DENR Recombinant Protein

Name: DENR Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204337
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204337

DENR may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. This protein plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DENR, Recombinant Protein

Full Product Name

DENR, 1-198aa, Human, His tag, E Coli

Product Gene Name

DENR recombinant protein

Product Synonym Names

Density-regulated protein; DRP; DRP1; SMAP-3

Sequence

MGSSHHHHHH SSGLVPRGSH MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 2mM DTT, 0.15M NaCl.

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

24.3 kDa (218aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

OMIM

AF038554 mRNA

3D Structure

ModBase 3D Structure for O43583

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for DENR recombinant protein

Signal Transduction

Applications Tested/Suitable for DENR recombinant protein

SDS-PAGE

Product References and Citations for DENR recombinant protein

Deyo JE., et al. (1998) DNA Cell Biol. 17 (5):437-47.; Oh JJ., et al. (1999) Nucleic Acids Res. 27 (20):4008-17.

Other Notes

Small volumes of DENR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DENR purchase

MBS204337 is a recombinant protein targeting DENR. Also known as DENR, 1-198aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DENR. It may not necessarily be applicable to this product.

NCBI GI #

27501446

NCBI GeneID

8562

NCBI Accession #

NP_003668

UniProt Primary Accession #

O43583

UniProt Secondary Accession #

Q9H3U6; Q9UKZ0

UniProt Related Accession #

O43583

GenBank Nucleotide #

NM_003677.4

NCBI Official Full Name

density-regulated protein

NCBI Official Synonym Full Names

density regulated re-initiation and release factor

NCBI Official Symbol

DENR

NCBI Official Synonym Symbols

DRP; DRP1; SMAP-3

UniProt Protein Name

Density-regulated protein

UniProt Synonym Protein Names

Protein DRP1; Smooth muscle cell-associated protein 3; SMAP-3

Protein Family

Density-regulated protein

UniProt Gene Name

DENR

UniProt Synonym Gene Names

DRP1; DRP; SMAP-3

NCBI Protein Information

density-regulated protein

NCBI Summary for DENR

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

UniProt Comments for DENR

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

Research Articles on DENR

1. DENR binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interfere with eIF1/eIF2/eIF3 binding, thus operating in ribosome recycling and translation re-initiation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DENR recombinant protein

Reference Product	PubMed Publications
MCTS1 recombinant protein	>8 publications with DENR and MCTS1

Diseases associated with DENR recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2 publications with DENR and Nervous System Diseases
Brain Diseases Antibodies	>2 publications with DENR and Brain Diseases
Hepatitis Antibodies	>1 publications with DENR and Hepatitis
Neoplasm Metastasis Antibodies	>1 publications with DENR and Neoplasm Metastasis
Disease Models, Animal Antibodies	>1 publications with DENR and Disease Models, Animal
Cell Transformation, Neoplastic Antibodies	>1 publications with DENR and Cell Transformation, Neoplastic

Organs/Tissues associated with DENR recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with DENR and Brain
Nerve Antibodies	>1 publications with DENR and Nerve
Liver Antibodies	>1 publications with DENR and Liver
Muscle Antibodies	>1 publications with DENR and Muscle
Embryonic Tissue Antibodies	>1 publications with DENR and Embryonic Tissue