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KLRC3 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204658

KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KLRC3, Recombinant Protein
Full Product Name
KLRC3, 94-240aa, Human, His tag, E Coli (Denatured)
Product Gene Name
KLRC3 recombinant protein
Product Synonym Names
Killer cell lectin-like receptor subfamily C; NKG2-E; NKG2E
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMIPFLEQ NNSSPNTRTQ KARPCGHCPE EWITYSNSCY YIGKERRTWE ESLQACASKN SSSLLSIDNE EEMKFLASIL PSSWIGVFRN SSHHPWVTIN GLAFKHEIKD SDHAERNCAM LHVRGLISDQ CGSSRIIRRG FIMLTRLVLN S
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M NaCl, 10% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
19 kDa (171aa)
OMIM
L14542 mRNA
3D Structure
ModBase 3D Structure for Q07444
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for KLRC3 recombinant protein

Immunology
Applications Tested/Suitable for KLRC3 recombinant protein
SDS-PAGE
Application Notes for KLRC3 recombinant protein
This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

SDS-Page of KLRC3 recombinant protein

KLRC3 Recombinant Protein – Cat# MBS204658

Product References and Citations for KLRC3 recombinant protein

Plougastel B, et al. (1998). Genomics. 15;49 (2):193-9.; Shum BP., et al. (2002). J Immunol. 1;168 (1):240-52.

Other Notes

Small volumes of KLRC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLRC3 purchase

MBS204658 is a recombinant protein targeting KLRC3. Also known as KLRC3, 94-240aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for KLRC3. It may not necessarily be applicable to this product.

NCBI GI #
75709175
NCBI GeneID
3823
NCBI Accession #
NP_002252
UniProt Primary Accession #
Q07444
UniProt Secondary Accession #
Q8WXA4; Q96RL0; Q9UP04
UniProt Related Accession #
Q07444
GenBank Nucleotide #
NM_002261.2
NCBI Official Full Name
NKG2-E type II integral membrane protein isoform E
NCBI Official Synonym Full Names
killer cell lectin like receptor C3
NCBI Official Symbol
KLRC3
NCBI Official Synonym Symbols
NKG2E; NKG2-E
UniProt Protein Name
NKG2-E type II integral membrane protein
UniProt Synonym Protein Names
NK cell receptor E; NKG2-E-activating NK receptor
Protein Family
NKG2-E type II integral membrane protein
UniProt Gene Name
KLRC3
UniProt Synonym Gene Names
NKG2E
NCBI Protein Information
NKG2-E type II integral membrane protein

NCBI Summary for KLRC3

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for KLRC3

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Research Articles on KLRC3

1. KLRC3 gene expression is linked to glioblastoma aggressiveness.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KLRC3 recombinant protein

 Reference Product  PubMed Publications
 KLRC2 recombinant protein  >26 publications with KLRC3 and KLRC2
 KLRD1 recombinant protein  >19 publications with KLRC3 and KLRD1
 NKG2-E recombinant protein  >5 publications with KLRC3 and NKG2-E
 KLRB1 recombinant protein  >3 publications with KLRC3 and KLRB1
 HLA-E recombinant protein  >3 publications with KLRC3 and HLA-E
 TYROBP recombinant protein  >2 publications with KLRC3 and TYROBP

Pathways associated with KLRC3 recombinant protein

 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with KLRC3 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with KLRC3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with KLRC3 and Cardiovascular Diseases
 Demyelinating Diseases Antibodies  >1 publications with KLRC3 and Demyelinating Diseases
 Disease Models, Animal Antibodies  >1 publications with KLRC3 and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with KLRC3 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with KLRC3 and Inflammation
 Thrombosis Antibodies  >1 publications with KLRC3 and Thrombosis
 Eye Diseases Antibodies  >1 publications with KLRC3 and Eye Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1 publications with KLRC3 and Encephalomyelitis, Autoimmune, Experimental
 Lung Diseases Antibodies  >1 publications with KLRC3 and Lung Diseases

Organs/Tissues associated with KLRC3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with KLRC3 and Kidney
 Brain Antibodies  >1 publications with KLRC3 and Brain
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