• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PPP1R8 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204250

PPP1R8, also as known as NIPP-1, is the RNA-binding subunit of a major species of protein phosphatase-1 in the nucleus. This enzyme is inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and… More details

$230 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PPP1R8, Recombinant Protein
Full Product Name
PPP1R8, 1-351aa, Human, His tag, E Coli
Product Synonym Names
Nuclear inhibitor of protein phosphatase 1; ARD-1; ARD1; NIPP-1; NIPP1; PRO2047
Sequence
MAAAANSGSS LPLFDCPTWA GKPPPGLHLD VVKGDKLIEK LIIDEKKYYL FGRNPDLCDF TIDHQSCSRV HAALVYHKHL KRVFLIDLNS THGTFLGHIR LEPHKPQQIP IDSTVSFGAS TRAYTLREKP QTLPSAVKGD EKMGGEDDEL KGLLGLPEEE TELDNLTEFN TAHNKRISTL TIEEGNLDIQ RPKRKRKNSR VTFSEDDEII NPEDVDPSVG RFRNMVQTAV VPVKKKRVEG PGSLGLEESG SRRMQNFAFS GGLYGGLPPT HSEAGSQPHG IHGTALIGGL PMPYPNLAPD VDLTPVVPSA VNMNPAPNPA VYNPEAVNEP KKKKYAKEAW PGKKPTPSLL IVEHHHHHH
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol, 2mM DTT
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
39.5 kDa (359aa), confirmed by MALDI-TOF
OMIM
U14575 mRNA
3D Structure
ModBase 3D Structure for Q12972
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for PPP1R8 recombinant protein

Applications Tested/Suitable for PPP1R8 recombinant protein
SDS-PAGE

Product References and Citations for PPP1R8 recombinant protein

Jin Q., et al. (1999) Biochem. J. 342:13-19; Beullens M., et al. (2000) Biochem. J. 352:651-658

Other Notes

Small volumes of PPP1R8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP1R8 purchase

MBS204250 is a recombinant protein targeting PPP1R8. Also known as PPP1R8, 1-351aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP1R8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
nuclear inhibitor of protein phosphatase 1 isoform alpha
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory subunit 8
NCBI Official Symbol
PPP1R8
NCBI Official Synonym Symbols
ARD1; ARD-1; NIPP1; NIPP-1; PRO2047
UniProt Protein Name
Nuclear inhibitor of protein phosphatase 1
UniProt Synonym Protein Names
Protein phosphatase 1 regulatory inhibitor subunit 8Including the following 1 domains:Activator of RNA decay (EC:3.1.4.-)Alternative name(s):ARD-1
UniProt Gene Name
PPP1R8
UniProt Synonym Gene Names
ARD1; NIPP1; NIPP-1
NCBI Protein Information
nuclear inhibitor of protein phosphatase 1

NCBI Summary for PPP1R8

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for PPP1R8

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000