BAD92605.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,261 Da
NCBI Official Full Name
protein tyrosine phosphatase, receptor type, N variant, partial
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type N
NCBI Official Synonym Symbols
IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP [Similar Products]
NCBI Protein Information
receptor-type tyrosine-protein phosphatase-like N
UniProt Protein Name
Receptor-type tyrosine-protein phosphatase-like N
UniProt Synonym Protein Names
Islet cell antigen 512
UniProt Synonym Gene Names
NCBI Summary for PTPRN
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
UniProt Comments for PTPRN
PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cell soma; endosome; Golgi apparatus; nerve terminal; nucleus; plasma membrane; secretory granule; synapse; synaptic vesicle
Molecular Function: protein binding; protein tyrosine phosphatase activity; spectrin binding; transcription factor binding
Biological Process: insulin secretion; luteinization; positive regulation of transcription from RNA polymerase II promoter; response to reactive oxygen species
Research Articles on PTPRN
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Products associated with anti-PTPRN antibody
Pathways associated with anti-PTPRN antibody
Diseases associated with anti-PTPRN antibody
Organs/Tissues associated with anti-PTPRN antibody
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