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BPIFA1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204992

BPIFA1, also known as PLuNC, belongs to the short subfamily of PLuNC family proteins and have homology only to the Nterminal domains of BPI. It is a secreted protein that is expressed in the secretory ducts and submucosal glands of tracheobronchial tissues.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BPIFA1, Recombinant Protein
Full Product Name
BPIFA1, 20-256aa, Human, His tag, E Coli
Product Gene Name
BPIFA1 recombinant protein
Product Synonym Names
BPI fold-containing family A member 1; BPI fold-containing family A; member 1; bA49G10.5; LPLuNC3; LuNX; NASG; PLuNC; SPuRT
Sequence
MGSSHHHHHH SSGLVPRGSH MGSQFGGLPV PLDQTLPLNV NPALPLSPTG LAGSLTNALS NGLLSGGLLG ILENLPLLDI LKPGGGTSGG LLGGLLGKVT SVIPGLNNII DIKVTDPQLL ELGLVQSPDG HRLYVTIPLG IKLQVNTPLV GASLLRLAVK LDITAEILAV RDKQERIHLV LGDCTHSPGS LQISLLDGLG PLPIQGLLDS LTGILNKVLP ELVQGNVCPL VNEVLRGLDI TLVHDIVNML IHGLQFVIKV
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 30% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by BCA assay) (lot specific)
Preparation and Storage
Can be stored at 2-8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
Molecular Weight
27.1 kDa (260aa), confirmed by MALDI-TOF
OMIM
AF214562 Genomic DNA
3D Structure
ModBase 3D Structure for Q9NP55
Tag Information
His-tag

Product Categories/Family for BPIFA1 recombinant protein

Immunology
Applications Tested/Suitable for BPIFA1 recombinant protein
SDS-PAGE

SDS-Page of BPIFA1 recombinant protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
BPIFA1 Recombinant Protein – Cat# MBS204992

Product References and Citations for BPIFA1 recombinant protein

Ghafouri B., et al. (2004) Biochem Biophys Acta. 1699:57-63.; Bingle C D., et al. (2002) Hum Mol Genet. 11: 937-943.

Other Notes

Small volumes of BPIFA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BPIFA1 purchase

MBS204992 is a recombinant protein targeting BPIFA1. Also known as BPIFA1, 20-256aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BPIFA1. It may not necessarily be applicable to this product.

NCBI GI #
7706119
NCBI GeneID
51297
NCBI Accession #
NP_057667
UniProt Primary Accession #
Q9NP55
UniProt Secondary Accession #
Q9NZT0; A6XMV5; A8K9R3; E1P5M9
UniProt Related Accession #
Q9NP55
GenBank Nucleotide #
NM_016583.3
NCBI Official Full Name
BPI fold-containing family A member 1
NCBI Official Synonym Full Names
BPI fold containing family A member 1
NCBI Official Symbol
BPIFA1
NCBI Official Synonym Symbols
LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5
UniProt Protein Name
BPI fold-containing family A member 1
UniProt Synonym Protein Names
Lung-specific protein X; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; Secretory protein in upper respiratory tracts; Short PLUNC1; SPLUNC1; Tracheal epithelium-enriched protein; Von Ebner protein Hl
Protein Family
BPI fold-containing family
UniProt Gene Name
BPIFA1
UniProt Synonym Gene Names
LUNX; NASG; PLUNC; SPLUNC1; SPURT; SPLUNC1
NCBI Protein Information
BPI fold-containing family A member 1

NCBI Summary for BPIFA1

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]
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UniProt Comments for BPIFA1

Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.
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Research Articles on BPIFA1

1. SPLUNC1 has antimicrobial and antibiofilm activities against the Burkholderia cepacia complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BPIFA1 recombinant protein

 Reference Product  PubMed Publications
 BPI recombinant protein  >32 publications with BPIFA1 and BPI
 IL13 recombinant protein  >5 publications with BPIFA1 and IL13
 CETP recombinant protein  >3 publications with BPIFA1 and CETP
 TLR2 recombinant protein  >2 publications with BPIFA1 and TLR2
 PLTP recombinant protein  >2 publications with BPIFA1 and PLTP

Pathways associated with BPIFA1 recombinant protein

 Products by Pathway  Pathway Diagram
 Antimicrobial Peptides Pathway antibodies  Antimicrobial Peptides Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with BPIFA1 recombinant protein

 Disease Name  Pubmed Publications
 Respiratory Tract Diseases Antibodies  >66 publications with BPIFA1 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >51 publications with BPIFA1 and Lung Diseases
 Carcinoma Antibodies  >45 publications with BPIFA1 and Carcinoma
 Inflammation Antibodies  >34 publications with BPIFA1 and Inflammation
 Lung Neoplasms Antibodies  >28 publications with BPIFA1 and Lung Neoplasms
 Fibrosis Antibodies  >20 publications with BPIFA1 and Fibrosis
 Pulmonary Fibrosis Antibodies  >13 publications with BPIFA1 and Pulmonary Fibrosis
 Pneumonia Antibodies  >11 publications with BPIFA1 and Pneumonia
 Respiratory Hypersensitivity Antibodies  >5 publications with BPIFA1 and Respiratory Hypersensitivity
 Necrosis Antibodies  >5 publications with BPIFA1 and Necrosis

Organs/Tissues associated with BPIFA1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >117 publications with BPIFA1 and Lung
 Pharynx Antibodies  >11 publications with BPIFA1 and Pharynx
 Trachea Antibodies  >9 publications with BPIFA1 and Trachea
 Larynx Antibodies  >3 publications with BPIFA1 and Larynx
 Muscle Antibodies  >2 publications with BPIFA1 and Muscle
 Connective Tissue Antibodies  >1 publications with BPIFA1 and Connective Tissue
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