ATF3 Recombinant Protein

Name: ATF3 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204291
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204291

ATF3 (activating transcription factor 3) is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This protein binds the cAMP response element (CRE) (consensus:… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ATF3, Recombinant Protein

Full Product Name

ATF3, 1-181aa, Human, E Coli (Denatured)

Product Gene Name

ATF3 recombinant protein

Product Synonym Names

Activating transcription factor 3; ATF3deltaZip2; ATF3deltaZip2c; ATF3deltaZip3; cAMP dependent transcription factor ATF3; Cyclic AMP dependent transcription factor ATF3; Cyclic AMP-dependent transcription factor ATF-3

Sequence

MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl, pH8.0, 2M urea, 20%glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

20.6kDa (181aa)

OMIM

L19871 mRNA

3D Structure

ModBase 3D Structure for P18847

Antigen Species

Human

Product Categories/Family for ATF3 recombinant protein

Signal Transduction

Applications Tested/Suitable for ATF3 recombinant protein

SDS-PAGE

Application Notes for ATF3 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for ATF3 recombinant protein

Lv D., et al. (2011) IuBMB Life. 63 (1):62-9. ; Chen BP., et al. (1994) J Biol Chem 269 (22): 15819-26.

Other Notes

Small volumes of ATF3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATF3 purchase

MBS204291 is a recombinant protein targeting ATF3. Also known as ATF3, 1-181aa, Human, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ATF3. It may not necessarily be applicable to this product.

NCBI GI #

4502263

NCBI GeneID

467

NCBI Accession #

NP_001665

UniProt Primary Accession #

P18847

UniProt Secondary Accession #

Q5VTZ2; Q6ICQ9; Q7Z566; Q8WYM6

UniProt Related Accession #

P18847

GenBank Nucleotide #

NM_001674.3

NCBI Official Full Name

cyclic AMP-dependent transcription factor ATF-3 isoform 1

NCBI Official Synonym Full Names

activating transcription factor 3

NCBI Official Symbol

ATF3

UniProt Protein Name

Cyclic AMP-dependent transcription factor ATF-3

UniProt Synonym Protein Names

Activating transcription factor 3

Protein Family

Activating transcription factor

UniProt Gene Name

ATF3

UniProt Synonym Gene Names

cAMP-dependent transcription factor ATF-3

NCBI Protein Information

cyclic AMP-dependent transcription factor ATF-3

NCBI Summary for ATF3

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

UniProt Comments for ATF3

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

Research Articles on ATF3

1. ATF3 is a negative regulator of inflammation in human fetal membranes; in primary amnion cells, ATF3 expression is induced by IL-1beta and fsl-1, and ATF3 silencing further exacerbates the inflammatory response when stimulated with these factors. Subsequently, ATF3 expression is decreased in fetal membranes after term labour and with preterm chorioamnionitis, conditions closely associated with inflammation and infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ATF3 recombinant protein

Reference Product	PubMed Publications
JUN recombinant protein	>257 publications with ATF3 and JUN
ATF4 recombinant protein	>95 publications with ATF3 and ATF4
DDIT3 recombinant protein	>81 publications with ATF3 and DDIT3
ATF2 recombinant protein	>32 publications with ATF3 and ATF2
TP53 recombinant protein	>28 publications with ATF3 and TP53
JUNB recombinant protein	>22 publications with ATF3 and JUNB
JUND recombinant protein	>11 publications with ATF3 and JUND
SMAD3 recombinant protein	>7 publications with ATF3 and SMAD3
CREB1 recombinant protein	>4 publications with ATF3 and CREB1
IFNG recombinant protein	>3 publications with ATF3 and IFNG

Pathways associated with ATF3 recombinant protein

Products by Pathway	Pathway Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
ATF4 Activates Genes Pathway antibodies	ATF4 Activates Genes Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
PERK Regulates Gene Expression Pathway antibodies	PERK Regulates Gene Expression Pathway Diagram
Photodynamic Therapy-induced Unfolded Protein Response Pathway antibodies	Photodynamic Therapy-induced Unfolded Protein Response Pathway Diagram

Diseases associated with ATF3 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>195 publications with ATF3 and Nervous System Diseases
Disease Models, Animal Antibodies	>176 publications with ATF3 and Disease Models, Animal
Inflammation Antibodies	>165 publications with ATF3 and Inflammation
Peripheral Nervous System Diseases Antibodies	>103 publications with ATF3 and Peripheral Nervous System Diseases
Cardiovascular Diseases Antibodies	>88 publications with ATF3 and Cardiovascular Diseases
Necrosis Antibodies	>75 publications with ATF3 and Necrosis
Liver Diseases Antibodies	>42 publications with ATF3 and Liver Diseases
Heart Diseases Antibodies	>39 publications with ATF3 and Heart Diseases
Nerve Degeneration Antibodies	>31 publications with ATF3 and Nerve Degeneration
Hypertrophy Antibodies	>30 publications with ATF3 and Hypertrophy

Organs/Tissues associated with ATF3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>215 publications with ATF3 and Nerve
Ganglia Antibodies	>161 publications with ATF3 and Ganglia
Blood Antibodies	>138 publications with ATF3 and Blood
Brain Antibodies	>132 publications with ATF3 and Brain
Liver Antibodies	>91 publications with ATF3 and Liver
Muscle Antibodies	>91 publications with ATF3 and Muscle
Lung Antibodies	>69 publications with ATF3 and Lung
Bone Antibodies	>65 publications with ATF3 and Bone
Vascular Antibodies	>65 publications with ATF3 and Vascular
Skin Antibodies	>59 publications with ATF3 and Skin