with CRCP and Brain
Muscle Antibodies	>20 publications with CRCP and Muscle
Heart Antibodies	>20 publications with CRCP and Heart
Prostate Antibodies	>8 publications with CRCP and Prostate
Connective Tissue Antibodies	>7 publications with CRCP and Connective Tissue
Liver Antibodies	>5 publications with CRCP and Liver
Uterus Antibodies	>3 publications with CRCP and Uterus
Bone Antibodies	>3 publications with CRCP and Bone