GMPS Recombinant Protein

Name: GMPS Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204738
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204738

GMP synthase, also known as GMPS, is involved in purine biosynthesis. Existing as a homodimer, GMPS catalyzes the last step in the GMP synthesis pathway, namely the ATP-dependent amination of XMP to GMP. GMPS contains one GMP-binding domain and one glutamine… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GMPS, Recombinant Protein

Full Product Name

GMPS, 1-693aa, Human, His tag, E Coli

Product Gene Name

GMPS recombinant protein

Product Synonym Names

GMP synthase [glutamine-hydrolyzing]; Glutamine amidotransferase; guanine monophosphate synthetase

Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMALCNG DSKLENAGGD LKDGHHHYEG AVVILDAGAQ YGKVIDRRVR ELFVQSEIFP LETPAFAIKE QGFRAIIISG GPNSVYAEDA PWFDPAIFTI GKPVLGICYG MQMMNKVFGG TVHKKSVRED GVFNISVDNT CSLFRGLQKE EVVLLTHGDS VDKVADGFKV VARSGNIVAG IANESKKLYG AQFHPEVGLT ENGKVILKNF LYDIAGCSGT FTVQNRELEC IREIKERVGT SKVLVLLSGG VDSTVCTALL NRALNQEQVI AVHIDNGFMR KRESQSVEEA LKKLGIQVKV INAAHSFYNG TTTLPISDED RTPRKRISKT LNMTTSPEEK RKIIGDTFVK IANEVIGEMN LKPEEVFLAQ GTLRPDLIES ASLVASGKAE LIKTHHNDTE LIRKLREEGK VIEPLKDFHK DEVRILGREL GLPEELVSRH PFPGPGLAIR VICAEEPYIC KDFPETNNIL KIVADFSASV KKPHTLLQRV KACTTEEDQE KLMQITSLHS LNAFLLPIKT VGVQGDCRSY SYVCGISSKD EPDWESLIFL ARLIPRMCHN VNRVVYIFGP PVKEPPTDVT PTFLTTGVLS TLRQADFEAH NILRESGYAG KISQMPVILT PLHFDRDPLQ KQPSCQRSVV IRTFITSDFM TGIPATPGNE IPVEVVLKMV TEIKKIPGIS RIMYDLTSKP PGTTEWE

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

79.2 kDa (717aa)

OMIM

U10860 mRNA

3D Structure

ModBase 3D Structure for P49915

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for GMPS recombinant protein

Metabolism

Applications Tested/Suitable for GMPS recombinant protein

SDS-PAGE

Product References and Citations for GMPS recombinant protein

Hirst M., et al. (1994) J Biol Chem. 269:23830-23837.; Nakamura J., et al. (1995) J Biol Chem. 270:23450-23455.

Other Notes

Small volumes of GMPS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GMPS purchase

MBS204738 is a recombinant protein targeting GMPS. Also known as GMPS, 1-693aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GMPS. It may not necessarily be applicable to this product.

NCBI GI #

4504035

NCBI GeneID

8833

NCBI Accession #

NP_003866

UniProt Primary Accession #

P49915

UniProt Secondary Accession #

A8K639; B4DXV7; F8W720

UniProt Related Accession #

P49915

GenBank Nucleotide #

NM_003875.2

NCBI Official Full Name

GMP synthase

NCBI Official Synonym Full Names

guanine monophosphate synthase

NCBI Official Symbol

GMPS

NCBI Official Synonym Symbols

GATD7

UniProt Protein Name

GMP synthase [glutamine-hydrolyzing]

UniProt Synonym Protein Names

GMP synthetase; Glutamine amidotransferase

UniProt Gene Name

GMPS

NCBI Protein Information

GMP synthase [glutamine-hydrolyzing]

NCBI Summary for GMPS

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

UniProt Comments for GMPS

Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

Research Articles on GMPS

1. Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GMPS recombinant protein

Reference Product	PubMed Publications
IMPDH1 recombinant protein	>1 publications with GMPS and IMPDH1
IMPDH2 recombinant protein	>1 publications with GMPS and IMPDH2

Pathways associated with GMPS recombinant protein

Products by Pathway	Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies	Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies	Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram

Diseases associated with GMPS recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>31 publications with GMPS and Heart Diseases
Inflammation Antibodies	>11 publications with GMPS and Inflammation
Cell Transformation, Neoplastic Antibodies	>9 publications with GMPS and Cell Transformation, Neoplastic
Anemia Antibodies	>7 publications with GMPS and Anemia
Adenocarcinoma Antibodies	>4 publications with GMPS and Adenocarcinoma
Kidney Diseases Antibodies	>3 publications with GMPS and Kidney Diseases
Neoplasms, Experimental Antibodies	>3 publications with GMPS and Neoplasms, Experimental
Carcinoma, Hepatocellular Antibodies	>2 publications with GMPS and Carcinoma, Hepatocellular
Genital Diseases, Female Antibodies	>2 publications with GMPS and Genital Diseases, Female
Precancerous Conditions Antibodies	>2 publications with GMPS and Precancerous Conditions

Organs/Tissues associated with GMPS recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>95 publications with GMPS and Blood
Bone Marrow Antibodies	>49 publications with GMPS and Bone Marrow
Heart Antibodies	>27 publications with GMPS and Heart
Vascular Antibodies	>23 publications with GMPS and Vascular
Muscle Antibodies	>14 publications with GMPS and Muscle
Liver Antibodies	>12 publications with GMPS and Liver
Mouth Antibodies	>11 publications with GMPS and Mouth
Spleen Antibodies	>9 publications with GMPS and Spleen
Connective Tissue Antibodies	>8 publications with GMPS and Connective Tissue
Lung Antibodies	>6 publications with GMPS and Lung