VTCN1 Recombinant Protein

Name: VTCN1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205117
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205117

The VCTN1 is a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VTCN1, Recombinant Protein

Full Product Name

VTCN1, 25-259aa, Human, His tag, E Coli (Denatured)

Product Gene Name

VTCN1 recombinant protein

Product Synonym Names

V-set domain containing T cell activation inhibitor 1; B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291; RP11-229A19.4; VCTN1

Sequence

MGSSHHHHHH SSGLVPRGSH MGSLIIGFGI SGRHSITVTT VASAGNIGED GILSCTFEPD IKLSDIVIQW LKEGVLGLVH EFKEGKDELS EQDEMFRGRT AVFADQVIVG NASLRLKNVQ LTDAGTYKCY IITSKGKGNA NLEYKTGAFS MPEVNVDYNA SSETLRCEAP RWFPQPTVVW ASQVDQGANF SEVSNTSFEL NSENVTMKVV SVLYNVTINN TYSCMIENDI AKATGDIKVT ESEIKRRSHL QLLNSKAS

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1.0mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

28.2kDa (258aa)

OMIM

AY280972 mRNA

3D Structure

ModBase 3D Structure for Q7Z7D3

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for VTCN1 recombinant protein

Cancer

Applications Tested/Suitable for VTCN1 recombinant protein

SDS-PAGE

Application Notes for VTCN1 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for VTCN1 recombinant protein

Fauci,J.M., et al. (2012) Gynecol. Oncol. 127 (2), 420-425; Galazka,K., et al. (2012) Am. J. Reprod. Immunol. 68 (1), 85-93;

Other Notes

Small volumes of VTCN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VTCN1 purchase

MBS205117 is a recombinant protein targeting VTCN1. Also known as VTCN1, 25-259aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for VTCN1. It may not necessarily be applicable to this product.

NCBI GI #

99028881

NCBI GeneID

79679

NCBI Accession #

NP_078902

UniProt Primary Accession #

Q7Z7D3

UniProt Secondary Accession #

Q0GN76; Q45VN0; Q5WPZ3; Q6P097; Q9H6B2

UniProt Related Accession #

Q7Z7D3

GenBank Nucleotide #

NM_024626.3

NCBI Official Full Name

V-set domain-containing T-cell activation inhibitor 1 isoform 1

NCBI Official Synonym Full Names

V-set domain containing T cell activation inhibitor 1

NCBI Official Symbol

VTCN1

NCBI Official Synonym Symbols

B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291

UniProt Protein Name

V-set domain-containing T-cell activation inhibitor 1

UniProt Synonym Protein Names

B7 homolog 4; B7-H4; B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x

Protein Family

V-set domain containing T-cell activation inhibitor

UniProt Gene Name

VTCN1

UniProt Synonym Gene Names

B7-H4

NCBI Protein Information

V-set domain-containing T-cell activation inhibitor 1

NCBI Summary for VTCN1

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

UniProt Comments for VTCN1

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Research Articles on VTCN1

1. PD-L1, IDO-1, and B7-H4 are differentially expressed in human lung carcinomas and show limited co-expression. While PD-L1 and IDO-1 are associated with increased tumor-infiltrating lymphoycte and IFN-gamma stimulation, B7-H4 is not.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with VTCN1 recombinant protein

Reference Product	PubMed Publications
CD80 recombinant protein	>71 publications with VTCN1 and CD80
IL10 recombinant protein	>17 publications with VTCN1 and IL10
CTLA4 recombinant protein	>7 publications with VTCN1 and CTLA4
BTLA recombinant protein	>4 publications with VTCN1 and BTLA
CD86 recombinant protein	>3 publications with VTCN1 and CD86
IL6 recombinant protein	>3 publications with VTCN1 and IL6
PDCD1LG2 recombinant protein	>3 publications with VTCN1 and PDCD1LG2
ICOSLG recombinant protein	>2 publications with VTCN1 and ICOSLG

Pathways associated with VTCN1 recombinant protein

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with VTCN1 recombinant protein

Disease Name	Pubmed Publications
Genital Diseases, Female Antibodies	>29 publications with VTCN1 and Genital Diseases, Female
Ovarian Neoplasms Antibodies	>23 publications with VTCN1 and Ovarian Neoplasms
Breast Neoplasms Antibodies	>19 publications with VTCN1 and Breast Neoplasms
Neoplasm Metastasis Antibodies	>18 publications with VTCN1 and Neoplasm Metastasis
Inflammation Antibodies	>13 publications with VTCN1 and Inflammation
Lung Neoplasms Antibodies	>12 publications with VTCN1 and Lung Neoplasms
Neoplasms, Experimental Antibodies	>11 publications with VTCN1 and Neoplasms, Experimental
Liver Diseases Antibodies	>9 publications with VTCN1 and Liver Diseases
Cell Transformation, Neoplastic Antibodies	>8 publications with VTCN1 and Cell Transformation, Neoplastic
Kidney Diseases Antibodies	>7 publications with VTCN1 and Kidney Diseases

Organs/Tissues associated with VTCN1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>14 publications with VTCN1 and Lung
Pancreas Antibodies	>10 publications with VTCN1 and Pancreas
Liver Antibodies	>10 publications with VTCN1 and Liver
Kidney Antibodies	>8 publications with VTCN1 and Kidney
Bone Antibodies	>6 publications with VTCN1 and Bone
Uterus Antibodies	>5 publications with VTCN1 and Uterus
Prostate Antibodies	>3 publications with VTCN1 and Prostate
Ovary Antibodies	>3 publications with VTCN1 and Ovary
Bladder Antibodies	>1 publications with VTCN1 and Bladder
Cervix Antibodies	>1 publications with VTCN1 and Cervix