FCGR2B Recombinant Protein

Name: FCGR2B Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205028
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205028

FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

FCGR2B, Recombinant Protein

Full Product Name

FCGR2B, 46-217aa, Human, His tag, E Coli

Product Gene Name

FCGR2B recombinant protein

Product Synonym Names

Fc fragment of IgG low affinity IIb receptor; Fc fragment of IgG; low affinity IIb; receptor; CD32; CD32B; FCG2; FCGR2; IGFR2

Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAPPKA VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAP

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

22.0 kDa (197aa) confirmed by MALDI-TOF

OMIM

U87560 mRNA

3D Structure

ModBase 3D Structure for P31994

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for FCGR2B recombinant protein

Immunology

Applications Tested/Suitable for FCGR2B recombinant protein

SDS-PAGE

Product References and Citations for FCGR2B recombinant protein

Wang,L.H.,et al. (2012) Biochim. Biophys. Acta 1823 (2), 505-513; Baerenwaldt,A., et al. (2011) Proc. Natl. Acad. Sci. u.S.A. 108 (46), 18772-18777;

Other Notes

Small volumes of FCGR2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCGR2B purchase

MBS205028 is a recombinant protein targeting FCGR2B. Also known as FCGR2B, 46-217aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR2B. It may not necessarily be applicable to this product.

NCBI GI #

50511926

NCBI GeneID

2213

NCBI Accession #

NP_001002274

UniProt Primary Accession #

P31994

UniProt Secondary Accession #

O95649; Q53X85; Q5VXA9; Q8NIA1; A6H8N3

UniProt Related Accession #

P31994

GenBank Nucleotide #

NM_001002274.2

NCBI Official Full Name

low affinity immunoglobulin gamma Fc region receptor II-b isoform 3

NCBI Official Synonym Full Names

Fc fragment of IgG receptor IIb

NCBI Official Symbol

FCGR2B

NCBI Official Synonym Symbols

CD32; FCG2; CD32B; FCGR2; IGFR2

UniProt Protein Name

Low affinity immunoglobulin gamma Fc region receptor II-b

UniProt Synonym Protein Names

CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD_antigen: CD32

Protein Family

Low affinity immunoglobulin gamma Fc region receptor

UniProt Gene Name

FCGR2B

UniProt Synonym Gene Names

CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b

NCBI Protein Information

low affinity immunoglobulin gamma Fc region receptor II-b

NCBI Summary for FCGR2B

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

UniProt Comments for FCGR2B

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Research Articles on FCGR2B

1. This first genome-wide association approach for cyclophosphamide response in lupus nephritis patients yielded a robust profile of genetic associations including large-effect SNP in the FCGR2B-FCRLA locus, which may provide better insights to cyclophosphamide metabolism and efficacy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FCGR2B recombinant protein

Reference Product	PubMed Publications
INPP5D recombinant protein	>7 publications with FCGR2B and INPP5D
FCER1G recombinant protein	>2 publications with FCGR2B and FCER1G
FCER1A recombinant protein	>1 publications with FCGR2B and FCER1A
CD79B recombinant protein	>1 publications with FCGR2B and CD79B

Pathways associated with FCGR2B recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies	Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Measles Pathway antibodies	Measles Pathway Diagram

Diseases associated with FCGR2B recombinant protein

Disease Name	Pubmed Publications
Autoimmune Diseases Antibodies	>162 publications with FCGR2B and Autoimmune Diseases
Lupus Erythematosus, Systemic Antibodies	>79 publications with FCGR2B and Lupus Erythematosus, Systemic
Inflammation Antibodies	>64 publications with FCGR2B and Inflammation
Disease Models, Animal Antibodies	>63 publications with FCGR2B and Disease Models, Animal
Kidney Diseases Antibodies	>33 publications with FCGR2B and Kidney Diseases
Necrosis Antibodies	>30 publications with FCGR2B and Necrosis
Hemorrhage Antibodies	>15 publications with FCGR2B and Hemorrhage
Lung Diseases Antibodies	>15 publications with FCGR2B and Lung Diseases
Malaria Antibodies	>6 publications with FCGR2B and Malaria
Fibrosis Antibodies	>4 publications with FCGR2B and Fibrosis

Organs/Tissues associated with FCGR2B recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>238 publications with FCGR2B and Blood
Spleen Antibodies	>38 publications with FCGR2B and Spleen
Kidney Antibodies	>26 publications with FCGR2B and Kidney
Bone Marrow Antibodies	>26 publications with FCGR2B and Bone Marrow
Lymph Node Antibodies	>23 publications with FCGR2B and Lymph Node
Brain Antibodies	>17 publications with FCGR2B and Brain
Lung Antibodies	>13 publications with FCGR2B and Lung
Liver Antibodies	>8 publications with FCGR2B and Liver
Skin Antibodies	>4 publications with FCGR2B and Skin
Connective Tissue Antibodies	>3 publications with FCGR2B and Connective Tissue