SARS Recombinant Protein

Name: SARS Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204547
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204547

SARS (Seryl-tRNA synthetase, cytoplasmic) belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SARS, Recombinant Protein

Full Product Name

SARS, 1-514aa, Human, His tag, E Coli

Product Gene Name

SARS recombinant protein

Product Synonym Names

Seryl-tRNA synthetase; SERRS; SERS

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMVLDLDL FRVDKGGDPA LIRETQEKRF KDPGLVDQLV KADSEWRRCR FRADNLNKLK NLCSKTIGEK MKKKEPVGDD ESVPENVLSF DDLTADALAN LKVSQIKKVR LLIDEAILKC DAERIKLEAE RFENLREIGN LLHPSVPISN DEDVDNKVER IWGDCTVRKK YSHVDLVVMV DGFEGEKGAV VAGSRGYFLK GVLVFLEQAL IQYALRTLGS RGYIPIYTPF FMRKEVMQEV AQLSQFDEEL YKVIGKGSEK SDDNSYDEKY LIATSEQPIA ALHRDEWLRP EDLPIKYAGL STCFRQEVGS HGRDTRGIFR VHQFEKIEQF VYSSPHDNKS WEMFEEMITT AEEFYQSLGI PYHIVNIVSG SLNHAASKKL DLEAWFPGSG AFRELVSCSN CTDYQARRLR IRYGQTKKMM DKVEFVHMLN ATMCATTRTI CAILENYQTE KGITVPEKLK EFMPPGLQEL IPFVKPAPIE QEPSKKQKKQ HEGSKKKAAA RDVTLENRLQ NMEVTDA

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 100mM NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

61.2kDa (537aa)

OMIM

X91257 mRNA

3D Structure

ModBase 3D Structure for P49591

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for SARS recombinant protein

Metabolism

Applications Tested/Suitable for SARS recombinant protein

SDS-PAGE

Product References and Citations for SARS recombinant protein

Hartlein M, et al. (1995) J. Mol. Evol. 40 (5): 519-30.; Vincent C., et al. (1997) Eur. J. Biochem. 250:77-84

Other Notes

Small volumes of SARS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SARS purchase

MBS204547 is a recombinant protein targeting SARS. Also known as SARS, 1-514aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SARS. It may not necessarily be applicable to this product.

NCBI GI #

16306548

NCBI GeneID

6301

NCBI Accession #

NP_006504

UniProt Primary Accession #

P49591

UniProt Secondary Accession #

Q5T5C8; Q9NSE3; B2R6Y9

UniProt Related Accession #

P49591

GenBank Nucleotide #

NM_006513.3

NCBI Official Full Name

serine--tRNA ligase, cytoplasmic isoform a

NCBI Official Synonym Full Names

seryl-tRNA synthetase

NCBI Official Symbol

SARS

NCBI Official Synonym Symbols

SERS; SERRS; NEDMAS

UniProt Protein Name

Serine--tRNA ligase, cytoplasmic

UniProt Synonym Protein Names

Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Protein Family

HTH-type transcriptional regulator

UniProt Gene Name

SARS

UniProt Synonym Gene Names

SERS; SerRS

NCBI Protein Information

serine--tRNA ligase, cytoplasmic

NCBI Summary for SARS

This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

UniProt Comments for SARS

Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).

Research Articles on SARS

1. Analyzed the ability of cytosolic SerRS to bind and act on tRNA(Ser), tRNA(Sec), and 10 mutant and chimeric constructs in which elements of tRNA(Ser) were transposed onto tRNA(Sec). We show that SerRS only subtly prefers tRNA(Ser) to tRNA(Sec), and that discrimination occurs at the level of the serylation reaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SARS recombinant protein

Reference Product	PubMed Publications
MARS recombinant protein	>33 publications with SARS and MARS
CAD recombinant protein	>4 publications with SARS and CAD
SARS2 recombinant protein	>1 publications with SARS and SARS2
TARS recombinant protein	>1 publications with SARS and TARS
GARS recombinant protein	>1 publications with SARS and GARS

Pathways associated with SARS recombinant protein

Products by Pathway	Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Cytosolic TRNA Aminoacylation Pathway antibodies	Cytosolic TRNA Aminoacylation Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Selenium Metabolism And Selenoproteins Pathway antibodies	Selenium Metabolism And Selenoproteins Pathway Diagram
Selenoamino Acid Metabolism Pathway antibodies	Selenoamino Acid Metabolism Pathway Diagram

Diseases associated with SARS recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>205 publications with SARS and Disease Models, Animal
Inflammation Antibodies	>143 publications with SARS and Inflammation
Necrosis Antibodies	>129 publications with SARS and Necrosis
Liver Diseases Antibodies	>82 publications with SARS and Liver Diseases
Brain Diseases Antibodies	>69 publications with SARS and Brain Diseases
Fibrosis Antibodies	>66 publications with SARS and Fibrosis
Pain Antibodies	>55 publications with SARS and Pain
Edema Antibodies	>46 publications with SARS and Edema
Heart Diseases Antibodies	>44 publications with SARS and Heart Diseases
Kidney Diseases Antibodies	>42 publications with SARS and Kidney Diseases

Organs/Tissues associated with SARS recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>979 publications with SARS and Blood
Lung Antibodies	>683 publications with SARS and Lung
Brain Antibodies	>168 publications with SARS and Brain
Liver Antibodies	>142 publications with SARS and Liver
Muscle Antibodies	>122 publications with SARS and Muscle
Nerve Antibodies	>118 publications with SARS and Nerve
Kidney Antibodies	>118 publications with SARS and Kidney
Heart Antibodies	>113 publications with SARS and Heart
Skin Antibodies	>93 publications with SARS and Skin
Bone Antibodies	>79 publications with SARS and Bone