CFD Recombinant Protein

Name: CFD Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205072
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205072

CFD, also known as adipsin, is involved in the alternative complement pathway of the complement system where it cleaves factor B. This protein is a member of the trypsin family of peptidases. It is a component of the alternative complement pathway best known… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CFD, Recombinant Protein

Full Product Name

CFD, 26-253aa, Human, His tag, E Coli (Denatured)

Product Gene Name

CFD recombinant protein

Product Synonym Names

Complement factor D; DF; AND; PFD; ADIPSIN

Sequence

MGSSHHHHHH SSGLVPRGSH MILGGREAEA HARPYMASVQ LNGAHLCGGV LVAEQWVLSA AHCLEDAADG KVQVLLGAHS LSQPEPSKRL YDVLRAVPHP DSQPDTIDHD LLLLQLSEKA TLGPAVRPLP WQRVDRDVAP GTLCDVAGWG IVNHAGRRPD SLQHVLLPVL DRATCNRRTH HDGAITERLM CAESNRRDSC KGDSGGPLVC GGVLEGVVTS GSRVCGNRKK PGIYTRVASY AAWIDSVLA

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.4M urea

Purity/Purification

> 85% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

26.6 kDa (249aa)

OMIM

AJ313463 mRNA

3D Structure

ModBase 3D Structure for P00746

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for CFD recombinant protein

Immunology

Applications Tested/Suitable for CFD recombinant protein

SDS-PAGE

Application Notes for CFD recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for CFD recombinant protein

Narayana SV. et al. (1994) J Mol Biol. 235:695-708.; Ronti T. et al. (2006) Clin Endocrinol (Oxf). 64:355-365.;

Other Notes

Small volumes of CFD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CFD purchase

MBS205072 is a recombinant protein targeting CFD. Also known as CFD, 26-253aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CFD. It may not necessarily be applicable to this product.

NCBI GI #

42544239

NCBI GeneID

1675

NCBI Accession #

NP_001919

UniProt Primary Accession #

P00746

UniProt Secondary Accession #

Q5U5S1; Q86VJ5; Q8N4E0; Q8WZB4; B4DV76

UniProt Related Accession #

P00746

GenBank Nucleotide #

NM_001928.3

NCBI Official Full Name

complement factor D isoform 1 preproprotein

NCBI Official Synonym Full Names

complement factor D

NCBI Official Symbol

CFD

NCBI Official Synonym Symbols

DF; ADN; PFD; ADIPSIN

UniProt Protein Name

Complement factor D

UniProt Synonym Protein Names

Adipsin; C3 convertase activator; Properdin factor D

Protein Family

Complement factor

UniProt Gene Name

CFD

UniProt Synonym Gene Names

DF; PFD

NCBI Protein Information

complement factor D

NCBI Summary for CFD

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]

UniProt Comments for CFD

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Research Articles on CFD

1. disturbance of reciprocal relationships between adipsin and leptin in obesity is associated with the development of insulin resistance

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CFD recombinant protein

Reference Product	PubMed Publications
CFB recombinant protein	>10 publications with CFD and CFB
SERPING1 recombinant protein	>1 publications with CFD and SERPING1
SERPINE1 recombinant protein	>1 publications with CFD and SERPINE1

Pathways associated with CFD recombinant protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Alternative Complement Activation Pathway antibodies	Alternative Complement Activation Pathway Diagram
Complement Activation Pathway antibodies	Complement Activation Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram

Diseases associated with CFD recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>619 publications with CFD and Cardiovascular Diseases
Heart Diseases Antibodies	>184 publications with CFD and Heart Diseases
Heart Failure Antibodies	>69 publications with CFD and Heart Failure
Death Antibodies	>44 publications with CFD and Death
Hyperplasia Antibodies	>43 publications with CFD and Hyperplasia
Disease Models, Animal Antibodies	>33 publications with CFD and Disease Models, Animal
Inflammation Antibodies	>30 publications with CFD and Inflammation
Hypertension Antibodies	>25 publications with CFD and Hypertension
Carcinoma Antibodies	>23 publications with CFD and Carcinoma
Kidney Diseases Antibodies	>15 publications with CFD and Kidney Diseases

Organs/Tissues associated with CFD recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>998 publications with CFD and Blood
Vascular Antibodies	>687 publications with CFD and Vascular
Heart Antibodies	>403 publications with CFD and Heart
Lung Antibodies	>164 publications with CFD and Lung
Brain Antibodies	>110 publications with CFD and Brain
Bone Antibodies	>96 publications with CFD and Bone
Mouth Antibodies	>75 publications with CFD and Mouth
Liver Antibodies	>43 publications with CFD and Liver
Muscle Antibodies	>40 publications with CFD and Muscle
Eye Antibodies	>36 publications with CFD and Eye