QDPR Recombinant Protein

Name: QDPR Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204221
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204221

QDPR is a member of the short-chain dehydrogenases/reductase (SDR) family of enzymes. Functioning as a homodimer, QDPR plays an important role in the recycling of tetrahydrobiopterin (BH4), an essential cofactor for the hydroxylation of the aromatic amino… More details

$245 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

QDPR, Recombinant Protein

Full Product Name

QDPR, 1-244aa, Human, His tag, E Coli

Product Gene Name

QDPR recombinant protein

Product Synonym Names

Quinoid dihydropteridine reductase.; DHPR; FLJ42391; PKu2; SDR33C1

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAAAAAA GEARRVLVYG GRGALGSRCV QAFRARNWWV ASVDVVENEE ASASIIVKMT DSFTEQADQV TAEVGKLLGE EKVDAILCVA GGWAGGNAKS KSLFKNCDLM WKQSIWTSTI SSHLATKHLK EGGLLTLAGA KAALDGTPGM IGYGMAKGAV HQLCQSLAGK NSGMPPGAAA IAVLPVTLDT PMNRKSMPEA DFSSWTPLEF LVETFHDWIT GKNRPSSGSL IQVVTTEGRT ELTPAYF

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.5) containing 10% glycerol, 0.1M NaCl, 2mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

28.2 kDa (267aa), confirmed by MALDI-TOF

OMIM

X04882 mRNA

3D Structure

ModBase 3D Structure for P09417

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for QDPR recombinant protein

Metabolism

Applications Tested/Suitable for QDPR recombinant protein

SDS-PAGE

Product References and Citations for QDPR recombinant protein

Lye LF., et al. (2002) J Biol Chem. 277 (41):38245-53.; Kalkanoqlu HS., et al. (2001) Prenat Diagn. 21 (10):868-70.

Other Notes

Small volumes of QDPR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for QDPR purchase

MBS204221 is a recombinant protein targeting QDPR. Also known as QDPR, 1-244aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for QDPR. It may not necessarily be applicable to this product.

NCBI GI #

208973246

NCBI GeneID

5860

NCBI Accession #

NP_000311

UniProt Primary Accession #

P09417

UniProt Secondary Accession #

Q53F52; Q9H3M5; A8K158; B3KW71

UniProt Related Accession #

P09417

GenBank Nucleotide #

NM_000320.2

NCBI Official Full Name

dihydropteridine reductase isoform 1

NCBI Official Synonym Full Names

quinoid dihydropteridine reductase

NCBI Official Symbol

QDPR

NCBI Official Synonym Symbols

DHPR; PKU2; SDR33C1

UniProt Protein Name

Dihydropteridine reductase

UniProt Synonym Protein Names

HDHPR; Quinoid dihydropteridine reductase; Short chain dehydrogenase/reductase family 33C member 1

Protein Family

Dihydropteridine reductase

UniProt Gene Name

QDPR

UniProt Synonym Gene Names

DHPR; SDR33C1

NCBI Protein Information

dihydropteridine reductase

NCBI Summary for QDPR

This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]

UniProt Comments for QDPR

The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.

Research Articles on QDPR

1. The allele frequencies for the QDPR c.68G > A(0.3%) polymorphism is not a major cause of Parkinson's disease in the Maltese.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with QDPR recombinant protein

Reference Product	PubMed Publications
GCH1 recombinant protein	>8 publications with QDPR and GCH1
PAH recombinant protein	>8 publications with QDPR and PAH
SPR recombinant protein	>4 publications with QDPR and SPR
PCBD1 recombinant protein	>4 publications with QDPR and PCBD1

Pathways associated with QDPR recombinant protein

Products by Pathway	Pathway Diagram
Folate Biosynthesis Pathway antibodies	Folate Biosynthesis Pathway Diagram
Folate Biosynthesis Pathway antibodies	Folate Biosynthesis Pathway Diagram
Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway antibodies	Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway Diagram
L-phenylalanine Degradation I (aerobic) Pathway antibodies	L-phenylalanine Degradation I (aerobic) Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Phenylalanine And Tyrosine Catabolism Pathway antibodies	Phenylalanine And Tyrosine Catabolism Pathway Diagram
Phenylalanine Degradation/tyrosine Biosynthesis Pathway antibodies	Phenylalanine Degradation/tyrosine Biosynthesis Pathway Diagram

Diseases associated with QDPR recombinant protein

Disease Name	Pubmed Publications
Phenylketonurias Antibodies	>12 publications with QDPR and Phenylketonurias
HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C Antibodies	>12 publications with QDPR and HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C
Cognition Disorders Antibodies	>4 publications with QDPR and Cognition Disorders
Atrophy Antibodies	>1 publications with QDPR and Atrophy
Mitochondrial Diseases Antibodies	>1 publications with QDPR and Mitochondrial Diseases
Fibrosis Antibodies	>1 publications with QDPR and Fibrosis

Organs/Tissues associated with QDPR recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with QDPR and Blood
Brain Antibodies	>6 publications with QDPR and Brain
Kidney Antibodies	>3 publications with QDPR and Kidney
Nerve Antibodies	>2 publications with QDPR and Nerve
Lung Antibodies	>1 publications with QDPR and Lung
Liver Antibodies	>1 publications with QDPR and Liver