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PINK1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204731

PINK1 is a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this protein cause one form of autosomal recessive early-onset Parkinson disease. Recombinant… More details

$230 / 0.02 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PINK1, Recombinant Protein
Full Product Name
PINK1, 156-507aa, Human, E Coli (Denatured)
Product Gene Name
PINK1 recombinant protein
Product Synonym Names
Serine/threonine-protein kinase PINK1 mitochondrial; Serine/threonine-protein kinase PINK1; mitochondrial; BRPK; FLJ27236; PARK6
Sequence
MYLIGQSIGK GCSAAVYEAT MPTLPQNLEV TKSTGLLPGR GPGTSAPGEG QERAPGAPAF PLAIKMMWNI SAGSSSEAIL NTMSQELVPA SRVALAGEYG AVTYRKSKRG PKQLAPHPNI IRVLRAFTSS VPLLPGALVD YPDVLPSRLH PEGLGHGRTL FLVMKNYPCT LRQYLCVNTP SPRLAAMMLL QLLEGVDHLV QQGIAHRDLK SDNILVELDP DGCPWLVIAD FGCCLADESI GLQLPFSSWY VDRGGNGCLM APEVSTARPG PRAVIDYSKA DAWAVGAIAY EIFGLVNPFY GQGKAHLESR SYQEAQLPAL PESVPPDVRQ LVRALLQREA SKRPSARVAA NVL
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) 1M urea, 5% glycerol.
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
37.9 kDa (353aa)
OMIM
AB053323 mRNA
Antigen Species
Human

Product Categories/Family for PINK1 recombinant protein

Neuroscience
Applications Tested/Suitable for PINK1 recombinant protein
SDS-PAGE
Application Notes for PINK1 recombinant protein
This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

SDS-Page of PINK1 recombinant protein

PINK1 Recombinant Protein – Cat# MBS204731

Product References and Citations for PINK1 recombinant protein

Valente EM., et al. (2004) Ann Neurol. 56 (3):336-41.; unoki M., et al. (2001) Oncogene. 20 (33):4457-65.

Other Notes

Small volumes of PINK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PINK1 purchase

MBS204731 is a recombinant protein targeting PINK1. Also known as PINK1, 156-507aa, Human, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PINK1. It may not necessarily be applicable to this product.

NCBI GI #
20381329
NCBI GeneID
65018
NCBI Accession #
AAH28215
UniProt Secondary Accession #
Q8N6T9; Q8NBU3; Q96DE4
UniProt Related Accession #
Q9BXM7
NCBI Official Full Name
PTEN induced putative kinase 1
NCBI Official Synonym Full Names
PTEN induced putative kinase 1
NCBI Official Symbol
PINK1
NCBI Official Synonym Symbols
BRPK; PARK6
UniProt Protein Name
Serine/threonine-protein kinase PINK1, mitochondrial
UniProt Synonym Protein Names
BRPK; PTEN-induced putative kinase protein 1
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
PINK1
NCBI Protein Information
serine/threonine-protein kinase PINK1, mitochondrial

NCBI Summary for PINK1

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

UniProt Comments for PINK1

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 ().
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Research Articles on PINK1

1. Here we review the evidence supporting PINK1/Parkin mitophagy in vivo and its causative role in neurodegeneration, and outline outstanding questions for future investigations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PINK1 recombinant protein

 Reference Product  PubMed Publications
 PARK2 recombinant protein  >744 publications with PINK1 and PARK2
 PARK7 recombinant protein  >135 publications with PINK1 and PARK7
 MFN2 recombinant protein  >45 publications with PINK1 and MFN2
 SQSTM1 recombinant protein  >26 publications with PINK1 and SQSTM1
 MFN1 recombinant protein  >21 publications with PINK1 and MFN1
 VDAC1 recombinant protein  >9 publications with PINK1 and VDAC1
 TOMM20 recombinant protein  >8 publications with PINK1 and TOMM20
 TOMM40 recombinant protein  >6 publications with PINK1 and TOMM40
 TOMM70A recombinant protein  >3 publications with PINK1 and TOMM70A

Pathways associated with PINK1 recombinant protein

 Products by Pathway  Pathway Diagram
 Mitophagy Pathway antibodies  Mitophagy Pathway Diagram
 Mitophagy - Animal Pathway antibodies  Mitophagy - Animal Pathway Diagram
 Mitophagy - Animal Pathway antibodies  Mitophagy - Animal Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Pink/Parkin Mediated Mitophagy Pathway antibodies  Pink/Parkin Mediated Mitophagy Pathway Diagram

Diseases associated with PINK1 recombinant protein

 Disease Name  Pubmed Publications
 Parkinson Disease Antibodies  >731 publications with PINK1 and Parkinson Disease
 Movement Disorders Antibodies  >689 publications with PINK1 and Movement Disorders
 Parkinsonian Disorders Antibodies  >673 publications with PINK1 and Parkinsonian Disorders
 Death Antibodies  >238 publications with PINK1 and Death
 Disease Models, Animal Antibodies  >154 publications with PINK1 and Disease Models, Animal
 Inflammation Antibodies  >42 publications with PINK1 and Inflammation
 Nerve Degeneration Antibodies  >36 publications with PINK1 and Nerve Degeneration
 Neuroblastoma Antibodies  >33 publications with PINK1 and Neuroblastoma
 Tremor Antibodies  >27 publications with PINK1 and Tremor
 Necrosis Antibodies  >26 publications with PINK1 and Necrosis

Organs/Tissues associated with PINK1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >333 publications with PINK1 and Brain
 Muscle Antibodies  >103 publications with PINK1 and Muscle
 Nerve Antibodies  >79 publications with PINK1 and Nerve
 Blood Antibodies  >49 publications with PINK1 and Blood
 Heart Antibodies  >48 publications with PINK1 and Heart
 Lung Antibodies  >29 publications with PINK1 and Lung
 Liver Antibodies  >28 publications with PINK1 and Liver
 Eye Antibodies  >22 publications with PINK1 and Eye
 Kidney Antibodies  >21 publications with PINK1 and Kidney
 Vascular Antibodies  >14 publications with PINK1 and Vascular
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