ADRM1 Recombinant Protein

Name: ADRM1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204638
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204638

ADRM1, also known as proteasomal ubiquitin receptor ADRM1, functions as a proteasomal ubiquitin receptor. This protein is an integral plasma membrane protein which promotes cell adhesion. ADRM1 is thought to undergo O-linked glycosylation. Expression of this… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ADRM1, Recombinant Protein

Full Product Name

ADRM1, 1-407aa, Human, His tag, E Coli

Product Gene Name

ADRM1 recombinant protein

Product Synonym Names

Proteasomal ubiquitin receptor ADRM1; ARM1; GP110; Rpn13

Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTTSGA LFPSLVPGSR GASNKYLVEF RAGKMSLKGT TVTPDKRKGL VYIQQTDDSL IHFCWKDRTS GNVEDDLIIF PDDCEFKRVP QCPSGRVYVL KFKAGSKRLF FWMQEPKTDQ DEEHCRKVNE YLNNPPMPGA LGASGSSGHE LSALGGEGGL QSLLGNMSHS QLMQLIGPAG LGGLGGLGAL TGPGLASLLG SSGPPGSSSS SSSRSQSAAV TPSSTTSSTR ATPAPSAPAA ASATSPSPAP SSGNGASTAA SPTQPIQLSD LQSILATMNV PAGPAGGQQV DLASVLTPEI MAPILANADV QERLLPYLPS GESLPQTADE IQNTLTSPQF QQALGMFSAA LASGQLGPLM CQFGLPAEAV EAANKGDVEA FAKAMQNNAK PEQKEGDTKD KKDEEEDMSL D

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT

Purity/Purification

> 85% by SDS-PAGE

Concentration

1mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

44.7 kDa (431aa) confirmed by MALDI-TOF

OMIM

D64154 mRNA

3D Structure

ModBase 3D Structure for Q16186

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for ADRM1 recombinant protein

Cytoskeleton

Applications Tested/Suitable for ADRM1 recombinant protein

SDS-PAGE

Product References and Citations for ADRM1 recombinant protein

Hamazaki J., et al. (2006) EMBO J. 25:4524-4536; Qiu X.-B., et al. (2006) EMBO J. 25:5742-5753

Other Notes

Small volumes of ADRM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADRM1 purchase

MBS204638 is a recombinant protein targeting ADRM1. Also known as ADRM1, 1-407aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ADRM1. It may not necessarily be applicable to this product.

NCBI GI #

28373194

NCBI GeneID

11047

NCBI Accession #

NP_783163

UniProt Primary Accession #

Q16186

UniProt Secondary Accession #

Q96FJ7; Q9H1P2; A0PKB1

UniProt Related Accession #

Q16186

GenBank Nucleotide #

NM_175573.2

NCBI Official Full Name

proteasomal ubiquitin receptor ADRM1 isoform 1

NCBI Official Synonym Full Names

adhesion regulating molecule 1

NCBI Official Symbol

ADRM1

NCBI Official Synonym Symbols

ARM1; ARM-1; GP110

UniProt Protein Name

Proteasomal ubiquitin receptor ADRM1

UniProt Synonym Protein Names

110 kDa cell membrane glycoprotein; Gp110; Adhesion-regulating molecule 1; ARM-1; Proteasome regulatory particle non-ATPase 13; hRpn13; Rpn13 homolog

Protein Family

Proteasomal ubiquitin receptor

UniProt Gene Name

ADRM1

UniProt Synonym Gene Names

GP110; Gp110; ARM-1; hRpn13

NCBI Protein Information

proteasomal ubiquitin receptor ADRM1

NCBI Summary for ADRM1

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for ADRM1

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.

Research Articles on ADRM1

1. The structures of proteasome substrate receptor complexes with the shuttle factors that deliver ubiquitinated proteins to proteasomes have been solved, namely human Rpn13 complexed with PLIC2 and Saccharomyces cerevisiae Rpn1 with Rad23.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ADRM1 recombinant protein

Reference Product	PubMed Publications
UCHL5 recombinant protein	>18 publications with ADRM1 and UCHL5
PSMD4 recombinant protein	>7 publications with ADRM1 and PSMD4
PSMD2 recombinant protein	>1 publications with ADRM1 and PSMD2

Pathways associated with ADRM1 recombinant protein

Products by Pathway	Pathway Diagram
Deubiquitination Pathway antibodies	Deubiquitination Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Proteasome Pathway antibodies	Proteasome Pathway Diagram
Proteasome Pathway antibodies	Proteasome Pathway Diagram
Proteasome, 19S Regulatory Particle (PA700) Pathway antibodies	Proteasome, 19S Regulatory Particle (PA700) Pathway Diagram
Proteasome, 19S Regulatory Particle (PA700) Pathway antibodies	Proteasome, 19S Regulatory Particle (PA700) Pathway Diagram
UCH Proteinases Pathway antibodies	UCH Proteinases Pathway Diagram

Diseases associated with ADRM1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms, Experimental Antibodies	>2 publications with ADRM1 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>2 publications with ADRM1 and Lung Neoplasms
Breast Neoplasms Antibodies	>2 publications with ADRM1 and Breast Neoplasms
Inflammation Antibodies	>2 publications with ADRM1 and Inflammation
Carcinoma, Hepatocellular Antibodies	>1 publications with ADRM1 and Carcinoma, Hepatocellular
Nervous System Diseases Antibodies	>1 publications with ADRM1 and Nervous System Diseases
Cell Transformation, Neoplastic Antibodies	>1 publications with ADRM1 and Cell Transformation, Neoplastic
Liver Diseases Antibodies	>1 publications with ADRM1 and Liver Diseases

Organs/Tissues associated with ADRM1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Ovary Antibodies	>4 publications with ADRM1 and Ovary
Liver Antibodies	>3 publications with ADRM1 and Liver
Bone Antibodies	>3 publications with ADRM1 and Bone
Blood Antibodies	>3 publications with ADRM1 and Blood
Brain Antibodies	>3 publications with ADRM1 and Brain
Kidney Antibodies	>2 publications with ADRM1 and Kidney
Lung Antibodies	>2 publications with ADRM1 and Lung
Vascular Antibodies	>2 publications with ADRM1 and Vascular
Lymph Antibodies	>2 publications with ADRM1 and Lymph
Stomach Antibodies	>2 publications with ADRM1 and Stomach