AMN Recombinant Protein

Name: AMN Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205047
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205047

AMN, also known as amnionless, is a type I transmembrane protein. A complex of amnionless and cubilin forms the cubam receptor. This protein is necessary for efficient absorption of vitamin B12. It is thought to modulate bone morphogenetic protein (BMP)… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AMN, Recombinant Protein

Full Product Name

AMN, 20-357aa, Human, His tag, E Coli

Product Gene Name

AMN recombinant protein

Product Synonym Names

protein amnionless; PRO1028

Sequence

MGSSHHHHHH SSGLVPRGSH MGSVSKLWVP NTDFDVAANW SQNRTPCAGG AVEFPADKMV SVLVQEGHAV SDMLLPLDGE LVLASGAGFG VSDVGSHLDC GAGEPAVFRD SDRFSWHDPH LWRSGDEAPG LFFVDAERVP CRHDDVFFPP SASFRVGLGP GASPVRVRSI SALGRTFTRD EDLAVFLASR AGRLRFHGPG ALSVGPEDCA DPSGCVCGNA EAQPWICAAL LQPLGGRCPQ AACHSALRPQ GQCCDLCGAV VLLTHGPAFD LERYRARILD TFLGLPQYHG LQVAVSKVPR SSRLREADTE IQVVLVENGP ETGGAGRLAR ALLADVAENG EALGVLEATM RESGAHVWGS S

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

38.2 kDa (361aa), confirmed by MALDI-TOF

OMIM

AF328788 mRNA

3D Structure

ModBase 3D Structure for Q9BXJ7

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for AMN recombinant protein

Metabolism

Applications Tested/Suitable for AMN recombinant protein

SDS-PAGE

Product References and Citations for AMN recombinant protein

Fyfe J.C., et al. (2004) Blood 103:1573-1579; Tomihara-Newberger, C., et al. (1999) Dev. Biol. 204: 34-54.;

Other Notes

Small volumes of AMN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMN purchase

MBS205047 is a recombinant protein targeting AMN. Also known as AMN, 20-357aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AMN. It may not necessarily be applicable to this product.

NCBI GI #

110611172

NCBI GeneID

81693

NCBI Accession #

NP_112205

UniProt Primary Accession #

Q9BXJ7

UniProt Secondary Accession #

Q6UX83

UniProt Related Accession #

Q9BXJ7

GenBank Nucleotide #

NM_030943.3

NCBI Official Full Name

protein amnionless

NCBI Official Synonym Full Names

amnion associated transmembrane protein

NCBI Official Symbol

AMN

NCBI Official Synonym Symbols

PRO1028; amnionless

UniProt Protein Name

Protein amnionless

Protein Family

Amnesiac neuropeptides

UniProt Gene Name

AMN

NCBI Protein Information

protein amnionless

NCBI Summary for AMN

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

UniProt Comments for AMN

Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm ().

Research Articles on AMN

1. heterozygous mutations in AMN in a family from the United Kingdom with clinical features of Imerslund-Grasbeck Syndrome

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AMN recombinant protein

Reference Product	PubMed Publications
CUBN recombinant protein	>22 publications with AMN and CUBN
GIF recombinant protein	>6 publications with AMN and GIF
LRP2 recombinant protein	>4 publications with AMN and LRP2
BMP1 recombinant protein	>1 publications with AMN and BMP1
C1S recombinant protein	>1 publications with AMN and C1S
C1R recombinant protein	>1 publications with AMN and C1R

Pathways associated with AMN recombinant protein

Products by Pathway	Pathway Diagram
Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies	Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defects In Cobalamin (B12) Metabolism Pathway antibodies	Defects In Cobalamin (B12) Metabolism Pathway Diagram
Defects In Vitamin And Cofactor Metabolism Pathway antibodies	Defects In Vitamin And Cofactor Metabolism Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Of Metabolism Pathway antibodies	Diseases Of Metabolism Pathway Diagram
HDL-mediated Lipid Transport Pathway antibodies	HDL-mediated Lipid Transport Pathway Diagram
Lipid Digestion, Mobilization, And Transport Pathway antibodies	Lipid Digestion, Mobilization, And Transport Pathway Diagram
Lipoprotein Metabolism Pathway antibodies	Lipoprotein Metabolism Pathway Diagram

Diseases associated with AMN recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>224 publications with AMN and Nervous System Diseases
Intestinal Diseases Antibodies	>48 publications with AMN and Intestinal Diseases
Kidney Diseases Antibodies	>38 publications with AMN and Kidney Diseases
Proteinuria Antibodies	>32 publications with AMN and Proteinuria
Anemia Antibodies	>31 publications with AMN and Anemia
Necrosis Antibodies	>29 publications with AMN and Necrosis
MEGALOBLASTIC ANEMIA 1 Antibodies	>27 publications with AMN and MEGALOBLASTIC ANEMIA 1
Hypertrophy Antibodies	>25 publications with AMN and Hypertrophy
Inflammation Antibodies	>18 publications with AMN and Inflammation
Atrophy Antibodies	>18 publications with AMN and Atrophy

Organs/Tissues associated with AMN recombinant protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>223 publications with AMN and Heart
Muscle Antibodies	>100 publications with AMN and Muscle
Kidney Antibodies	>48 publications with AMN and Kidney
Intestine Antibodies	>23 publications with AMN and Intestine
Testis Antibodies	>11 publications with AMN and Testis
Lung Antibodies	>9 publications with AMN and Lung
Stomach Antibodies	>4 publications with AMN and Stomach
Lymph Node Antibodies	>3 publications with AMN and Lymph Node
Pancreas Antibodies	>3 publications with AMN and Pancreas