XPA Recombinant Protein

Name: XPA Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205019
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205019

XPA, also known as DNA repair protein complementing XP-A cells, belong to the XPA family. This protein is involved in DNA excision repair. It Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

XPA, Recombinant Protein

Full Product Name

XPA, 1-273aa, Human, His tag, E Coli (Denatured)

Product Gene Name

XPA recombinant protein

Product Synonym Names

DNA repair protein complementing XP-A cells; XP1; XPAC

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAAADGA LPEAAALEQP AELPASVRAS IERKRQRALM LRQARLAARP YSATAAAATG GMANVKAAPK IIDTGGGFIL EEEEEEEQKI GKVVHQPGPV MEFDYVICEE CGKEFMDSYL MNHFDLPTCD NCRDADDKHK LITKTEAKQE YLLKDCDLEK REPPLKFIVK KNPHHSQWGD MKLYLKLQIV KRSLEVWGSQ EALEEAKEVR QENREKMKQK KFDKKVKELR RAVRSSVWKR ETIVHQHEYG PEENLEDDMY RKTCTMCGHE LTYEKM

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

33.8 kDa (296aa)

OMIM

D14533 mRNA

3D Structure

ModBase 3D Structure for P23025

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for XPA recombinant protein

Epigenomics

Applications Tested/Suitable for XPA recombinant protein

SDS-PAGE

Application Notes for XPA recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for XPA recombinant protein

Pan Y.R., et al. (2009) Cell Cycle 8:655-664; James, et al. (2005) Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders.;

Other Notes

Small volumes of XPA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XPA purchase

MBS205019 is a recombinant protein targeting XPA. Also known as XPA, 1-273aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for XPA. It may not necessarily be applicable to this product.

NCBI GI #

4507937

NCBI GeneID

7507

NCBI Accession #

NP_000371

UniProt Primary Accession #

P23025

UniProt Secondary Accession #

Q5T1U9; Q6LCW7; Q6LD02

UniProt Related Accession #

P23025

GenBank Nucleotide #

NM_000380.3

NCBI Official Full Name

DNA repair protein complementing XP-A cells isoform 1

NCBI Official Synonym Full Names

XPA, DNA damage recognition and repair factor

NCBI Official Symbol

XPA

NCBI Official Synonym Symbols

XP1; XPAC

UniProt Protein Name

DNA repair protein complementing XP-A cells

UniProt Synonym Protein Names

Xeroderma pigmentosum group A-complementing protein

Protein Family

DNA repair protein

UniProt Gene Name

XPA

UniProt Synonym Gene Names

XPAC

NCBI Protein Information

DNA repair protein complementing XP-A cells

NCBI Summary for XPA

This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]

UniProt Comments for XPA

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.

Research Articles on XPA

1. Data suggest that the multi-protein interactions involved in the nucleotide excision repair (NER) process and potential cytotoxic mechanism associated with Ni(2+) binding in xeroderma pigmentosum complementation group A protein (XPA) may facilitate rational anti-cancer drug design based on the NER mechanism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with XPA recombinant protein

Reference Product	PubMed Publications
XPC recombinant protein	>301 publications with XPA and XPC
ERCC1 recombinant protein	>192 publications with XPA and ERCC1
ERCC2 recombinant protein	>97 publications with XPA and ERCC2
ERCC5 recombinant protein	>38 publications with XPA and ERCC5
PCNA recombinant protein	>36 publications with XPA and PCNA
ERCC4 recombinant protein	>33 publications with XPA and ERCC4
ERCC3 recombinant protein	>20 publications with XPA and ERCC3
RAD23B recombinant protein	>19 publications with XPA and RAD23B
RPA2 recombinant protein	>4 publications with XPA and RPA2
RAD23A recombinant protein	>3 publications with XPA and RAD23A

Pathways associated with XPA recombinant protein

Products by Pathway	Pathway Diagram
DNA Repair Pathway antibodies	DNA Repair Pathway Diagram
Dual Incision In GG-NER Pathway antibodies	Dual Incision In GG-NER Pathway Diagram
Dual Incision In TC-NER Pathway antibodies	Dual Incision In TC-NER Pathway Diagram
Formation Of Incision Complex In GG-NER Pathway antibodies	Formation Of Incision Complex In GG-NER Pathway Diagram
Formation Of TC-NER Pre-Incision Complex Pathway antibodies	Formation Of TC-NER Pre-Incision Complex Pathway Diagram
Global Genome Nucleotide Excision Repair (GG-NER) Pathway antibodies	Global Genome Nucleotide Excision Repair (GG-NER) Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram
Platinum Drug Resistance Pathway antibodies	Platinum Drug Resistance Pathway Diagram

Diseases associated with XPA recombinant protein

Disease Name	Pubmed Publications
Xeroderma Pigmentosum Antibodies	>810 publications with XPA and Xeroderma Pigmentosum
Precancerous Conditions Antibodies	>279 publications with XPA and Precancerous Conditions
Skin Neoplasms Antibodies	>81 publications with XPA and Skin Neoplasms
Death Antibodies	>68 publications with XPA and Death
Disease Models, Animal Antibodies	>62 publications with XPA and Disease Models, Animal
Lung Neoplasms Antibodies	>55 publications with XPA and Lung Neoplasms
Lung Diseases Antibodies	>46 publications with XPA and Lung Diseases
Neoplasms, Experimental Antibodies	>43 publications with XPA and Neoplasms, Experimental
Liver Neoplasms Antibodies	>26 publications with XPA and Liver Neoplasms
Intestinal Neoplasms Antibodies	>22 publications with XPA and Intestinal Neoplasms

Organs/Tissues associated with XPA recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>200 publications with XPA and Skin
Lung Antibodies	>94 publications with XPA and Lung
Blood Antibodies	>66 publications with XPA and Blood
Liver Antibodies	>65 publications with XPA and Liver
Brain Antibodies	>40 publications with XPA and Brain
Bone Antibodies	>22 publications with XPA and Bone
Kidney Antibodies	>19 publications with XPA and Kidney
Ganglia Antibodies	>14 publications with XPA and Ganglia
Eye Antibodies	>8 publications with XPA and Eye
Prostate Antibodies	>8 publications with XPA and Prostate